1913269-12-1
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- CAS号:
- 1913269-12-1
- 英文名:
- KN-93 (phosphate)
- 英文别名:
- KN93 Phosphate,KN 93 Phosphate
- 中文名:
- 1913269-12-1
- 中文别名:
- CBNumber:
- CB43155062
- 分子式:
- C26H32ClN2O8PS
- 分子量:
- 599.03
- MOL File:
- 1913269-12-1.mol
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1913269-12-1化学性质
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形态:
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Solid
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颜色:
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White to off-white
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1913269-12-1性质、用途与生产工艺
KN-93是钙离子/钙调蛋白依赖激酶II（CaMKII）抑制剂，能竞争性阻断钙调蛋白与对应激酶的结合，Ki为370 nM。
After 2 days of KN-93 treatment, 95% of cells are arrested in G1. G1 arrest is reversible; 1 day after KN-93 release, a peak of cells had progressed into S and G2-M. KN-93 also blocks cell growth stimulated by basic fibroblast growth factor, platelet-derived growth factor-BB, and epidermal growth factor in NIH 3T3 fibroblasts. KN-93 inhibits the H
+
, K
+
-ATPase activity but strongly dissipates the proton gradient formed in the gastric membrane vesicles and reduces the volume of luminal space. KN-93 (0.5 μM) prevents increased LV developed pressure during action potential prolongation and early afterdepolarizations. Ca
2+
-independent CaM kinase activity is increased during early afterdepolarizations and this increase is prevented by KN-93.
1913269-12-1
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1913269-12-1, 1913269-12-1 相关搜索:
- 抑制剂
- 1913269-12-1
- KN93 Phosphate,KN 93 Phosphate