TLR2-IN-C29
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- CAS号:
- 363600-92-4
- 英文名:
- TLR2-IN-C29
- 英文别名:
- R2-IN-C29;TLR2-IN-C29;C29;C 29;C-29;TLR2-IN-C29 (C29 );3-((2-Hydroxy-3-methoxybenzylidene)amino)-2-methylbenzoic acid;Benzoic acid, 3-[[(2-hydroxy-3-methoxyphenyl)methylene]amino]-2-methyl-;C29,TLR2,Inhibitor,hTLR2/1,inhibit,C-29,Toll-like,Toll-like Receptor (TLR),hTLR2/6,C 29
- 中文名:
- TLR2-IN-C29
- 中文别名:
- 化合物C29;3-((2-羟基-3-甲氧基亚苄基)氨基)-2-甲基苯甲酸
- CBNumber:
- CB43168697
- 分子式:
- C16H15NO4
- 分子量:
- 285.29
- MOL File:
- 363600-92-4.mol
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TLR2-IN-C29化学性质
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熔点:
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>192°C (dec.)
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沸点:
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505.7±50.0 °C(Predicted)
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密度:
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1.21±0.1 g/cm3(Predicted)
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储存条件:
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Inert atmosphere,Store in freezer, under -20°C
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溶解度:
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DMSO (Slightly), Methanol (Slightly)
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形态:
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Solid
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酸度系数(pKa):
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4.01±0.10(Predicted)
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颜色:
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Dark Orange
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稳定性:
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Moisture Sensitive
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TLR2-IN-C29性质、用途与生产工艺
TLR2-IN-C29 (C29)是一种 Toll-like receptor 2 (TLR2) 的抑制剂，可抑制TLR2/1和TLR2/6的信号传导。
C29 (10 or 50 μΜ; 1 hour) blocks P3C- and P2C-induced IL-8 mRNA dose-dependently in HEK-TLR2 stable transfectants. C29 (50-200 μM; 1 hour) inhibits P3C- and P2C-induced IL-1β gene expression significantly at both 1 h and 4 h following stimulation in THP-1 cells.
C29 (25 or 50 μΜ; 1 hour) reduces P3C-induced but not P2C-induced TNF-α mRNA and IL-12 p40 protein significantly in primary murine macrophages.
C29 (50 μΜ; 1 hour) blocks TLR2 bacterial agonist-induced proinflammatory gene expression in HEK-TLR2 cells and murine macrophages.
Western Blot Analysis
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Cell Line:
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THP-1 cells
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Concentration:
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150 μM
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Incubation Time:
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1 hours
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Result:
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Diminished the interaction between endogenous TLR2 and myeloid differentiation primary response gene 88 (MyD88) at 15 and 30 min poststimulation with P3C.
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Western Blot Analysis
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Cell Line:
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Murine peritoneal macrophages
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Concentration:
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50 μM
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Incubation Time:
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1 hours
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Result:
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Blocked robust MAPK activation at 30 min and reduced NF-κB activation from 5 to 30 min.
Prevented P3C-induced degradation of IκBα at 15 and 30 min.
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TLR2-IN-C29
上下游产品信息
上游原料
下游产品
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
|---|
| 2024/04/30 | S6597 | TLR2-IN-C29
TLR2-IN-C29 | 363600-92-4 | 5mg | 1170元 |
| 2024/04/30 | S6597 | TLR2-IN-C29 | 363600-92-4 | 10mM (1mL in DMSO) | 1285.83元 |
363600-92-4, TLR2-IN-C29 相关搜索:
- 药靶配体
- 化合物C29
- 3-((2-羟基-3-甲氧基亚苄基)氨基)-2-甲基苯甲酸
- 363600-92-4
- C29,TLR2,Inhibitor,hTLR2/1,inhibit,C-29,Toll-like,Toll-like Receptor (TLR),hTLR2/6,C 29
- C29;C 29;C-29
- R2-IN-C29
- Benzoic acid, 3-[[(2-hydroxy-3-methoxyphenyl)methylene]amino]-2-methyl-
- 3-((2-Hydroxy-3-methoxybenzylidene)amino)-2-methylbenzoic acid
- TLR2-IN-C29 (C29 )
- TLR2-IN-C29