DBCO-NHS ESTER 3
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- CAS号:
- 1393350-27-0
- 英文名:
- DBCO-(CH2)2-NH2-CO-(CH2)3COOH-NHS
- 英文别名:
- DBCO-NHS ester 3;DBCO-C5-NHS-ester;DBCO-NHS ester 3
(DIBAC-NHS);DBCO-(CH2)2-NH2-CO-(CH2)3COOH-NHS;2,5-Dioxo-1-pyrrolidinyl 11,12-didehydro-δ-oxodibenz[b,f]azocine-5(6H)-pentanoate;Dibenz[b,?f]azocine-5(6H)-pentanoic acid, 11,?12-didehydro-δ-oxo-, 2,5-dioxo-1-pyrrolidinyl ester;(2,5-Dioxopyrrolidin-1-yl) 5-(2-azatricyclo[10.4.0.04,9]hexadeca-1(16),4,6,8,12,14-hexaen-10-yn-2-yl)-5-oxopentanoate
- 中文名:
- DBCO-NHS ESTER 3
- 中文别名:
- 2,5-二氧代-1-吡咯烷基 11,12-二脱氢-Δ-氧代二苯并[B,F]氮杂辛烷-5(6H)-戊酸酯
- CBNumber:
- CB43358339
- 分子式:
- C24H20N2O5
- 分子量:
- 416.43
- MOL File:
- 1393350-27-0.mol
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DBCO-NHS ESTER 3化学性质
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沸点:
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679.2±65.0 °C(Predicted)
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密度:
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1.40±0.1 g/cm3(Predicted)
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酸度系数(pKa):
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-0.19±0.20(Predicted)
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InChI:
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InChI=1S/C24H20N2O5/c27-21(10-5-11-24(30)31-26-22(28)14-15-23(26)29)25-16-19-8-2-1-6-17(19)12-13-18-7-3-4-9-20(18)25/h1-4,6-9H,5,10-11,14-16H2
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InChIKey:
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CFQHVJJWCDJMLI-UHFFFAOYSA-N
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SMILES:
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C(N1CC2=CC=CC=C2C#CC2=CC=CC=C12)(=O)CCCC(=O)ON1C(CCC1=O)=O
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DBCO-NHS ESTER 3性质、用途与生产工艺
DBCO-NHS ester 3 (Compound 12) 是一种用于制备抗体偶联药物 (ADC) 的可降解 linker。DBCO-NHS ester 3 是一种二苯基环辛酮 (DBCO) 衍生物，通过 MeOND 和 DIBAC 的羧酸部分被 N-羟基琥珀酰亚胺活化而获得的。
DBCO-NHS ESTER 3
上下游产品信息
上游原料
下游产品
1393350-27-0, DBCO-NHS ESTER 3 相关搜索:
- ADC LINKER
- 2,5-二氧代-1-吡咯烷基 11,12-二脱氢-Δ-氧代二苯并[B,F]氮杂辛烷-5(6H)-戊酸酯
- 1393350-27-0
- 2,5-Dioxo-1-pyrrolidinyl 11,12-didehydro-δ-oxodibenz[b,f]azocine-5(6H)-pentanoate
- DBCO-C5-NHS-ester
- (2,5-Dioxopyrrolidin-1-yl) 5-(2-azatricyclo[10.4.0.04,9]hexadeca-1(16),4,6,8,12,14-hexaen-10-yn-2-yl)-5-oxopentanoate
- Dibenz[b,?f]azocine-5(6H)-pentanoic acid, 11,?12-didehydro-δ-oxo-, 2,5-dioxo-1-pyrrolidinyl ester
- DBCO-NHS ester 3
- DBCO-NHS ester 3
(DIBAC-NHS)
- DBCO-(CH2)2-NH2-CO-(CH2)3COOH-NHS