S 3304
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- CAS号:
- 203640-27-1
- 英文名:
- (R)-3-(1H-Indol-3-yl)-2-(5-(p-tolylethynyl)thiophene-2-sulfonamido)propanoic acid
- 英文别名:
- R-3-(1H-Indol-3-yl)-2-(5-(p-tolyleth ynyl)thiophene-2;S 3304,Inhibitor,inhibit,S3304,MMP,S-3304,Matrix metalloproteinases;D-Tryptophan, N-[[5-[2-(4-methylphenyl)ethynyl]-2-thienyl]sulfonyl]-;(R)-3-(1H-Indol-3-yl)-2-(5-(p-tolylethynyl)thiophene-2-sulfonamido)propanoic acid;(R)-3-(1H-Indol-3-yl)-2-(5-p-tolylethynyl-thiophene-2-sulfonylamino)-propionic acid;(2R)-3-(1H-indol-3-yl)-2-{5-[2-(4-methylphenyl)ethynyl]thiophene-2-sulfonamido}propanoic acid;(2R)-3-(1H-indol-3-yl)-2-[[5-[2-(4-methylphenyl)ethynyl]thiophen-2-yl]sulfonylamino]propanoic acid
- 中文名:
- S 3304
- 中文别名:
- 化合物S 3304;(R)-3-(1H-吲哚-3-基)-2-(5-(对甲苯基炔基)噻吩-2-亚磺酰氨基)丙酸
- CBNumber:
- CB43369157
- 分子式:
- C24H20N2O4S2
- 分子量:
- 464.56
- MOL File:
- 203640-27-1.mol
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S 3304化学性质
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沸点:
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745.7±70.0 °C(Predicted)
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密度:
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1.47±0.1 g/cm3(Predicted)
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储存条件:
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under inert gas (nitrogen or Argon) at 2–8 °C
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溶解度:
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Aqueous Base (Slightly), DMSO (Slightly)
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形态:
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Solid
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酸度系数(pKa):
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3.29±0.10(Predicted)
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颜色:
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Pale Beige to Light Beige
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S 3304性质、用途与生产工艺
S 3304 是一个新型的基质金属蛋白酶 (MMP) 抑制剂, 且对 MMP-2 和 MMP-9 有特异的抑制活性。
S 3304 is a novel D-tryptophan derivative and a potent, orally active, noncytotoxic Matrix metalloproteinases inhibitor (MMPI). Biochemical studies show that S 3304 most potently inhibits the activities of MMP-2 and MMP-9 but does not inhibit MMP-1, MMP-3, or MMP-7 and may, therefore, lack the musculoskeletal side effects seen with nonspecific inhibitors.
In vivo
pharmacologic studies have shown that the oral administration of S 3304, at a dose range of 20 to 200 mg/kg, inhibits angiogenesis, artificially induced in mice by the dorsal air-sac method. Similar oral doses of S 3304 result in potent inhibition of metastatic lung colonization of Lewis murine lung carcinoma injected via tail vein and liver metastasis of C-1H human colon cancer implanted into the spleen.
S 3304
上下游产品信息
上游原料
下游产品
203640-27-1, S 3304 相关搜索:
- 化合物S 3304
- (R)-3-(1H-吲哚-3-基)-2-(5-(对甲苯基炔基)噻吩-2-亚磺酰氨基)丙酸
- 203640-27-1
- S 3304,Inhibitor,inhibit,S3304,MMP,S-3304,Matrix metalloproteinases
- (R)-3-(1H-Indol-3-yl)-2-(5-p-tolylethynyl-thiophene-2-sulfonylamino)-propionic acid
- D-Tryptophan, N-[[5-[2-(4-methylphenyl)ethynyl]-2-thienyl]sulfonyl]-
- (2R)-3-(1H-indol-3-yl)-2-[[5-[2-(4-methylphenyl)ethynyl]thiophen-2-yl]sulfonylamino]propanoic acid
- (2R)-3-(1H-indol-3-yl)-2-{5-[2-(4-methylphenyl)ethynyl]thiophene-2-sulfonamido}propanoic acid
- R-3-(1H-Indol-3-yl)-2-(5-(p-tolyleth ynyl)thiophene-2
- (R)-3-(1H-Indol-3-yl)-2-(5-(p-tolylethynyl)thiophene-2-sulfonamido)propanoic acid