PD 404182
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- CAS号:
- 72596-74-8
- 英文名:
- PD 404182
- 英文别名:
- PD 404,182;3,4-dihydro-2H-pyrimido[1,2-c][1,3]benzothiazin-6-imine;3,4-Dihydro-2H,6H-pyrimido[1,2-c][1,3]benzothiazin-6-imine;2H,6H-Pyrimido[1,2-c][1,3]benzothiazin-6-imine, 3,4-dihydro-;3,4-Dihydro-2H,6H-benzo[e]pyrimido[1,2-c][1,3]thiazin-6-imine;6H-6-IMINO-(2,3,4,5-TETRAHYDROPYRIMIDO)[1,2-C]-[1,3]BENZOTHIAZINE
- 中文名:
- PD 404182
- 中文别名:
- 化合物 T28348;PD404182|||PD-404182
- CBNumber:
- CB4347334
- 分子式:
- C11H11N3S
- 分子量:
- 217.29
- MOL File:
- Mol file
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PD 404182化学性质
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沸点:
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366.8±25.0 °C(Predicted)
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密度:
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1.43±0.1 g/cm3(Predicted)
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储存条件:
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2-8°C
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溶解度:
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DMSO: ≥22 mg/mL, soluble
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酸度系数(pKa):
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6.27±0.20(Predicted)
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形态:
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powder
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颜色:
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Light yellow to yellow
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PD 404182性质、用途与生产工艺
PD 404182 是一种有效的、竞争性的人类二甲基精氨酸二甲基氨基水解酶 1 (DDAH1) 抑制剂,IC50 值为 9 μM。PD 404182 在体外表现出抗血管生成和抗病毒活性。
PD 404182 (20 μM) increases asymmetric dimethylarginine (ADMA) approximately 70% in ECs.
PD 404182 (50-100 μM; 18 hours) attenuates endothelial tube formation in virto and does not perturb cell membrane integrity or induces cytotoxicity.
PD 404182 inhibits HIV-1 in seminal plasma, with an IC
50
of 1 μM.
PD 404182 (300 μM;30 minutes) exhibits low toxicity toward several human cell lines , freshly activated PBMCs, primary CD
4+
T lymphocytes, macrophages, and dendritic cells, and lactobacilli found in the normal vaginal flora.
Cell Viability Assay
Cell Line:
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Human dermal microvascular endothelial cells (ECs)
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Concentration:
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10-300 μM
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Incubation Time:
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24 hours
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Result:
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Did not induce cytotoxicity.
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PD 404182
上下游产品信息
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下游产品
更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
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2024/04/30 | HY-16958 | PD 404182 PD 404182 | 72596-74-8 | 5mg | 1850元 |
2024/04/30 | HY-16958 | PD 404182 | | 10 mM * 1 mLin DMSO | 2035元 |
72596-74-8, PD 404182 相关搜索:
- PD404182|||PD-404182
- 化合物 T28348
- 72596-74-8
- 2H,6H-Pyrimido[1,2-c][1,3]benzothiazin-6-imine, 3,4-dihydro-
- 3,4-dihydro-2H-pyrimido[1,2-c][1,3]benzothiazin-6-imine
- 3,4-Dihydro-2H,6H-pyrimido[1,2-c][1,3]benzothiazin-6-imine
- 3,4-Dihydro-2H,6H-benzo[e]pyrimido[1,2-c][1,3]thiazin-6-imine
- PD 404,182
- 6H-6-IMINO-(2,3,4,5-TETRAHYDROPYRIMIDO)[1,2-C]-[1,3]BENZOTHIAZINE