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EB-3D

生物活性 靶点 体外研究 体内研究 EB-3D 试剂级价格
EB-3D, 1839150-63-8, 结构式
EB-3D
CAS号:
1839150-63-8
英文名:
EB-3D
英文别名:
EB-3D;ChoK inhibitor EB-3D;1,1'-(((Ethane-1,2-diylbis(oxy))bis(4,1-phenylene))bis(methylene))bis(4-(dimethylamino)pyridin-1-ium) bromide;1,1'-(((Ethane-1,2-diylbis(oxy))bis(4,1-phenylene))bis(methylene))bis(4-(dimethylamino)pyridin-1-ium) bromide;lipid,inhibit,lymphoblastic,AMP-activated protein kinase,EB3D,acute,tumorigenesis,Apoptosis,homeostasis,dephosphorylation,AMPK,Inhibitor,EB 3D,leukemia,EB-3D,HepG2
中文名:
EB-3D
中文别名:
化合物EB-3D;1,1'-(((乙烷-1,2-二基双(氧基))双(4,1-亚苯基))双(亚甲基))双(4-(二甲氨基)吡啶-1-鎓)溴化物;1,1'-(((乙烷-1,2-二基双(氧基))双(4,1-亚苯基))双(亚甲基))双(4-(二甲氨基)吡啶-1-鎓)溴化物
CBNumber:
CB44667867
分子式:
C30H36BrN4O2+
分子量:
564.55
MOL File:
1839150-63-8.mol

EB-3D化学性质

储存条件:
Inert atmosphere,Room Temperature
溶解度:
DMSO: 50 mg/mL (77.59 mM)
形态:
Solid
颜色:
White to off-white
安全信息

EB-3D性质、用途与生产工艺

生物活性

EB-3D 是一种有效的 choline kinase α (ChoKα) 的选择性抑制剂，对ChoKα1的IC50值为1 μM。EB-3D 可在白血病T细胞中诱导 AMPK-mTOR 通路失调和凋亡。

靶点

TargetValue
ChoKα1
(Cell-free assay) 		1 μM

体外研究

EB-3D displays (0-100 μM; 72 hours) excellent antiproliferative activity against a wide cohort of T-leukemic cell lines, with GI GI 50 s 13 values in the nanomolar range.
EB-3D (1.25-5μM; 24 hours) induced apoptosis in leukemia cell lines.
EB-3D (0.5-1 μM; 24 hours) induces a G0/G1 arrest that lead to apoptosis.
EB-3D (0.3 μM; 48 hours) shows a first spike of activation of AMPKα after 30 minutes and a later increase in the phosphorylation of T172.
EB-3D (1-40 μM; 48 hours) inhibits cell growth in HepG2 cells with a GI 50 of 14.55 μM.
EB-3D induces deregulation of the AMPK-mTOR pathway and apoptosis in leukemia T-cells.

Cell Proliferation Assay

Cell Line: JURKAT, CCRF-CEM, HSB-2, MOLT-16, DNA-41, LOUCY, PEER, ALL-SIL cells
Concentration: 0.001, 0.01, 0.1, 1, 10, 100 μM
Incubation Time: 72 hours
Result: Inhibited JURKAT, CCRF-CEM, HSB-2, MOLT-16, DNA-41, LOUCY, PEER, and ALL-SIL cells growth with GI 50 s of 136.2, 478.8, 17.7, 0.9, 60.6, 200, 265, and 132 nM, respectively.

Apoptosis Analysis

Cell Line: Jurkat, CCRF-CEM and HSB-2 cells
Concentration: 1.25, 2.5, 5 μM
Incubation Time: 24 hours
Result: Induced apoptosis in leukemia cell lines.

Cell Cycle Analysis

Cell Line: Jurkat, CCRF-CEM and HSB-2 cells
Concentration: 0.5, 1 μM
Incubation Time: 24 hours
Result: Induces cell cycle arrest in G0/G1 phase.

Western Blot Analysis

Cell Line: Jurkat cells
Concentration: 0.3 μM
Incubation Time: 48 hours
Result: Showed a first spike of activation of AMPKα after 30 minutes of treatment and a later increase in the phosphorylation of T172. The increase in S79 phosphorylation of its main target ACC (acetyl-coenzyme A (CoA) carboxylase), followed the same pattern. This rapid activation of AMPK, in turn induced a consequent reduction in mTOR phosphorylation that is visible already at 30’ and that becomes amplified at longer time probably due to the interruption of feedback loops that are characteristic of mTOR connecting pathways.

体内研究

EB-3D (1 mg/kg; i.p.; every other day) impairs mammary tumor growth in syngeneic orthotopic E0771-C57BL/6 mouse model.
EB-3D (2.5 mg/kg; every other day for 4 weeks) shows a reduction of the number of spontaneous lung macro- and micrometastasis.

Animal Model: E0771-C57BL/6 mice
Dosage: I.p.; every other day for 4 weeks
Administration: 2.5 mg/kg
Result: A reduction of the number of spontaneous lung macro- and micrometastasis.

EB-3D 上下游产品信息

上游原料

下游产品

EB-3D 试剂级价格

更新日期产品编号产品名称CAS编号包装价格
2024/04/30HY-115463EB-3D1 mg952元
2024/04/30HY-115463EB-3D
EB-3D		1839150-63-85mg1900元

EB-3D 生产厂家

全球有 25家供应商   EB-3D国内生产厂家
供应商联系电话电子邮件国家产品数优势度
上海一飞生物科技有限公司 021-65675885 18964387627 info@efebio.com 中国 9707 58
上海源叶生物科技有限公司 021-61312847; 18021002903 3008007409@qq.com 中国 27322 60
上海超岚化工科技中心 QQ:65489617 15618227136 info@SuperLan-chem.com 中国 9887 58
北京普西唐生物科技有限公司 010-60605840 18892239720 psaitong@jm-bio.com 中国 12308 58
上海禹犇生物科技有限公司 15502154572 yuben012@sina.com 中国 507 58
HANGZHOU CLAP TECHNOLOGY CO.,LTD 86-571-88216897,88216896 13588875226 sales@hzclap.com 中国 6313 58
河南威梯希化工科技有限公司 0371-63284658 18135795563 2885349392@qq.com 中国 10003 58
郑州安慕斯化工产品有限公司 0371-55289822 18737195735 483339295@qq.com 中国 7099 58
成都超九八生物科技有限公司 13348960310 13348960310 3003867561@qq.com 中国 10011 58
天津普西唐生物医药科技有限公司 010-60605840 15801484223 psaitong@jm-bio.com 中国 29778 58
上海毕得医药科技股份有限公司 400-1647117 15221909166 product02@bidepharm.com 中国 63720 58
TargetMol中国（陶术生物） 4008200310 marketing@tsbiochem.com 中国 24017 58
上海一研生物科技有限公司 021-69985186 13611928337 3427709316@qq.com 中国 7984 58
北京索莱宝科技有限公司 010-50973130 17801761073 Gsiyu@solarbio.com 中国 50751 58
上海瀚鸿科技股份有限公司 021-54306202 18917919676 info@hanhongsci.com 中国 29990 58
上海陌孚医药科技有限公司 021-59167510 18117107507 vip@med-life.cn 中国 5014 58
南京世洲生物科技有限公司 025-85560043 15850508050 cindy.huang@synzest.com 中国 12007 58
上海阿拉丁生化科技股份有限公司 +86-18521732826 market@aladdin-e.com 中国 48467 58
銳迪國際科技有限公司 18024082417 market@ubiochem.com 中国 9282 58
ATK CHEMICAL COMPANY LIMITED +undefined-21-51877795 ivan@atkchemical.com 中国 32760 60
Aladdin Scientific +1-+1(833)-552-7181 sales@aladdinsci.com 美国 57511 58
TargetMol Chemicals Inc. +1-781-999-5354 support@targetmol.com 美国 19973 58
 

1839150-63-8, EB-3D 相关搜索:

  • 药靶配体
  • 抑制剂
  • 1,1'-(((乙烷-1,2-二基双(氧基))双(4,1-亚苯基))双(亚甲基))双(4-(二甲氨基)吡啶-1-鎓)溴化物
  • 化合物EB-3D
  • 1,1'-(((乙烷-1,2-二基双(氧基))双(4,1-亚苯基))双(亚甲基))双(4-(二甲氨基)吡啶-1-鎓)溴化物
  • 1839150-63-8
  • 1,1'-(((Ethane-1,2-diylbis(oxy))bis(4,1-phenylene))bis(methylene))bis(4-(dimethylamino)pyridin-1-ium) bromide
  • lipid,inhibit,lymphoblastic,AMP-activated protein kinase,EB3D,acute,tumorigenesis,Apoptosis,homeostasis,dephosphorylation,AMPK,Inhibitor,EB 3D,leukemia,EB-3D,HepG2
  • 1,1'-(((Ethane-1,2-diylbis(oxy))bis(4,1-phenylene))bis(methylene))bis(4-(dimethylamino)pyridin-1-ium) bromide
  • ChoK inhibitor EB-3D
  • EB-3D
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