ALX 40-4C Trifluoroacetate
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- CAS号:
- 英文名:
- ALX 40-4C Trifluoroacetate
- 英文别名:
- ALX 40-4C Trifluoroacetate
- 中文名:
- ALX 40-4C Trifluoroacetate
- 中文别名:
- CBNumber:
- CB44713636
- 分子式:
- C??H???F?N??O??
- 分子量:
- 0
- MOL File:
- Mol file
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ALX 40-4C Trifluoroacetate化学性质
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形态:
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Solid
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颜色:
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White to off-white
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ALX 40-4C Trifluoroacetate性质、用途与生产工艺
ALX 40-4C Trifluoroacetate 是一种趋化因子受体 (CXCR4) 抑制剂,能够抑制 SDF-1 与 CXCR4 结合,Ki 值为 1 μM,具有抗 HIV-1 作用;ALX 40-4C Trifluoroacetate 同时为 APJ 受体拮抗剂,IC50 值为 2.9 μM。
SDF-1-CXCR4
1 μM (Ki)
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APJ receptor
2.9 μM (IC
50
)
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ALX 40-4C Trifluoroacetate is a small peptide inhibitor of the chemokine receptor CXCR4, interacts with the second extracellular loop of CXCR4 and inhibits infection exclusively by blocking direct virus-CXCR4 interactions. ALX 40-4C shows potent anti HIV-1 effect, with EC
50
s of 0.34 ± 0.04 μg/mL, 0.37 ± 0.01 μg/mL for HIV-1 NL4-3, NC10, and 0.18 ± 0.11 μg/mL, 0.06 ± 0.02 μg/mL for HIV-1 HXB2, HC43, respectively, and with a CC
50
(50% cytotoxic concentration) of 21 μg/mL. ALX 40-4C also exhibits potent activity against env-recombinant HIV, with EC
50
s of 0.38 ± 0.01 μg/mL, 0.40 ± 0.0 μg/mL for HIV-1 NL4-3 env, NC10, and 1.34 ± 0.06 μg/mL, 1.02 ± 0.29 μg/mL for HIV-1 HXB2 env, HC43, and a CC
50
of 21 μg/mL. ALX 40-4C binds to APJ with an IC
50
of 2.9 μM. ALX 40-4C inhibits HIV-1 gp120/APJ-mediated cell membrane fusion, with an IC
50
s of 3.41 μM and 3.1 μM for IIIB isolate and 89.6 isolate, respectively.
ALX 40-4C Trifluoroacetate
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ALX 40-4C Trifluoroacetate 试剂级价格
更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
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2024/08/19 | HY-P7061A | ALX 40-4C Trifluoroacetate ALX 40-4C Trifluoroacetate | | 1mg | 2400元 |
2024/08/19 | HY-P7061A | ALX 40-4C Trifluoroacetate ALX 40-4C Trifluoroacetate | | 5mg | 8500元 |
ALX 40-4C Trifluoroacetate
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