DMU2139
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- CAS号:
- 1821143-80-9
- 英文名:
- DMU2139
- 英文别名:
- CYP1B1 inhibitor;DMU2139(CYP1B1 inhibitor 6j);DMU2139;DMU-2139;DMU 2139;CYP1B1 INHIBITOR;1821143-80-9;(E)-1-(6-methoxynaphthalen-2-yl)-3-pyridin-3-ylprop-2-en-1-one;2-Propen-1-one, 1-(6-methoxy-2-naphthalenyl)-3-(3-pyridinyl)-, (2E)-
- 中文名:
- DMU2139
- 中文别名:
- 化合物 T11066;(E)-1-(6-甲氧基萘-2-基)-3-(吡啶-3-基)丙-2-烯-1-酮
- CBNumber:
- CB44796646
- 分子式:
- C19H15NO2
- 分子量:
- 289.33
- MOL File:
- 1821143-80-9.mol
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DMU2139化学性质
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沸点:
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488.6±45.0 °C(Predicted)
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密度:
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1.199±0.06 g/cm3(Predicted)
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储存条件:
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under inert gas (nitrogen or Argon) at 2-8°C
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溶解度:
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DMSO:77.5(Max Conc. mg/mL);267.86(Max Conc. mM)
Ethanol:5.0(Max Conc. mg/mL);17.28(Max Conc. mM)-
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酸度系数(pKa):
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3.80±0.11(Predicted)
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形态:
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Solid
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颜色:
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Light yellow to yellow
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DMU2139性质、用途与生产工艺
DMU2139 是有效的特异性细胞色素 P4501B1 (CYP1B1) 的抑制剂，其对 CYP1B1 和 CYP1A1 的 IC50 值分别为 9 nM，795 nM。
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CYP1B1
9 nM (IC
50
)
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CYP1A1
795 nM (IC
50
)
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DMU2139 (6j) shows 88 and 133-fold selectivity for CYP1B1 over CYP1A1 and CYP1A2. In the presence of DMU2139, the EC
50
is reversed back to 8.3 μM from 61 μM (seen in CYP1B1-expressing cells without any inhibitor). The EC
50
value, in the presence of DMU2139, resembles the EC
50
of cisplatin, 8.7μM, in cells transfected with the empty plasmid which has no CYP1B1 gene and therefore cannot express CYP1B1 protein.
DMU2139
上下游产品信息
上游原料
下游产品
1821143-80-9, DMU2139 相关搜索:
- API
- 化合物 T11066
- (E)-1-(6-甲氧基萘-2-基)-3-(吡啶-3-基)丙-2-烯-1-酮
- 1821143-80-9
- 2-Propen-1-one, 1-(6-methoxy-2-naphthalenyl)-3-(3-pyridinyl)-, (2E)-
- DMU2139;DMU-2139;DMU 2139;CYP1B1 INHIBITOR;1821143-80-9
- CYP1B1 inhibitor
- DMU2139(CYP1B1 inhibitor 6j)
- (E)-1-(6-methoxynaphthalen-2-yl)-3-pyridin-3-ylprop-2-en-1-one