RU320521
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- CAS号:
- 2262452-06-0
- 英文名:
- RU.521
- 英文别名:
- RU32052;RU320521;10mM in DMSO;RU.521 RU320521;RU320521 RU-320521;RU.521;RU521;RU-320521;1(3H)-Isobenzofuranone, 3-[1-(6,7-dichloro-1H-benzimidazol-2-yl)-5-hydroxy-3-methyl-1H-pyrazol-4-yl]-;3-(1-(6,7-dichloro-1H-benzo[d]imidazol-2-yl)-5-hydroxy-3-methyl-1H-pyrazol-4-yl)isobenzofuran-1(3H)-one;inflammatory,oxidative stress,RU 320521,cGAS,RU-320521,Inhibitor,inhibit,RU.521,Cyclic GMP-AMP Synthase,signaling pathway
- 中文名:
- RU320521
- 中文别名:
- RU-521游离态;化合物RU320521;3-(1-(6,7-二氯-1H-苯并[D]咪唑-2-基)-5-羟基-3-甲基-1H-吡唑-4-基)异苯并呋喃-1(3H) - 酮
- CBNumber:
- CB44869399
- 分子式:
- C19H12Cl2N4O3
- 分子量:
- 415.23
- MOL File:
- 2262452-06-0.mol
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RU320521化学性质
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沸点:
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658.2±65.0 °C(Predicted)
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密度:
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1.73±0.1 g/cm3(Predicted)
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储存条件:
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Keep in dark place,Sealed in dry,Store in freezer, under -20°C
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溶解度:
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Soluble in DMSO (>25 mg/ml)
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形态:
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solid
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酸度系数(pKa):
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6.17±0.30(Predicted)
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颜色:
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Off-white to pale pink
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稳定性:
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Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 2 months.
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InChI:
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InChI=1S/C19H12Cl2N4O3/c1-8-13(16-9-4-2-3-5-10(9)18(27)28-16)17(26)25(24-8)19-22-12-7-6-11(20)14(21)15(12)23-19/h2-7,16,26H,1H3,(H,22,23)
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InChIKey:
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VIQXILLOJLATEF-UHFFFAOYSA-N
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SMILES:
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C1(=O)C2=C(C=CC=C2)C(C2=C(O)N(C3NC4=C(Cl)C(Cl)=CC=C4N=3)N=C2C)O1
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RU320521性质、用途与生产工艺
RU.521 (RU320521)是一种活跃的 cyclic GMP-AMP synthase (cGAS) 的有效的选择性抑制剂,可抑制cGAS介导的信号传导,其IC50值为700 nM。RU.521 与cGAS/dsDNA 复合物结合的Kd值为36.2 nM。
Target | Value |
cGAS/dsDNA complex
(Cell-free assay)
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36.2 nM(Kd)
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cGAS
(Cell-free assay)
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700 nM
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RU320521
上下游产品信息
上游原料
下游产品
更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
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2024/08/19 | S6841 | RU320521 RU.521 | 2262452-06-0 | 5mg | 1290.13元 |
2024/08/19 | S6841 | RU.521 | 2262452-06-0 | 10mM (1mL in DMSO) | 1570元 |
2262452-06-0, RU320521 相关搜索:
- 药靶配体
- RU-521游离态
- 化合物RU320521
- 3-(1-(6,7-二氯-1H-苯并[D]咪唑-2-基)-5-羟基-3-甲基-1H-吡唑-4-基)异苯并呋喃-1(3H) - 酮
- 2262452-06-0
- 10mM in DMSO
- RU32052
- RU320521 RU-320521
- inflammatory,oxidative stress,RU 320521,cGAS,RU-320521,Inhibitor,inhibit,RU.521,Cyclic GMP-AMP Synthase,signaling pathway
- RU.521 RU320521
- 3-(1-(6,7-dichloro-1H-benzo[d]imidazol-2-yl)-5-hydroxy-3-methyl-1H-pyrazol-4-yl)isobenzofuran-1(3H)-one
- 1(3H)-Isobenzofuranone, 3-[1-(6,7-dichloro-1H-benzimidazol-2-yl)-5-hydroxy-3-methyl-1H-pyrazol-4-yl]-
- RU320521
- RU.521;RU521;RU-320521