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2-[(Cyclopropylsulfonyl)amino]-N-(2-ethoxyphenyl)benzamide
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- CAS号:
- 1646499-97-9
- 英文名:
- 2-[(Cyclopropylsulfonyl)amino]-N-(2-ethoxyphenyl)benzamide
- 英文别名:
- ML 382;2-cyclopropanesulfonamido-N-(2-ethoxyphenyl)benzamide;2-[(Cyclopropylsulfonyl)amino]-N-(2-ethoxyphenyl)benzamide;Benzamide, 2-[(cyclopropylsulfonyl)amino]-N-(2-ethoxyphenyl)-;ML382,Inhibitor,ML 382,nociceptor,pain,injury,DRG,inhibit,neurons,nervous,ML-382
- 中文名:
- 2-[(Cyclopropylsulfonyl)amino]-N-(2-ethoxyphenyl)benzamide
- 中文别名:
- 化合物ML382;2-(环丙烷磺酰胺基)-N-(2-乙氧基苯基)苯甲酰胺
- CBNumber:
- CB44902689
- 分子式:
- C18H20N2O4S
- 分子量:
- 360.43
- MOL File:
- 1646499-97-9.mol
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2-[(Cyclopropylsulfonyl)amino]-N-(2-ethoxyphenyl)benzamide化学性质
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密度:
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1.34±0.1 g/cm3(Predicted)
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储存条件:
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Store at -20°C
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溶解度:
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Soluble in DMSO
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形态:
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A solid
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酸度系数(pKa):
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8.30±0.20(Predicted)
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颜色:
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White to off-white
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2-[(Cyclopropylsulfonyl)amino]-N-(2-ethoxyphenyl)benzamide性质、用途与生产工艺
ML382 是一种有效选择性的 Mas 相关 G 蛋白偶联受体 X1 MRGPRX1 (MrgX1) 正向调节剂，EC50 为 190 nM。
In the absence of ML382, the IC
50
for BAM8-22 inhibition of
I
Ca
is 0.66 ± 0.05 μM. In the presence of 0.1 μM, 1 μM, 10 μM, and 30 μM ML382, BAM8-22 IC
50
is reduced to 0.43 ± 0.02 μM, 0.25 ± 0.02 μM, 0.06 ± 0.01 μM, and 0.08 ± 0.01 μM, respectively. A lower IC
50
generally indicates a higher potency; thus, ML382 dose-dependently increases the potency of BAM8–22, further demonstrating that ML382 is a positive allosteric modulator of MRGPRX1.
ML382 (5 μM) significantly increases inhibition of
I
Ca
by a low concentration of BAM8–22 (0.5 μM) in DRG neurons from
MrgprX1
mice. ML382 enhances the inhibition of spinal synaptic transmission by BAM8-22 in
MrgprX1
mice. ML382 (25 μM, 125 μM, and 250 μM; 5 μL; i.th.;) dose-dependently attenuates heat hypersensitivity in
MrgprX1
mice. ML382 (lumbar puncture injection; 25 μM, 5 μL) leads to a significant increase in postconditioning time spent in the ML382-paired chamber, compared with the preconditioning value. ML382 inhibits nerve injury-induced ongoing pain in
MrgprX1
mice.
2-[(Cyclopropylsulfonyl)amino]-N-(2-ethoxyphenyl)benzamide
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下游产品
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
|---|
| 2024/08/19 | HY-110285 | ML382 | | 1 mg | 348元 |
| 2024/08/19 | HY-110285 | ML382 | | 5 mg | 870元 |
2-[(Cyclopropylsulfonyl)amino]-N-(2-ethoxyphenyl)benzamide
生产厂家
1646499-97-9, 2-[(Cyclopropylsulfonyl)amino]-N-(2-ethoxyphenyl)benzamide 相关搜索:
- 抑制剂
- 化合物ML382
- 2-(环丙烷磺酰胺基)-N-(2-乙氧基苯基)苯甲酰胺
- 1646499-97-9
- 2-cyclopropanesulfonamido-N-(2-ethoxyphenyl)benzamide
- ML382,Inhibitor,ML 382,nociceptor,pain,injury,DRG,inhibit,neurons,nervous,ML-382
- Benzamide, 2-[(cyclopropylsulfonyl)amino]-N-(2-ethoxyphenyl)-
- ML 382
- 2-[(Cyclopropylsulfonyl)amino]-N-(2-ethoxyphenyl)benzamide