CKI-7
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- CAS号:
- 120615-25-0
- 英文名:
- CKI-7
- 英文别名:
- CKI-7 free base;CKI 7 free base,CKI7 free base;N-(2-Aminoethyl)-5-chloro-8-isoquinolinesulfonamide;N-(2-AMinoethyl)-5-chloro-isoquinolin-8-sulphonaMide;8-Isoquinolinesulfonamide, N-(2-aminoethyl)-5-chloro-;8-[N-(2-Aminoethyl)sulphamoyl]-5-chloroisoquinoline, CKI-7;8-Isoquinolinesulfonamide, N-(2-aminoethyl)-5-chloro- Dihydrochloride
- 中文名:
- CKI-7
- 中文别名:
- 化合物 T10829
- CBNumber:
- CB4503226
- 分子式:
- C11H12ClN3O2S
- 分子量:
- 285.75
- MOL File:
- 120615-25-0.mol
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CKI-7化学性质
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熔点:
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188-190°C
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沸点:
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499.7±55.0 °C(Predicted)
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密度:
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1.432±0.06 g/cm3(Predicted)
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储存条件:
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−20°C
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溶解度:
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H2O: 9 mg/mL
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形态:
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solid
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酸度系数(pKa):
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7.80±0.50(Predicted)
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颜色:
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white
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CKI-7性质、用途与生产工艺
CKI-7 free base 是一种有效且 ATP 竞争性的酪蛋白激酶 1 (CK1) 抑制剂，IC50 为 6 μM，Ki 为 8.5 μM。CKI-7 free base 选择性抑制 Cdc7 激酶，还抑制 SGK，S6K1 以及 MSK1。CKI-7 free base 对酪蛋白激酶 II 和其他蛋白激酶的作用弱得多。
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CK1
6 μM (IC
50
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CK1
8.5 μM (Ki)
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Cdc7
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SGK
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S6K1
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MSK1
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CKI-7 (0.1-10 μM; 5 days; ES cells) treatment significantly increases the expression of the early neuroectodermal marker Sox1 and the number of cells positive for the neural markers nestin and βIII-tubulin, in a concentration-dependent manner.
CKI-7 (5 μM; 5 days; ES cells) treatment suppresses SFEB-induced β-catenin stabilization on day 5, indicating that CKI-7 inhibits Wnt signaling.
RT-PCR
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Cell Line:
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Mouse ES cells
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Concentration:
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0.1-10 μM
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Incubation Time:
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5 days
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Result:
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Significantly increased the expression of the early neuroectodermal marker Sox1 and the number of cells positive for the neural markers nestin and βIII-tubulin, in a concentration-dependent manner.
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Western Blot Analysis
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Cell Line:
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Mouse ES cells
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Concentration:
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5 μM
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Incubation Time:
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5 days
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Result:
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Suppressed SFEB-induced β-catenin stabilization on day 5.
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In vivo dose-dependent anti-tumor activity of CKI-7 is demonstrated in a SCID-Beige mouse systemic tumor model utilzing a recently isolated Philadelphia chromosome positive acute lymphoblastic leukemia cell line. Standard cell cycle synchronization studies established that exposure to CKI-7 results in cell cycle dependent caspase 3 activation and apoptotic cell death.
CKI-7
上下游产品信息
上游原料
下游产品
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
|---|
| 2024/04/30 | HY-133028 | CKI-7
CKI-7 free base | 120615-25-0 | 5mg | 850元 |
| 2024/04/30 | HY-133028 | CKI-7
CKI-7 free base | 120615-25-0 | 10mg | 1500元 |
CKI-7
生产厂家
全球有 27家供应商
CKI-7国内生产厂家
120615-25-0, CKI-7 相关搜索:
- All Inhibitors
- Protein Kinase Inhibitors and Activators
- Inhibitors
- C11H12ClN3O2S2HCl
- 化合物 T10829
- 120615-25-0
- CKI 7 free base,CKI7 free base
- 8-Isoquinolinesulfonamide, N-(2-aminoethyl)-5-chloro-
- CKI-7 free base
- N-(2-Aminoethyl)-5-chloro-8-isoquinolinesulfonamide
- N-(2-AMinoethyl)-5-chloro-isoquinolin-8-sulphonaMide
- 8-[N-(2-Aminoethyl)sulphamoyl]-5-chloroisoquinoline, CKI-7
- 8-Isoquinolinesulfonamide, N-(2-aminoethyl)-5-chloro- Dihydrochloride