L-半胱亚磺酸
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- CAS号:
- 207121-48-0
- 英文名:
- L-CYSTEINESULFINIC ACID MONOHYDRATE
- 英文别名:
- 3-sulfino-l-alanine;Sulfino-L-alanine hydrate;L-Cysteinesulfinic Acid (hydrate);(2R)-2-aMino-3-sulfinopropanoic acid;L-Cysteinesulfinic acid Monohydrate 99%;(1R)-1-amino-2-mercaptoethanesulfinic acid hydrate;L Cysteinesulfinic acid monohydrate,LCysteinesulfinic acid monohydrate,Metabotropic glutamate receptors,Inhibitor,L-Cysteinesulfinic acid,inhibit,mGluR
- 中文名:
- L-半胱亚磺酸
- 中文别名:
- L-半胱亚磺酸水合物;L-半胱氨酸亚磺酸一水;L-半胱亚磺酸 一水合物;L-半胱氨酸亚磺酸一水合物
- CBNumber:
- CB4503615
- 分子式:
- HO2SCH2CH(NH2)CO2HH2O
- 分子量:
- 171.17
- MOL File:
- 207121-48-0.mol
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L-半胱亚磺酸化学性质
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熔点:
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163 °C (dec.)(lit.)
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储存条件:
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-20°C
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溶解度:
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Aqueous Acid (Slightly), Methanol (Slightly), Water (Slightly)
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形态:
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Solid
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颜色:
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White to Off-White
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旋光性 (optical activity):
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[α]25/D +24°, c = 1 in 1 M HCl
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稳定性:
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Temperature Sensitive
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L-半胱亚磺酸性质、用途与生产工艺
L-Cysteinesulfinic acid monohydrate 是一种有效的代谢型谷氨酸受体 (mGluRs) 激动剂，作用于 mGluR1，mGluR5，mGluR2，mGluR4，mGluR6 和 mGluR8，pEC50 分别为 3.92，4.6，3.9，2.7，4.0，和 3.94。
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mGluR1
3.92 (pEC
50
)
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mGluR2
3.9 (pEC
50
)
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mGluR4
2.7 (pEC
50
)
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mGluR5
4.6 (pEC
50
)
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mGluR6
4.0 (pEC
50
)
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mGluR8
3.94 (pEC
50
)
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L-Cysteinesulfinic acid is an endogenous agonist of a metabotropic receptor coupled to stimulation of phospholipase D (PLD) activity. L-CSA is an endogenous agonist of the PLD-coupled metabotropic excitatory amino acids (EAA) receptor. L-CSA selectively activates the PLD-coupled receptor. 1 mM L-CSA induces a significant increase in PLD activity in hippocampal slices, whereas 1 mM concentrations of L-glutamate, L-aspartate, and L-HCA are without effect. L-CSA elicits a dose-dependent increase in PLD activity in rat hippocampal slices in the presence of iGluR antagonists, with an approximate EC
50
of 500 uM. The PLD response induced by 1 mM L-CSA is not significantly decreased in the presence of 1 uM tetrodotoxin, suggesting that this response is not dependent upon L-CSA-induced increases in cell firing.
L-半胱亚磺酸
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207121-48-0, L-半胱亚磺酸 相关搜索:
- Sulfur & Selenium Compounds
- Amino Acids & Derivatives
- HO2SCH2CHNH2CO2HH2O
- L-半胱亚磺酸水合物
- L-半胱氨酸亚磺酸一水合物
- L-半胱氨酸亚磺酸一水
- L-半胱亚磺酸 一水合物
- 207121-48-0
- L Cysteinesulfinic acid monohydrate,LCysteinesulfinic acid monohydrate,Metabotropic glutamate receptors,Inhibitor,L-Cysteinesulfinic acid,inhibit,mGluR
- Sulfino-L-alanine hydrate
- L-Cysteinesulfinic Acid (hydrate)
- (1R)-1-amino-2-mercaptoethanesulfinic acid hydrate
- 3-sulfino-l-alanine
- L-Cysteinesulfinic acid Monohydrate 99%
- (2R)-2-aMino-3-sulfinopropanoic acid