AZ7550 Mesylate
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- CAS号:
- 2319837-99-3
- 英文名:
- AZ7550 Mesylate
- 英文别名:
- AZ7550 Mesylate;AZ7550 trimesylate salt
- 中文名:
- AZ7550 Mesylate
- 中文别名:
- AZ7550甲磺酸盐
- CBNumber:
- CB45419681
- 分子式:
- C28H35N7O5S
- 分子量:
- 581.69
- MOL File:
- 2319837-99-3.mol
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AZ7550 Mesylate化学性质
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形态:
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Solid
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颜色:
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Light yellow to yellow
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AZ7550 Mesylate性质、用途与生产工艺
AZ7550 Mesylate 是 AZD9291 的一种活性代谢物，AZ7550 抑制 IGF1R 活性，IC50 为 1.6 μM。
IC50: 1.6 μM (IGF1R), 88 nM (MLK1), 156 nM (ACK1), 195 nM (ErbB4), 228 nM (MNK2), 302 nM (FLT3), 420 nM (ALK ), 449 nM (FES), 840 nM (IRR), 843 nM (BRK), 977 nM (BLK), 995 nM (FAK), 1256 nM (Ins R), 1317 nM (TEC), 1784 nM (FLT4), 2288 nM (PYK2), 2443 nM (Txk), 5104 nM (BTK)
AZ7550 (Compound 28) appeares to offer a broadly similar potency and selectivity profile to the parent compound AZD9291. AZ7550 inhibits double mutant (DM) cell line H1975, activating mutant (AM) cell line PC9, and wild type (WT) cell line LoVo with IC
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s of 45, 26, and 786 nM, respectively. AZ7550 inhibits DM antiproliferative cell line H1975, AM antiproliferative cell line PC9, and WT antiproliferative cell line Calu3 with GI
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s of 19, 15, and 537 nM, respectively.
AZ7550 Mesylate
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| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
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| 2024/04/30 | HY-B0794B | AZ7550 Mesylate
AZ7550 Mesylate | 2319837-99-3 | 5mg | 2800元 |
| 2024/04/30 | HY-B0794B | AZ7550 Mesylate
AZ7550 Mesylate | 2319837-99-3 | 10mM * 1mLin DMSO | 3750元 |
2319837-99-3, AZ7550 Mesylate 相关搜索:
- AZ7550甲磺酸盐
- 2319837-99-3
- AZ7550 trimesylate salt
- AZ7550 Mesylate