Calcitonin Gene Related Peptide (CGRP) (83-119), rat
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- CAS号:
- 英文名:
- Calcitonin Gene Related Peptide (CGRP) (83-119), rat
- 英文别名:
- Calcitonin Gene Related Peptide (CGRP) (83-119), rat
- 中文名:
- 中文别名:
- CBNumber:
- CB45419696
- 分子式:
- C???H???N??O??S?
- 分子量:
- 0
- MOL File:
- Mol file
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Calcitonin Gene Related Peptide (CGRP) (83-119), rat化学性质
Calcitonin Gene Related Peptide (CGRP) (83-119), rat性质、用途与生产工艺
Calcitonin Gene Related Peptide (CGRP) (83-119), rat 是一种由 37 个氨基酸组成的降钙素家族神经肽,通过 (CRLR) 起作用。
Calcitonin Gene Related Peptide (CGRP) (83-119), rat belongs to the calcitonin family of neuropeptides which also includes adrenomedullin, amylin, calcitonin, intermedin and calcitonin receptor-stimulating peptide. Calcitonin Gene Related Peptide (CGRP) has two isoforms (αCGRP and βCGRP), and acts through calcitonin receptor-like receptor (CRLR). Calcitonin Gene Related Peptide (CGRP) plays a key role in migraine pathophysiology and is associated with activation of the trigeminovascular system. CGRP prossibly acts postjunctionally in these areas putatively involved in primary headaches.
CGRP is a potent inducer of oedema in rat orofacial tissue. CGRP (100 μL; 8-33 pmol) induces a rapidly developing (5-15 min) and long-lasting (6 h), dose-dependent oedema in the rat cheek. CGRP induces a smaller oedematogenic effect in the rat hind paw also blocked by the CGRP antagonist. CGRP (16 pmol) potentiates the oedema induced by co-injected substance P (3.7 nmol).
Calcitonin Gene Related Peptide (CGRP) (83-119), rat
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Calcitonin Gene Related Peptide (CGRP) (83-119), rat
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