STING AGONIST-4
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- CAS号:
- 2138300-40-8
- 英文名:
- 1H-Benzimidazole-5-carboxamide, 1,1'-(1,4-butanediyl)bis[2-[[(1-ethyl-3-methyl-1H-pyrazol-5-yl)carbonyl]amino]-
- 英文别名:
- STING agonist-4;diABZI STING Agonist-2;1,1'-(1,4-butanediyl)bis[2-[[(1-ethyl-3-methyl-1H-pyrazol-5-yl)carbonyl]amino]-1H-benzimidazole-5-carboxamide;1H-Benzimidazole-5-carboxamide, 1,1'-(1,4-butanediyl)bis[2-[[(1-ethyl-3-methyl-1H-pyrazol-5-yl)carbonyl]amino]-;1H-Benzimidazole-5-carboxamide, 1,1′-(1,4-butanediyl)bis[2-[[(1-ethyl-3-methyl-1H-pyrazol-5-yl)carbonyl]amino]- (ACI);TMEM173,STING agonist-4,MPYS,Inhibitor,STING agonist 4,STING,Stimulator of Interferon Genes,inhibit,ERIS,STING agonist4,MITA;1-{4-[5-carbamoyl-2-(1-ethyl-3-methyl-1H-pyrazole-5-amido)-1H-1,3-benzodiazol-1-yl]butyl}-2-(1-ethyl-3-methyl-1H-pyrazole-5-amido)-1H-1,3-benzodiazole-5-carboxamide
- 中文名:
- STING AGONIST-4
- 中文别名:
- 化合物STING AGONIST-4
- CBNumber:
- CB45479775
- 分子式:
- C34H38N12O4
- 分子量:
- 678.74
- MOL File:
- 2138300-40-8.mol
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STING AGONIST-4化学性质
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密度:
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1.48±0.1 g/cm3(Predicted)
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储存条件:
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Store at -20°C
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溶解度:
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DMSO: slightly soluble
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形态:
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A solid
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酸度系数(pKa):
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11.97±0.43(Predicted)
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颜色:
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White to gray
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STING AGONIST-4性质、用途与生产工艺
STING agonist-4 是干扰素基因 (STING) 的受体激动剂的刺激剂，它的表观抑制常数 IC50 为 20 nM，STING agonist-4 是一种含两个对称相关的氨基苯并咪唑 (ABZI) 基的化合物。
IC50: 20 nM (STING agonist-4)
STING agonist-4 (Compound 2) (0.3-30 μM; 2 hours) causes phosphorylation of IRF3 and STING that is inhibited by the TBK1 inhibitor BX795 and induces dose-dependent secretion of IFN-β with an EC
50
of 3.1 μM.
STING agonist-4 (Compound 2) (0.001 nM-1 μM) inhibits binding of full-length STING to the solid support with an apparent dissociation constant (K
d
) of approximately 1.6 nM.
STING agonist-4 (Compound 2) (0-100 μM) is 18-fold more potent than cGAMP (an endogenous STING ligand), with an EC
50
of 53.9 μM.
STING agonist-4 (Compound 2) (3 μM; 4 hours) promotes production of interferon γ-induced protein 10 (IP-10), IL-6 and TNF-α by a mechanism that is dependent on STING-mediated activation of TBK1.
Cell Viability Assay
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Cell Line:
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Human peripheral blood mononuclear cells (PBMCs)
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Concentration:
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0.3 μM, 1 μM, 3 μM, 10 μM and 30 μM
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Incubation Time:
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2 hours
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Result:
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Caused phosphorylation of IRF3 and STING and induced secretion of IFN-β.
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STING AGONIST-4
上下游产品信息
上游原料
下游产品
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
|---|
| 2024/11/08 | HY-123943 | STING agonist-4 | | 1 mg | 1600元 |
| 2024/11/08 | HY-123943 | STING AGONIST-4
STING agonist-4 | 2138300-40-8 | 5mg | 3500元 |
2138300-40-8, STING AGONIST-4 相关搜索:
- 普通化学品
- 活性分子
- C34H38N12O4
- 213830-40-8
- 化合物STING AGONIST-4
- 2138300-40-8
- 1-{4-[5-carbamoyl-2-(1-ethyl-3-methyl-1H-pyrazole-5-amido)-1H-1,3-benzodiazol-1-yl]butyl}-2-(1-ethyl-3-methyl-1H-pyrazole-5-amido)-1H-1,3-benzodiazole-5-carboxamide
- 1,1'-(1,4-butanediyl)bis[2-[[(1-ethyl-3-methyl-1H-pyrazol-5-yl)carbonyl]amino]-1H-benzimidazole-5-carboxamide
- 1H-Benzimidazole-5-carboxamide, 1,1′-(1,4-butanediyl)bis[2-[[(1-ethyl-3-methyl-1H-pyrazol-5-yl)carbonyl]amino]- (ACI)
- diABZI STING Agonist-2
- TMEM173,STING agonist-4,MPYS,Inhibitor,STING agonist 4,STING,Stimulator of Interferon Genes,inhibit,ERIS,STING agonist4,MITA
- STING agonist-4
- 1H-Benzimidazole-5-carboxamide, 1,1'-(1,4-butanediyl)bis[2-[[(1-ethyl-3-methyl-1H-pyrazol-5-yl)carbonyl]amino]-