CPUY074020
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- CAS号:
- 902279-44-1
- 英文名:
- CPUY074020
- 英文别名:
- CPUY074020;CPUY074020,CPUY-074020;3-(1-Piperidyl)-5-[[2-(1-pyrrolidinyl)ethyl]amino]-6H-anthra[1,9-cd]isoxazol-6-one;6H-Anthra[1,9-cd]isoxazol-6-one, 3-(1-piperidinyl)-5-[[2-(1-pyrrolidinyl)ethyl]amino]-
- 中文名:
- CPUY074020
- 中文别名:
- 化合物 T10882;化合物CPUY074020;3-(1-哌啶基)-5-[[2-(1-吡咯烷基)乙基]氨基]-6H-蒽并[1,9-CD]异噁唑-6-酮
- CBNumber:
- CB45821316
- 分子式:
- C25H28N4O2
- 分子量:
- 416.52
- MOL File:
- 902279-44-1.mol
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CPUY074020化学性质
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沸点:
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677.6±55.0 °C(Predicted)
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密度:
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1.305±0.06 g/cm3(Predicted)
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储存条件:
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Store at -20°C
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溶解度:
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Soluble in DMSO
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酸度系数(pKa):
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9.90±0.20(Predicted)
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CPUY074020性质、用途与生产工艺
CPUY074020 是一种高效、有口服活性的组蛋白甲基转移酶 G9a 抑制剂，其 IC50 值为 2.18 μM。CPUY074020 具有抗增殖活性。
CPUY074020 (2-8μM; 24 hours) induces cell death through apoptosis.
CPUY074020 (2.5-10μM ; 48 hours) dose-dependently de-regulates H3K9 trimethylation.
Apoptosis Analysis
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Cell Line:
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MCF-7 cells
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Concentration:
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2 μM, 4 μM, 8 μM
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Incubation Time:
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24 hours
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Result:
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Induced MCF-7 cells apoptosis.
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Western Blot Analysis
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Cell Line:
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MCF-7 cells
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Concentration:
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2.5 μM, 5 μM, 10 μM
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Incubation Time:
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48 hours
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Result:
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Dose-dependently de-regulated H3K9 trimethylation.
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CPUY074020 exhibits reasonable PK properties, with an oral bioavailability of 55.5% and a T
1/2
value of 4.0 hours at an oral dose of 10 mg/kg.
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Animal Model:
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Mice
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Dosage:
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10 mg/kg
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Administration:
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Oral administration
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Result:
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t
1/2
=4.0 hours
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CPUY074020
上下游产品信息
上游原料
下游产品
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
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| 2024/08/19 | HY-100757 | CPUY074020 | | 1 mg | 2205元 |
902279-44-1, CPUY074020 相关搜索:
- 抑制剂
- 对照品
- 化合物CPUY074020
- 化合物 T10882
- 3-(1-哌啶基)-5-[[2-(1-吡咯烷基)乙基]氨基]-6H-蒽并[1,9-CD]异噁唑-6-酮
- 902279-44-1
- CPUY074020,CPUY-074020
- 6H-Anthra[1,9-cd]isoxazol-6-one, 3-(1-piperidinyl)-5-[[2-(1-pyrrolidinyl)ethyl]amino]-
- 3-(1-Piperidyl)-5-[[2-(1-pyrrolidinyl)ethyl]amino]-6H-anthra[1,9-cd]isoxazol-6-one
- CPUY074020