网站主页 >> CAS数据库列表 >> AC-VAL-LEU-GLY-LYS-LEU-SER-GLN-GLU-LEU-HIS-LYS-LEU-GLN-THR-TYR-PRO-ARG-THR-ASN-THR-GLY-SER-ASN-THR-TYR-NH2
AC-VAL-LEU-GLY-LYS-LEU-SER-GLN-GLU-LEU-HIS-LYS-LEU-GLN-THR-TYR-PRO-ARG-THR-ASN-THR-GLY-SER-ASN-THR-TYR-NH2
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- CAS号:
- 151804-77-2
- 英文名:
- AC187
- 英文别名:
- AC187;AC187, amylin receptor antagonist;ACETYL-[ASN30 TYR32]-CALCITONIN FRAGMENT;AC-(ASN30,TYR32)-CALCITONIN (8-32) (SALMON I);Acetyl-(Asn??,Tyr??)-Calcitonin (8-32) (salmon I);ACETYL-(ASN30,TYR32)-CALCITONIN (8-32) (SALMON I);Acetyl-(Asn30,Tyr32)-Calcitonin (8-32) (salMon I)
AC187;8-32-Calcitonin (salmon reduced), N-acetyl-30-L-asparagine-32-L-tyrosinamide-;AC-VAL-LEU-GLY-LYS-LEU-SER-GLN-GLU-LEU-HIS-LYS-LEU-GLN-THR-TYR-PRO-ARG-THR-ASN-THR-GLY-SER-ASN-THR-TYR-NH2;ACETYL-VAL-LEU-GLY-LYS-LEU-SER-GLN-GLU-LEU-HIS-LYS-LEU-GLN-THR-TYR-PRO-ARG-THR-ASN-THR-GLY-SER-ASN-THR-TYR-NH2
- 中文名:
- AC-VAL-LEU-GLY-LYS-LEU-SER-GLN-GLU-LEU-HIS-LYS-LEU-GLN-THR-TYR-PRO-ARG-THR-ASN-THR-GLY-SER-ASN-THR-TYR-NH2
- 中文别名:
- 选择性拮抗剂多肽;AC187,胰岛淀粉样多肽受体拮抗剂;AC187,AMYLIN RECEPTOR拮抗剂
- CBNumber:
- CB4752202
- 分子式:
- C127H205N37O40
- 分子量:
- 2890.26
- MOL File:
- 151804-77-2.mol
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AC-VAL-LEU-GLY-LYS-LEU-SER-GLN-GLU-LEU-HIS-LYS-LEU-GLN-THR-TYR-PRO-ARG-THR-ASN-THR-GLY-SER-ASN-THR-TYR-NH2化学性质
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密度:
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1.49±0.1 g/cm3(Predicted)
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储存条件:
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-15°C
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溶解度:
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Soluble to 1 mg/ml in H2O
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形态:
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powder
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颜色:
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white to off-white
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水溶解性:
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Soluble to 1 mg/ml in water
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AC-VAL-LEU-GLY-LYS-LEU-SER-GLN-GLU-LEU-HIS-LYS-LEU-GLN-THR-TYR-PRO-ARG-THR-ASN-THR-GLY-SER-ASN-THR-TYR-NH2性质、用途与生产工艺
AC 187是一种具有口服活性的，高效的胰淀素受体 (amylin receptor) 拮抗剂 (IC50= 0.48 nM)，其选择性分别是降钙素受体和 CGRP 受体的 38 倍和 400 倍。在体外，AC 187 通过减弱启动子和效应子半胱天冬酶的激活，以阻断 β 淀粉样蛋白诱导的神经毒性。AC 187 增加胰高血糖素分泌，加速胃排空，改变血浆葡萄糖水平和增加食物摄入。
IC50: 0.48 nM (amylin receptor)
AC-VAL-LEU-GLY-LYS-LEU-SER-GLN-GLU-LEU-HIS-LYS-LEU-GLN-THR-TYR-PRO-ARG-THR-ASN-THR-GLY-SER-ASN-THR-TYR-NH2
上下游产品信息
上游原料
下游产品
AC-VAL-LEU-GLY-LYS-LEU-SER-GLN-GLU-LEU-HIS-LYS-LEU-GLN-THR-TYR-PRO-ARG-THR-ASN-THR-GLY-SER-ASN-THR-TYR-NH2
生产厂家
151804-77-2, AC-VAL-LEU-GLY-LYS-LEU-SER-GLN-GLU-LEU-HIS-LYS-LEU-GLN-THR-TYR-PRO-ARG-THR-ASN-THR-GLY-SER-ASN-THR-TYR-NH2 相关搜索:
- 药靶配体
- 多肽
- 目录肽
- 目录多肽
- C127H205N37O40
- AC187,AMYLIN RECEPTOR拮抗剂
- AC187,胰岛淀粉样多肽受体拮抗剂
- 选择性拮抗剂多肽
- 151804-77-2
- AC187, amylin receptor antagonist
- Acetyl-(Asn??,Tyr??)-Calcitonin (8-32) (salmon I)
- Acetyl-(Asn30,Tyr32)-Calcitonin (8-32) (salmon I) trifluoroacetate salt Ac-Val-Leu-Gly-Lys-Leu-Ser-Gln-Glu-Leu-His-Lys-Leu-Gln-Thr-Tyr-Pro-Arg-Thr-Asn-Thr-Gly-Ser-Asn-Thr-Tyr-NH2 trifluoroacetate salt
- 8-32-Calcitonin (salmon reduced), N-acetyl-30-L-asparagine-32-L-tyrosinamide-
- AC187
- AC-(ASN30,TYR32)-CALCITONIN (8-32) (SALMON I)
- ACETYL-VAL-LEU-GLY-LYS-LEU-SER-GLN-GLU-LEU-HIS-LYS-LEU-GLN-THR-TYR-PRO-ARG-THR-ASN-THR-GLY-SER-ASN-THR-TYR-NH2
- ACETYL-(ASN30,TYR32)-CALCITONIN (8-32) (SALMON I)
- Acetyl-(Asn30,Tyr32)-Calcitonin (8-32) (salMon I)
AC187
- AC-VAL-LEU-GLY-LYS-LEU-SER-GLN-GLU-LEU-HIS-LYS-LEU-GLN-THR-TYR-PRO-ARG-THR-ASN-THR-GLY-SER-ASN-THR-TYR-NH2
- ACETYL-[ASN30 TYR32]-CALCITONIN FRAGMENT