5-(十四烷基氧)-2-糠酸
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- CAS号:
- 54857-86-2
- 英文名:
- 5-(TETRADECYLOXY)-2-FUROIC ACID
- 英文别名:
- TOFA;mdl14514;RMI-14514;TOFA (RMI14514;RMI14514; MDL14514;TOFA (RMI14514:MDL14514);5-tetradecyloxy-2-furonicacid;5-(TETRADECYLOXY)-2-FUROIC ACID;5-(TETRADECYLOXY)-2-FUROIC TOFA;TOFA - CAS 54857-86-2 - Calbiochem
- 中文名:
- 5-(十四烷基氧)-2-糠酸
- 中文别名:
- 化合物TOFA;5-(十四烷氧基)-2-糠酸;5-(十四烷基氧)-2-糠酸;5-(十四氧基)呋喃-2-甲酸;5-四巯基呋喃-2-羧酸(TOFA);乙酰辅酶A羧化酶-Α(ACCA)变构抑制剂(TOFA)
- CBNumber:
- CB4759746
- 分子式:
- C19H32O4
- 分子量:
- 324.45
- MOL File:
- 54857-86-2.mol
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5-(十四烷基氧)-2-糠酸化学性质
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熔点:
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112-115 °C
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沸点:
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441.7±25.0 °C(Predicted)
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密度:
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1.003±0.06 g/cm3(Predicted)
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储存条件:
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-20°C
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溶解度:
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DMSO: 2.5 mg/mL
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形态:
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solid
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酸度系数(pKa):
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3.55±0.10(Predicted)
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颜色:
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white to beige
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稳定性:
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Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 1 month.
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5-(十四烷基氧)-2-糠酸性质、用途与生产工艺
5-(十四烷基氧)-2-糠酸可作为有机合成中间体和医药中间体,可用于实验室研发过程和化工医药生产过程中。
TOFA (5-(Tetradecyloxy)-2-furoic acid, Tyrphostin 46,Tyrphostin A46,Tyrphostin B40)是acetyl-CoA carboxylase-α (ACCA)的变构抑制剂。在细胞内TOFA转化为TOFyl-CoA (5-tetradecyloxy-2-furoyl-CoA),对ACCA具有变构抑制作用。 TOFA阻止脂肪酸合成,并以剂量依赖性方式诱导细胞死亡。
TOFA (5-tetradecyloxy-2-furoic acid) is cytotoxic to lung cancer cells NCI-H460 and colon carcinoma cells HCT-8 and HCT-15, with an IC
50
at approximately 5.0, 5.0, and 4.5 μg/mL, respectively. TOFA at 1.0–20.0 μg/mL effectively blocks fatty acid synthesis and induces cell death in a dose-dependent manner. TOFA is found to be cytotoxic to COC1 and COC1/DDP cells with IC
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values of ~26.1 and 11.6 µg/mL, respectively. TOFA inhibits the proliferation of the cancer cells examined in a time and dose dependent manner, arrests the cells in the G0/G1 cell cycle phase and induces apoptosis. Acetyl-CoA-carboxylase-α (ACCA) is a key enzyme in the regulation of fatty acids synthesis. Inhibition of ACCA by TOFA decreases fatty acid synthesis and induces caspase activation and cell death in most PCa cell lines.
TOFA inhibits COC1/DDP cell growth in ovarian tumor mouse xenografts. The tumor growth rate is signifi¬cantly inhibited by TOFA compared with the DMSO treated control mice (1649±356.3 vs. 5128±390.4 mm
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. No toxicity is observed in the heart, liver, spleen, lung, kidney and intestinal tissues. By inhibiting ACC, TOFA may be a promising small molecule agent for ovarian cancer therapy.
5-(十四烷基氧)-2-糠酸
上下游产品信息
上游原料
下游产品
更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
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2024/08/19 | HY-101068 | TOFA | | 1 mg | 250元 |
2024/08/19 | HY-101068 | 5-(十四烷基氧)-2-糠酸 TOFA | 54857-86-2 | 5mg | 500元 |
54857-86-2, 5-(十四烷基氧)-2-糠酸 相关搜索:
- 合成有机化合物配体
- 对照品
- 其它
- 细胞生物学试剂
- Acetyl CoA-Carboxylase
- Enzymes, Inhibitors, and Substrates
- Enzyme Inhibitors by Enzyme
- Enzyme Inhibitors
- BioChemical
- Biochemicals and Reagents
- A to C
- 5-四巯基呋喃-2-羧酸(TOFA)
- 5-(十四氧基)呋喃-2-甲酸
- 化合物TOFA
- 乙酰辅酶A羧化酶-Α(ACCA)变构抑制剂(TOFA)
- 5-(十四烷氧基)-2-糠酸
- 5-(十四烷基氧)-2-糠酸
- 54857-86-2
- inhibit,RMI 14514,Acetyl-CoA Carboxylase,ACC, Acetyl Coenzyme A Carboxylase,RMI-14514,TOFA,MDL 14514,MDL-14514,Inhibitor
- RMI14514; MDL14514
- TOFA - CAS 54857-86-2 - Calbiochem
- 5-(TETRADECYLOXY)-2-FUROIC TOFA
- TOFA (RMI14514:MDL14514)
- TOFA (RMI14514
- 2-Furancarboxylic acid,5-(tetradecyloxy)-
- 5-(TETRADECYLOXY)-2-FUROIC ACID
- 5-(TETRADECYLOXY)-2-FURANCARBOXYLIC ACID
- TOFA (5-(Tetradecyloxy)-2-furoic acid)
- RMI-14514
- mdl14514
- 5-tetradecyloxy-2-furonicacid
- 5-(tetradecyloxy)-2-furancarboxylicaci
- TOFA