6-MITC; 6 MITC; 6MITC
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- CAS号:
- 4430-35-7
- 英文名:
- 1-ISOTHIOCYANATO-6-(METHYLSULFINYL)-HEXANE
- 英文别名:
- 6-MITC;6-HITC;6-MITC; 6 MITC; 6MITC;6-METHYLSULFINYLHEXYL ISOTHIOCYANATE;1-ISOTHIOCYANATO-6-(METHYLSULFINYL)-HEXANE;Hexane, 1-isothiocyanato-6-(methylsulfinyl)-
- 中文名:
- 6-MITC; 6 MITC; 6MITC
- 中文别名:
- 化合物 T15474;化合物 HESPERIN;1-异硫氰基-6-(甲基亚磺酰基)-己烷
- CBNumber:
- CB4774237
- 分子式:
- C8H15NOS2
- 分子量:
- 205.34
- MOL File:
- Mol file
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6-MITC; 6 MITC; 6MITC化学性质
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沸点:
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385.9±25.0 °C(Predicted)
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密度:
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1.12±0.1 g/cm3(Predicted)
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储存条件:
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Refrigerator, under inert atmosphere
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溶解度:
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Chloroform (Sparingly), Methanol (Slightly)
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形态:
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Oil
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颜色:
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Colourless to Pale Yellow
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LogP:
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0.959 (est)
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6-MITC; 6 MITC; 6MITC性质、用途与生产工艺
Hesperin 是日本芥末中存在的一种生物活性成分,是一种 Nrf2 活化剂。
Hesperin (6-Methylsulfinylhexyl isothiocyanate, 6-MSITC) is an active compound in wasabi (
Wasabia japonica
Matsum.). Whether Hesperin induces cytotoxicity of HUVECs is determined. More than 1 μg/mL of Hesperin markedly induces cytotoxicity and morphological alterations. In subsequent experiments we used Hesperin is used at concentrations of 0-1 μg/mL, to study the anti-coagulant and anti-inflammatory properties of Hesperin in HUVECs.
Hesperin (6-Methylsulfinylhexyl isothiocyanate, 6-MSITC) activates Nrf2 and induces phase II enzyme genes but this induction is absent in Nrf2-null mice, suggesting that Hesperin is a potential activator of the Nrf2/ARE-dependent detoxification pathway. To determine whether Hesperin ameliorates hepatic steatosis and iron accumulation, wild-type and Nrf2-null mice are fed the following diets for 12 weeks: 1) control diet, 2) high-fat diet (HFD), 3) HFD plus Hesperin (10 mg/kg/day ip), 4) HFD for 6 weeks followed by an iron-supplemented HFD for 6 weeks (HFD/Iron), 5) HFD/Iron plus Hesperin. The HFD increased hepatic triglycerides in both genotypes and Hesperin suppress increased hepatic triglycerides in wild-type mice but do not reduce these
triglycerides in Nrf2-null mice.
6-MITC; 6 MITC; 6MITC
上下游产品信息
上游原料
下游产品
6-MITC; 6 MITC; 6MITC
生产厂家
4430-35-7, 6-MITC; 6 MITC; 6MITC 相关搜索:
- Aliphatics, Sulfur & Selenium Compounds
- 抑制剂
- 制剂-抑制剂
- C8H15NOS2
- 化合物 HESPERIN
- 1-异硫氰基-6-(甲基亚磺酰基)-己烷
- 化合物 T15474
- 4430-35-7
- Hexane, 1-isothiocyanato-6-(methylsulfinyl)-
- 6-MITC; 6 MITC; 6MITC
- 6-MITC
- 6-HITC
- 1-ISOTHIOCYANATO-6-(METHYLSULFINYL)-HEXANE
- 6-METHYLSULFINYLHEXYL ISOTHIOCYANATE