网站主页 >> CAS数据库列表 >> 3-Thiophenecarboxylic acid, 2-[(4-chlorobenzoyl)amino]-4-ethyl-5-methyl-, methyl ester
3-Thiophenecarboxylic acid, 2-[(4-chlorobenzoyl)amino]-4-ethyl-5-methyl-, methyl ester
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- CAS号:
- 544450-68-2
- 英文名:
- 3-Thiophenecarboxylic acid, 2-[(4-chlorobenzoyl)amino]-4-ethyl-5-methyl-, methyl ester
- 英文别名:
- COR659;Methyl 2-(4-chlorobenzamido)-4-ethyl-5-methylthiophene-3-carboxylate;3-Thiophenecarboxylic acid, 2-[(4-chlorobenzoyl)amino]-4-ethyl-5-methyl-, methyl ester;COR 659,Gamma-aminobutyric acid Receptor,sucrose,inhibit,chocolate,γ-Aminobutyric acid Receptor,GABA Receptor,COR-659,Inhibitor,COR659,alcohol
- 中文名:
- 3-Thiophenecarboxylic acid, 2-[(4-chlorobenzoyl)amino]-4-ethyl-5-methyl-, methyl ester
- 中文别名:
- 化合物COR659;2-(4-氯苯甲酰胺基)-4-乙基-5-甲基噻吩-3-羧酸甲酯
- CBNumber:
- CB48090818
- 分子式:
- C16H16ClNO3S
- 分子量:
- 337.82
- MOL File:
- 544450-68-2.mol
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3-Thiophenecarboxylic acid, 2-[(4-chlorobenzoyl)amino]-4-ethyl-5-methyl-, methyl ester化学性质
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储存条件:
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4°C, away from moisture and light
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溶解度:
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DMSO: 33.33 mg/mL (98.66 mM)
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3-Thiophenecarboxylic acid, 2-[(4-chlorobenzoyl)amino]-4-ethyl-5-methyl-, methyl ester性质、用途与生产工艺
COR659 是有效的 GABAB 的阳性变构调节剂 (PAM)。COR659 可缓解大鼠对酒精和巧克力的药物成瘾。
COR659 apparently exerts its effects via a composite mechanism, including positive allosteric modulation of the GABA
B
receptor and an action at the cannabinoid CB1 receptor.
COR659 (0, 2.5, 5 and 10 mg/kg) treatment is completely ineffective on lever-responding (FR10) for regular food pellets in food-deprived Wistar rats.
COR659 is able to suppress lever-responding for a sucrose solution in sP rats and a chocolate solution in Wistar rats.
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Animal Model:
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Male sP and Wistar rats.
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Dosage:
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0, 2.5, 5 and 10 mg/kg.
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Administration:
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Intraperitoneally (administered 30 min before the start of the self-administration, reinstatement, and locomotor activity sessions.).
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Result:
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The magnitude of the reducing effect of the compound on number oflever-responses for alcohol averaged approximately 30, 55, and 70%, in comparison to the vehicle-treated rat group, in the rat groups treated with 2.5, 5, and 10 mg/kg COR659, respectively.
The magnitude of the reducing effect of COR659 on number of lever-responses for alcohol averaged approximately 20, 40, and 80%, in comparison to the vehicletreated rat group, in the rat groups treated with 2.5, 5, and 10 mg/kg COR659, respectively.
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3-Thiophenecarboxylic acid, 2-[(4-chlorobenzoyl)amino]-4-ethyl-5-methyl-, methyl ester
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下游产品
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
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| 2024/04/30 | HY-137204 | 2-(4-氯苯甲酰胺基)-4-乙基-5-甲基噻吩-3-羧酸甲酯
COR659 | 544450-68-2 | 5mg | 2400元 |
| 2024/04/30 | HY-137204 | 2-(4-氯苯甲酰胺基)-4-乙基-5-甲基噻吩-3-羧酸甲酯
COR659 | 544450-68-2 | 10mM * 1mLin DMSO | 2640元 |
3-Thiophenecarboxylic acid, 2-[(4-chlorobenzoyl)amino]-4-ethyl-5-methyl-, methyl ester
生产厂家
544450-68-2, 3-Thiophenecarboxylic acid, 2-[(4-chlorobenzoyl)amino]-4-ethyl-5-methyl-, methyl ester 相关搜索:
- 化合物COR659
- 2-(4-氯苯甲酰胺基)-4-乙基-5-甲基噻吩-3-羧酸甲酯
- 544450-68-2
- COR 659,Gamma-aminobutyric acid Receptor,sucrose,inhibit,chocolate,γ-Aminobutyric acid Receptor,GABA Receptor,COR-659,Inhibitor,COR659,alcohol
- Methyl 2-(4-chlorobenzamido)-4-ethyl-5-methylthiophene-3-carboxylate
- COR659
- 3-Thiophenecarboxylic acid, 2-[(4-chlorobenzoyl)amino]-4-ethyl-5-methyl-, methyl ester