Bimosiamose
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- CAS号:
- 187269-40-5
- 英文名:
- Bimosiamose
- 英文别名:
- TBC-1269;Bimosiamose;[1,1'-Biphenyl]-3-acetic acid, 3',3'''-(1,6-hexanediyl)bis[6'-(α-D-mannopyranosyloxy)-
- 中文名:
- Bimosiamose
- 中文别名:
- 比莫西糖;化合物 T14574;化合物 BIMOSIAMOSE
- CBNumber:
- CB51401694
- 分子式:
- C46H54O16
- 分子量:
- 862.92
- MOL File:
- 187269-40-5.mol
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Bimosiamose化学性质
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熔点:
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115-117°
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沸点:
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1051.0±65.0 °C(Predicted)
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密度:
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1.417±0.06 g/cm3(Predicted)
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储存条件:
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Store at -20°C
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溶解度:
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DMSO:100.0(Max Conc. mg/mL);115.89(Max Conc. mM)
0.1 M NaOH:25.0(Max Conc. mg/mL);28.97(Max Conc. mM)-
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形态:
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A crystalline solid
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酸度系数(pKa):
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3.95±0.10(Predicted)
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颜色:
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White to off-white
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Bimosiamose性质、用途与生产工艺
Bimosiamose (TBC-1269) 是一种非寡糖泛-selectin 拮抗剂，对 E-selectin，P-selectin 和 L-selectin 的 IC50 分别为 88 μM，20 μM 和 86μM。Bimosiamose 具有抗炎作用。
IC50: 88 μM (E-selectin), 20 μM (P-selectin), 86 μM (L-selectin)
Bimosiamose (TBC-1269) operates by inhibiting neutrophil recruitment to the site of inflammation through blocking the initial rolling phase of recruitment. Bimosiamose (TBC-1269) inhibits cell recruitment and does not possess any cytotoxic effect on neutrophils.
Bimosiamose (TBC-1269; 25 mg/kg; intravenous injection; Sprague-Dawley rats) treatment shows a significant increase in survival. Best overall survival, 70%, is observed when TBC-1269 is administered 15 minutes before reperfusion, and also shows a marked decrease in liver enzyme levels at 6 hours after reperfusion. Neutrophil migration is also significantly ameliorated (81%). The histologic damage scores is also improved.
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Animal Model:
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Sprague-Dawley rats (200-225g) with ischemia and reperfusion (I/R)
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Dosage:
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25 mg/kg
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Administration:
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Intravenous injection
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Result:
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Showed a significant increase in survival compared with controls.
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Bimosiamose
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| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
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| 2024/11/08 | HY-106139 | Bimosiamose
Bimosiamose | 187269-40-5 | 1mg | 600元 |
| 2024/11/08 | HY-106139 | Bimosiamose
Bimosiamose | 187269-40-5 | 5mg | 1800元 |
187269-40-5, Bimosiamose 相关搜索:
- 抑制剂
- 对照品
- C46H54O16
- 化合物 BIMOSIAMOSE
- 化合物 T14574
- 比莫西糖
- 187269-40-5
- [1,1'-Biphenyl]-3-acetic acid, 3',3'''-(1,6-hexanediyl)bis[6'-(α-D-mannopyranosyloxy)-
- TBC-1269
- Bimosiamose