VAS2870
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- CAS号:
- 722456-31-7
- 英文名:
- 1,3-benzoxazol-2-yl 3-benzyl-3H-[1,2,3]triazolo[4,5-d]pyrimidin-7-yl sulfide
- 英文别名:
- VAS2870;VAS 2870;VAS-2870;VAS2870 VAS-2870;VAS 2870;VAS-2870;VAS2870;NOX Inhibitor III, VAS2870;NOX Inhibitor III, VAS2870 - CAS 722456-31-7 - Calbiochem;2-(3-benzyl-3H-[1,2,3]triazolo[4,5-d]pyrimidin-7-ylthio)benzo[d]oxazole;7-(2-Benzoxazolylthio)-3-(phenylmethyl)-3H-1,2,3-triazolo[4,5-d]pyrimidine;3H-1,2,3-Triazolo[4,5-d]pyrimidine, 7-(2-benzoxazolylthio)-3-(phenylmethyl)-
- 中文名:
- VAS2870
- 中文别名:
- 化合物VAS2870;VAS 2870,NADPH氧化酶抑制剂;2-((3-苄基-3H- [1,2,3]三唑并[4,5-D]嘧啶-7-基)硫基)苯并[D]恶唑;2-((3-苄基-3H- [1,2,3]三唑并[4,5-D]嘧啶-7-基)硫代)苯并[D]恶唑
- CBNumber:
- CB51977298
- 分子式:
- C18H12N6OS
- 分子量:
- 360.39
- MOL File:
- 722456-31-7.mol
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VAS2870化学性质
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沸点:
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627.0±65.0 °C(Predicted)
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密度:
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1.53±0.1 g/cm3(Predicted)
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储存条件:
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room temp
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溶解度:
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DMSO: ≥5mg/mL
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形态:
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Tan solid
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酸度系数(pKa):
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0.85±0.30(Predicted)
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颜色:
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white to beige
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稳定性:
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Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
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VAS2870性质、用途与生产工艺
VAS-2870 (722456-31-7) 是一种 NAD(P)H 氧化酶 (Nox) 抑制剂。其可抑制 HL-60 细胞中 由PMA 诱导的氧化反应(IC50=2 μM)，可 增强 TGF-β 诱导的肝肿瘤细胞的凋亡。
VAS2870是一种泛NADPH oxidase(NOX)抑制剂。
| Target | Value |
NADPH oxidase
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VAS2870 is effective to suppress PDGF-BB-dependent activation of NADPH oxidase and subsequent production of intracellular ROS. Furthermore, VAS2870 suppresses PDGF-BB-dependent chemotaxis, but not DNA synthesis. Preincubation with VAS2870 (10 and 20 μM) completely abolishes PDGF-mediated NADPH oxidase activation and ROS production. Preincubation with VAS2870 (0.1-20 μM) does not affect PDGF-induced cell cycle progression. However, it abolishes PDGF-dependent chemotaxis of VSMC in a concentration-dependent manner (100% inhibition at 10 μM). VAS2870 inhibits dose-dependently autocrine increase of cell number in FaO rat hepatoma cells, and almost completely blocked ROS production and thymidine incorporation when used at 25 mM. VAS2870 blocks serum-dependent cell growth of FaO rat hepatoma cells. VAS2870 inhibits proliferation of different human hepatocellular carcinoma (HCC) cell lines. VAS2870 pretreatment enhances TGF-b-mediated apoptosis of FaO rat hepatoma cells.
VAS2870
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下游产品
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
|---|
| 2024/08/19 | HY-12804 | VAS2870 | | 1 mg | 300元 |
| 2024/08/19 | HY-12804 | VAS2870
VAS2870 | 722456-31-7 | 5mg | 659元 |
722456-31-7, VAS2870 相关搜索:
- 抑制剂
- 药靶配体
- C18H12N6OS
- 722546-31-7
- VAS 2870,NADPH氧化酶抑制剂
- 2-((3-苄基-3H- [1,2,3]三唑并[4,5-D]嘧啶-7-基)硫基)苯并[D]恶唑
- 2-((3-苄基-3H- [1,2,3]三唑并[4,5-D]嘧啶-7-基)硫代)苯并[D]恶唑
- 化合物VAS2870
- 722456-31-7
- VAS2870 VAS-2870
- 3H-1,2,3-Triazolo[4,5-d]pyrimidine, 7-(2-benzoxazolylthio)-3-(phenylmethyl)-
- VAS 2870;VAS-2870;VAS2870
- NOX Inhibitor III, VAS2870 - CAS 722456-31-7 - Calbiochem
- 2-(3-benzyl-3H-[1,2,3]triazolo[4,5-d]pyrimidin-7-ylthio)benzo[d]oxazole
- NOX Inhibitor III, VAS2870
- VAS-2870
- VAS2870
- VAS 2870
- 7-(2-Benzoxazolylthio)-3-(phenylmethyl)-3H-1,2,3-triazolo[4,5-d]pyrimidine
- 7-(1,3-Benzoxazol-2-ylsulfanyl)-3-benzyl-3H-[1,2,3]triazolo[4,5-d]pyrimidine
- 1,3-benzoxazol-2-yl 3-benzyl-3H-[1,2,3]triazolo[4,5-d]pyrimidin-7-yl sulfide