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LY-367385;(R)-(+)-ALPHA-AMINO-4-CARBOXY-2-METHYLBENZENEACETIC ACID
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- CAS号:
- 198419-91-9
- 英文名:
- LY 367385
- 英文别名:
- LY 367385;LY367385,LY-367385;LY-367385 hydrochloride;SGIKDIUCJAUSRD-QMMMGPOBSA-N;LY 367385, mGlu1a antagonist;(S)-4-[aMino(carboxy)Methyl]-3-Methylbenzoic acid;4-[(R)-amino(carboxy)methyl]-3-methylbenzoic acid;4-[(S)-amino(carboxy)methyl]-3-methylbenzoic acid;(S)-(+)-α-Amino-4-carboxy-2-methylbenzeneaceticacid;(S)-(+)-a-amino-4-carboxy-2-methylbenzeneacetic acid
- 中文名:
- LY-367385;(R)-(+)-ALPHA-AMINO-4-CARBOXY-2-METHYLBENZENEACETIC ACID
- 中文别名:
- 化合物 T15818;化合物 LY367385;LY 367385,MGLU1A拮抗剂;化合物 LY367385 HYDROCHLORIDE
- CBNumber:
- CB5200038
- 分子式:
- C10H11NO4
- 分子量:
- 209.2
- MOL File:
- 198419-91-9.mol
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LY-367385;(R)-(+)-ALPHA-AMINO-4-CARBOXY-2-METHYLBENZENEACETIC ACID化学性质
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储存条件:
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Desiccate at RT
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溶解度:
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H2O: >10mg/mL
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形态:
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powder
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颜色:
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white to off-white
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LY-367385;(R)-(+)-ALPHA-AMINO-4-CARBOXY-2-METHYLBENZENEACETIC ACID性质、用途与生产工艺
LY367385 是一种高效且选择性的 mGluR1a 拮抗剂，抑制喹喹啉诱导的磷酸肌醇水解的 IC50 值为 8.8 μM，而对 mGlu5a 的 IC50 值大于 100 μM。LY367385 具有神经保护，抗惊厥和抗癫痫作用。
LY367385 combined with N-methyl-D-aspartate (NMDA) during the toxic pulse attenuates neuronal degeneration in a concentration-dependent fashion, with a maximal reduction of NMDA toxicity ranging from 40 to 60%. LY367385 shows greater efficacy than LY367366 and neither of these compounds influenced neuronal viability per se. LY367385 shows potent neuroprotective effects, with causing a 50% reduction in (S)-3,5-Dihydroxyphenylglycine (DHPG) potentiation at a concentration of 10 nM. Under experimental conditions at higher concentrations of antagonist, LY367385 a completely antagonized the amplification of NMDA toxicity by DHPG.
LY367385 has been administered intracerebroventricularly (i.c.v.) to DBA/2 mice and lethargic mice (lh/lh), and focally into the inferior colliculus of genetically epilepsy prone rats (GEPR). In DBA/2 mice, LY367385 produces a rapid, transient suppression of sound-induced clonic seizures ED50 = 12 nM, i.c.v., 5 min). In lethargic mice, LY367385 significantly reduces the incidence of spontaneous spike and wave discharges on the electroencephalogram, from 30 to >150 min after the administration of LY367385, 250 nM, i.c.v.
In genetically epilepsy prone rats, LY367385 reduces sound-induced clonic seizures. LY367385, 160 nM bilaterally, fully suppresses clonic seizures after 2-4 h.
LY-367385;(R)-(+)-ALPHA-AMINO-4-CARBOXY-2-METHYLBENZENEACETIC ACID
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| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
|---|
| 2024/11/08 | HY-107515A | LY-367385;(R)-(+)-ALPHA-AMINO-4-CARBOXY-2-METHYLBENZENEACETIC ACID
LY367385 hydrochloride | 198419-91-9 | 5mg | 850元 |
| 2024/11/08 | HY-107515A | LY-367385;(R)-(+)-ALPHA-AMINO-4-CARBOXY-2-METHYLBENZENEACETIC ACID
LY367385 hydrochloride | 198419-91-9 | 10mM * 1mLin DMSO | 940元 |
LY-367385;(R)-(+)-ALPHA-AMINO-4-CARBOXY-2-METHYLBENZENEACETIC ACID
生产厂家
198419-91-9, LY-367385;(R)-(+)-ALPHA-AMINO-4-CARBOXY-2-METHYLBENZENEACETIC ACID 相关搜索:
- Glutamate
- 抑制剂
- LY 367385,MGLU1A拮抗剂
- 化合物 LY367385
- 化合物 LY367385 HYDROCHLORIDE
- 化合物 T15818
- 198419-91-9
- LY 367385, mGlu1a antagonist
- 4-[(S)-amino(carboxy)methyl]-3-methylbenzoic acid
- 4-[(R)-amino(carboxy)methyl]-3-methylbenzoic acid
- Benzeneacetic acid, α-amino-4-carboxy-2-methyl-, (αS)-
- LY367385,LY-367385
- SGIKDIUCJAUSRD-QMMMGPOBSA-N
- Benzeneacetic acid, α-amino-4-carboxy-2-methyl-, (αS)-
- (S)-(+)-α-Amino-4-carboxy-2-methylbenzeneacetic acid
- LY-367385;(R)-(+)-ALPHA-AMINO-4-CARBOXY-2-METHYLBENZENEACETIC ACID
- (R)-(+)-alpha-Amino-4-carboxy-2-methylbenzeneacetic acid
- LY-367385 hydrochloride
- (S)-(+)-a-amino-4-carboxy-2-methylbenzeneacetic acid
- (S)-4-[aMino(carboxy)Methyl]-3-Methylbenzoic acid
- (S)-(+)-α-Amino-4-carboxy-2-methylbenzeneaceticacid
- LY 367385
- (S)-(+)-ALPHA-AMINO-4-CARBOXY-2-METHYLBENZENEACETIC ACID