OTSSP 167 盐酸盐
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- CAS号:
- 1431698-10-0
- 英文名:
- OTSSP167HCL
- 英文别名:
- OTS167 HCl;OTSSP167HCL;OTS-167 hydrochloride;OTSSP167 HCl (OTS167);OTSSP167 HCl (OTS167 HCl);MELK INHIBITOR; OTSSP-167; OTSSP 167;OTSSP167 hydrochloride, 10 mM in DMSO;OTSSP167hydrochloride/OTSSP-167hydrochloride;1-[6-(3,5-Dichloro-4-hydroxyphenyl)-4-[[trans-4-[(dimethylamino)methyl]cyclohexyl]amino]-1,5-naphthyridin-3-yl]-ethanone hydrochloride;Ethanone,1-[6-(3,5-dichloro-4-hydroxyphenyl)-4-[[trans-4-[(dimethylamino)methyl]cyclohexyl]amino]-1,5-naphthyridin-3-yl]-,hydrochloride(1:1)
- 中文名:
- OTSSP 167 盐酸盐
- 中文别名:
- OTSSP 167 盐酸盐;OTSSP 167 盐酸盐,10 MM DMSO 溶液
- CBNumber:
- CB52718395
- 分子式:
- C25H29Cl3N4O2
- 分子量:
- 523.88236
- MOL File:
- 1431698-10-0.mol
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OTSSP 167 盐酸盐化学性质
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储存条件:
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Store at -20°C
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溶解度:
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Soluble in DMSO
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形态:
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crystalline solid
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颜色:
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Light yellow to gray
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OTSSP 167 盐酸盐性质、用途与生产工艺
OTSSP167 hydrochloride 是一种高效的，ATP 竞争性的 MELK 抑制剂，IC50 值为 0.41 nM。
OTSSP167 inhibits the growth of A549 (lung), T47D (breast), DU4475 (breast), 22Rv1 (prostate) and HT1197 (bladder) cancer cells with IC
50
values of 6.7, 4.3, 2.3, 6.0 and 97 nM, respectively. OTSSP167 can abrogate the mitotic checkpoint, disrupt MCC and MCC-APC/C interaction in MCF7 cells. OTSSP167 causes GFP-MELK localization to cell cortex in prometaphase cells. OTSSP167 is a MELK selective inhibitor, exhibits a strong in vitro activity, conferring an IC
50
of 0.41 nM.
OTSSP167 (20 mg/kg, i.v.) results in tumor growth inhibition (TGI) of 73% in xenograft mouse model; OTSSP167 (1, 5, and 10 mg/kg, p.o.) reveals TGI of 51, 91, and 108%, respectively. OTSSP167 (20 mg/kg, p.o.) shows no tumor growth suppressive effect on PC-14 xenografts.
OTSSP 167 盐酸盐
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1431698-10-0, OTSSP 167 盐酸盐 相关搜索:
- 抑制剂
- 医药
- C25H29Cl3N4O2
- C25H28Cl2N4O2HCl
- OTSSP 167 盐酸盐,10 MM DMSO 溶液
- OTSSP 167 盐酸盐
- 1431698-10-0
- OTSSP167 hydrochloride, 10 mM in DMSO
- OTS167 HCl
- OTSSP-167,OTSSP 167,OTSSP167,OTSSP167 hydrochloride,MELK,OTSSP-167 hydrochloride,Maternal embryonic leucine zipper kinase,inhibit,OTS167,OTS-167,OTS 167,Inhibitor
- OTSSP167hydrochloride/OTSSP-167hydrochloride
- OTSSP167 HCl (OTS167 HCl)
- MELK INHIBITOR; OTSSP-167; OTSSP 167
- OTS-167 hydrochloride
- Ethanone,1-[6-(3,5-dichloro-4-hydroxyphenyl)-4-[[trans-4-[(dimethylamino)methyl]cyclohexyl]amino]-1,5-naphthyridin-3-yl]-,hydrochloride(1:1)
- OTSSP167 HCl (OTS167)
- 1-[6-(3,5-Dichloro-4-hydroxyphenyl)-4-[[trans-4-[(dimethylamino)methyl]cyclohexyl]amino]-1,5-naphthyridin-3-yl]-ethanone hydrochloride
- OTSSP167HCL