CS-2759
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- CAS号:
- 195615-84-0
- 英文名:
- Anavex 2-73
- 英文别名:
- CS-2759;Anavex 2-73;Blarcamesine;Anavex2-73 HCl;AVex-73 hydrochL;AE-37 HYDROCHLORIDE;AN2/AVEX-73 HCL SALT;AVex-73 hydrochloride;Anavex 2-73(ANAVEX2-73);Anavex 2-73 hydrochloride
- 中文名:
- CS-2759
- 中文别名:
- AN2/AVEX-73盐酸盐;化合物ANAVEX 2-73;1-(2,2-二苯基四氢呋喃-3-基)-N,N-二甲基甲胺盐酸盐;BLARCAMESINE HYDROCHLORIDE, AVEX-73 HYDROCHLORIDE, AE-37 HYDROCHLORIDE
- CBNumber:
- CB53151652
- 分子式:
- C19H24ClNO
- 分子量:
- 317.86
- MOL File:
- 195615-84-0.mol
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CS-2759化学性质
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熔点:
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165 - 168°C
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储存条件:
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-20°C Freezer, Under inert atmosphere
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溶解度:
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DMSO (Slightly), Methanol (Slightly)
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形态:
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Solid
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颜色:
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White to Off-White
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CS-2759性质、用途与生产工艺
Anavex 2-73 (Blarcamesine, AVex-73, AE-37) 是一种氨基四氢呋喃衍生物,也是一种混合型 muscarinic 和 sigma-1/σ1 Receptor 的激动剂,其IC50值为0.86μM。
Target | Value |
muscarinic
()
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sigma-1 receptor
(Cell-free assay)
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0.86 μM
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The pre-administration of Blarcamesine (ANAVEX2-73) leads to a dose-dependent attenuation of the scopolamine induced alternation deficit, significant at 1 and 3 mg/kg. The pre-treatment with Blarcamesine hydrochloride attenuates the impairments of step-through latency, dose dependently and significantly at doses higher than 0.3 mg/kg. The Blarcamesine hydrochloride treatment dose-dependently blocks the recognition memory deficit, with a significant effect measured at 1 mg/kg. One day after injections, the significant Aβ
25-35
-induced decrease in Akt phosphorylation is significantly attenuated by Blarcamesine hydrochloride at 0.1 and 1 mg/kg dose. Seven days after injections, Blarcamesine hydrochloride attenuates the decrease in Ser
9
phosphorylation induced by the peptide at 0.3 and 1 mg/kg. The Blarcamesine hydrochloride treatment dose-dependently prevents the Aβ
25-35
-induced increase in Aβ
1-42
content, with a significant effect at the highest dose tested.
CS-2759
上下游产品信息
上游原料
下游产品
更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
---|
2024/08/19 | HY-101864 | CS-2759 Blarcamesine hydrochloride | 195615-84-0 | 5mg | 610元 |
2024/08/19 | HY-101864 | CS-2759 Blarcamesine hydrochloride | 195615-84-0 | 10mM * 1mLin DMSO | 671元 |
195615-84-0, CS-2759 相关搜索:
- API
- 药靶配体
- 医药原料
- AN2/AVEX-73盐酸盐
- BLARCAMESINE HYDROCHLORIDE, AVEX-73 HYDROCHLORIDE, AE-37 HYDROCHLORIDE
- 化合物ANAVEX 2-73
- 1-(2,2-二苯基四氢呋喃-3-基)-N,N-二甲基甲胺盐酸盐
- 195615-84-0
- Inhibitor,Blarcamesine,Blarcamesine hydrochloride,inhibit,Sigma Receptor
- Tetrahydro-N,N-dimethyl-2,2-diphenyl-3-furanmethanamine hydrochloride
- Anavex 2-73 hydrochloride
- 1-(2,2-Diphenyltetrahydrofuran-3-yl)-N,N-dimethylmethanamine hydrochloride
- Tetrahydro-N,N-dimethyl-2,2-diphenyl-3-furanmethanamine hydrochloride salt
- AVex-73 hydrochL
- Blarcamesine hydrochloride
- AVex-73 hydrochloride(AE-37)
- Anavex 2-73(ANAVEX2-73)
- Blarcamesine
- AE-37; AVEX-73; ANAVEX-2-73; ANAVEX-273; AE37; AVEX73; ANAVEX273; AE 37; AVEX 73; ANAVEX 2 73; ANAVEX 273; BLARCAMESINE
- CS-2759
- Anavex2-73 HCl
- AVex-73 hydrochloride
- AN2/AVEX-73 HCL SALT
- AE-37 HYDROCHLORIDE
- AN2/AVex-73 hydrochloride salt
- Anavex 2-73