EF-5
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- CAS号:
- 152721-37-4
- 英文名:
- EF-5
- 英文别名:
- EF-5;EF5 >=98% (HPLC);inhibit,EF 5,EF-5,Inhibitor;1H-Imidazole-1-acetamide, 2-nitro-N-(2,2,3,3,3-pentafluoropropyl)-
- 中文名:
- EF-5
- 中文别名:
- 化合物EF-5
- CBNumber:
- CB53339650
- 分子式:
- C8H7F5N4O3
- 分子量:
- 302.16
- MOL File:
- 152721-37-4.mol
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EF-5化学性质
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密度:
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1.66±0.1 g/cm3(Predicted)
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储存条件:
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Store at -20°C
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溶解度:
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DMSO : 125 mg/mL (413.69 mM)
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形态:
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Solid
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酸度系数(pKa):
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12.32±0.46(Predicted)
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颜色:
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White to off-white
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EF-5性质、用途与生产工艺
EF-5 (EF5; 2-Nitroimidazole) 是用于鉴定细胞缺氧的缺氧标记试剂。
Overexpression of CYPOR induces similar 2- to 4-fold increases in EF-5 binding and metabolic reduction of tirapazamine and CEN-209 in SiHa and HCT116 cell lines, and similar enhancement of γH2AX formation. EF-5 binding and metabolic reduction of the prodrugs are highly correlated in a panel of 14 hypoxic tumor cell lines.
EF-5 binding is a promising stratification biomarker for benzotriazine-N-oxide bioreductive prodrugs. In HCT116 xenografts, CYPOR overexpression also significantly increases EF-5 binding and CEN-209 reduction, and modification of tumor hypoxia causes similar changes to the bioreductive activation of both agents, resulting in a strong correlation between EF-5 binding and CEN209-induced DNA damage at the individual tumor level. Following intravenous injection of EF-5, binding and detection using a monoclonal antibody in 9L gliomas is specific and oxygen dependent. Detection of binding using fluorescence microscopy can be performed on frozen tissues; tissue sections can be counterstained with haematoxylin and eosin for light microscopic analysis. Alternatively, the distribution of hypoxia in a tumor can be inferred by examining individual tumor cells using flow cytometric techniques.
EF-5
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更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
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2024/04/30 | HY-U00118 | EF-5 EF-5 | 152721-37-4 | 5mg | 900元 |
2024/04/30 | HY-U00118 | EF-5 EF-5 | 152721-37-4 | 10mM * 1mLin DMSO | 990元 |
152721-37-4, EF-5 相关搜索:
- C8H7F5N4O3
- 化合物EF-5
- 152721-37-4
- inhibit,EF 5,EF-5,Inhibitor
- EF5 >=98% (HPLC)
- 1H-Imidazole-1-acetamide, 2-nitro-N-(2,2,3,3,3-pentafluoropropyl)-
- EF-5