171722-81-9
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- CAS号:
- 171722-81-9
- 英文名:
- YM-46303
- 英文别名:
- YM-46303;YM46303,YM 46303
- 中文名:
- 171722-81-9
- 中文别名:
- 化合物 T13370;化合物 YM-46303
- CBNumber:
- CB53339731
- 分子式:
- C20H23ClN2O2
- 分子量:
- 358.87
- MOL File:
- 171722-81-9.mol
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171722-81-9化学性质
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储存条件:
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Store at -20°C
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溶解度:
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Soluble in DMSO
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171722-81-9性质、用途与生产工艺
YM-46303是一种毒蕈碱受体拮抗剂，对 M1 和 M3 受体表现出最高的亲和力，对M3受体的选择性较M2受体高。
YM-46303 shows approximately ten times higher inhibitory activity on bladder pressure in reflexly-evoked rhythmic contraction, and about 5-fold greater selectivity for urinary bladder contraction against salivary secretion in rats compared to oxybutynin. Further evaluation of antimuscarinic effects on bradycardia and pressor in pithed rats, and on tremor in mice, show that YM-46303 can be useful for the treatment of urinary urge incontinence as a bladder-selective M3 antagonist with potent activities and fewer side effects. YM-46303 shows
in vivo
selective inhibitory activities on bladder pressure in reflexly-evoked rhythmic contraction against oxotremorine-induced salivary secretion. In addition, YM-46303 has potent activity in a guinea pig model of methacholine-induced bronchospasm on intravenous administration.
171722-81-9
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171722-81-9, 171722-81-9 相关搜索:
- 抑制剂
- 化合物 YM-46303
- 化合物 T13370
- 171722-81-9
- YM46303,YM 46303
- YM-46303