ADX71743
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- CAS号:
- 1431641-29-0
- 英文名:
- ADX71743
- 英文别名:
- ADX71743;ADX-71743,ADX71743;ADX71743 >=98% (HPLC);4(5H)-Benzoxazolone, 6-(2,4-dimethylphenyl)-2-ethyl-6,7-dihydro-, (+)-
- 中文名:
- ADX71743
- 中文别名:
- 化合物 T26570
- CBNumber:
- CB53364104
- 分子式:
- C17H19NO2
- 分子量:
- 269.34
- MOL File:
- 1431641-29-0.mol
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ADX71743化学性质
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沸点:
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405.1±24.0 °C(Predicted)
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密度:
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1.130±0.06 g/cm3(Predicted)
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酸度系数(pKa):
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-0.05±0.40(Predicted)
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ADX71743性质、用途与生产工艺
ADX71743 是一种高度选择性，非竞争性且透过血脑屏障的代谢型谷氨酸受体 7 负变构调节剂 (mGlu7 NAM)。ADX71743 具有抗焦虑活性。
ADX71743 has an IC
50
of 300 nM in-house cell lines. Pretreatment of ADX71743 (3 μM; for 20 min) before high-frequency stimulation (HFS) results in an almost complete blockade of LTP induction.
ADX71743 (0.1, 10 μM) reverses L-AP4-induced depression of synaptic transmission and results in a concentration-dependent reversal of the L-AP4-induced depression. 0.1 μM ADX71743 reverses the effects of L-AP4 by 11% and 10 μM results in a 20% reversal.
ADX71743 can against an EC
80
of glutamate (IC
50
of 22 nM) as well as against an EC
80
of L-AP4 (IC
50
of 125 nM).
ADX71743 (50, 100, 150 mg/kg; SC) results in robust reductions in numbers of buried marbles to near maximal levels at lower doses (50 and 100 mg/kg).
ADX71743 (12.5, 100 mg/kg for mice and 100 mg/kg for rat; SC) has a T
1/2
of 0.68, 0.40 hours, a C
max
of 1380, 12766 ng/ml of 12.5 mg/kg and 100 mg/kg in mice.
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Animal Model:
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Adult male C57Bl6/J mice (24-30 g)
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Dosage:
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50, 100, 150 mg/kg
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Administration:
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SC
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Result:
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Resulted in robust reductions in numbers of buried marbles to near maximal levels at lower doses (50 and 100 mg/kg).
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Animal Model:
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Adult male C57Bl6/J mice (24-30 g) and Sprague-Dawley rats (250-350 g)
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Dosage:
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12.5, 100 mg/kg for mice and 100 mg/kg for rat (Pharmacokinetic Analysis)
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Administration:
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SC
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Result:
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Had a T
1/2
of 0.68, 0.40 hours, a C
max
of 1380, 12766 ng/ml of 12.5 mg/kg and 100 mg/kg in mice.
Had a T
1/2
of 1.5 hours, a C
max
of 16800 ng/ml of 100 mg/kg in rat.
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ADX71743
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上游原料
下游产品
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
|---|
| 2024/08/19 | HY-110278 | ADX71743 | | 5 mg | 3383元 |
| 2024/08/19 | HY-110278 | ADX71743 | | 10 mg | 5416元 |
1431641-29-0, ADX71743 相关搜索:
- 化合物 T26570
- 1431641-29-0
- 4(5H)-Benzoxazolone, 6-(2,4-dimethylphenyl)-2-ethyl-6,7-dihydro-, (+)-
- ADX-71743,ADX71743
- ADX71743 >=98% (HPLC)
- ADX71743