KSI-3716
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- CAS号:
- 1151813-61-4
- 英文名:
- 3-acetyl-8-bromo-5-chloro-2-(4-chloroanilino)-1H-quinolin-4-one
- 英文别名:
- KSI-3716;KSI 3716,KSI3716;3-acetyl-8-bromo-5-chloro-2-(4-chloroanilino)-1H-quinolin-4-one;4(1H)-Quinolinone, 3-acetyl-8-bromo-5-chloro-2-[(4-chlorophenyl)amino]-
- 中文名:
- KSI-3716
- 中文别名:
- 化合物 T11783
- CBNumber:
- CB53720100
- 分子式:
- C17H11BrCl2N2O2
- 分子量:
- 426.09
- MOL File:
- 1151813-61-4.mol
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KSI-3716化学性质
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沸点:
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532.8±50.0 °C(Predicted)
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密度:
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1.675±0.06 g/cm3(Predicted)
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储存条件:
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Store at -20°C
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溶解度:
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DMSO: 5 mg/mL (11.73 mM)
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酸度系数(pKa):
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-2.74±0.20(Predicted)
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形态:
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Solid
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颜色:
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Light yellow to khaki
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KSI-3716性质、用途与生产工艺
KSI-3716 是一种有效的 c-Myc 抑制剂，可阻断 c-MYC/MAX 与靶基因启动子的结合。KSI-3716 是一种有效的膀胱内化疗剂，可用于膀胱癌的研究。
KSI-3716 blocks c-MYC/MAX from forming a complex with target gene promoters. KSI-3716 effectively blocks complex formation in a dose dependent manner (IC
50
=0.84 μM). c-MYC mediated transcriptional activity is inhibited by KSI-3716 at concentrations as low as 1 μM. The expression of c-MYC target genes, such as cyclin D2, CDK4 and hTERT, is markedly decreased. KSI-3716 exerts cytotoxic effects on bladder cancer cells by inducing cell cycle arrest and apoptosis.
Intravesical instillation of KSI-3716 at a dose of 5 mg/kg significantly suppresses tumor growth with minimal systemic toxicity.
KSI-3716
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| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
|---|
| 2024/04/30 | HY-12703 | KSI-3716 | | 1 mg | 1590元 |
| 2024/04/30 | HY-12703 | KSI-3716
KSI-3716 | 1151813-61-4 | 10mM * 1mLin DMSO | 3281元 |
1151813-61-4, KSI-3716 相关搜索:
- 化合物 T11783
- 1151813-61-4
- KSI 3716,KSI3716
- 4(1H)-Quinolinone, 3-acetyl-8-bromo-5-chloro-2-[(4-chlorophenyl)amino]-
- KSI-3716
- 3-acetyl-8-bromo-5-chloro-2-(4-chloroanilino)-1H-quinolin-4-one