盐酸安普乐定
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- CAS号:
- 73218-79-8
- 英文名:
- Apraclonidine hydrochloride
- 英文别名:
- APRACLONIDINE HCL;iopidine;AL 02145;alo-2145;Iopidine UD;nc14hydrochloride;iopidineophthalmicsolution;APRACLONIDINE HYDROCHLORIDE;Apracloniding Hydrochloride;P-AMINOCLONIDINE HYDROCHLORIDE
- 中文名:
- 盐酸安普乐定
- 中文别名:
- 盐酸阿可乐定;盐酸安普乐定;盐酸安普乐啶;安普乐定盐酸盐;盐酸阿普拉尼丁;盐酸安普乐定标准品;盐酸安普乐定对照品;盐酸安普乐定/盐酸阿可乐定;盐酸阿可乐定 USP标准品;盐酸阿可乐定(曾用名:盐酸安普乐定)
- CBNumber:
- CB5439290
- 分子式:
- C9H11Cl3N4
- 分子量:
- 281.57
- MOL File:
- 73218-79-8.mol
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盐酸安普乐定化学性质
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熔点:
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>2300C
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储存条件:
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Keep in dark place,Inert atmosphere,Room temperature
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溶解度:
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45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin: 1.4 mg/mL Solutions may be stored for several days at 4°C
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形态:
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solid
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颜色:
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white
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稳定性:
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Moisture Sensitive
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CAS 数据库:
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73218-79-8(CAS DataBase Reference)
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盐酸安普乐定性质、用途与生产工艺
安普乐定具有较强的α2-肾上腺素能受体的作用，通过激活眼内α2-肾上腺素能受 体，降低眼内压。本品血脑屏障通透率低，中枢和心血管作用弱，全身性副作用低且无明显 扩瞳作用，因而有很好的应用前景，其是治疗激光手术所引起的眼内压升高的特效药物。
以2,6-二氯-4-硝基苯胺、甲酸和乙酸酐等为反应起始原料，进行甲酰化反应得到N-(2,6-二氯-4-硝基苯基)甲酰胺；而后经氯化、环合得到2-(2’,6’-二氯-4’-硝基 苯胺基)-2-咪唑啉，最后用水合肼将2-(2’,6’-二氯-4’-硝基苯胺基)-2-咪唑啉中硝基还 原，制得盐酸安普乐定(1)，总收率达45％。其中用水合肼作为还原剂2-(2’,6’-二氯-4’-硝 基苯胺基)-2-咪唑啉中硝基还原为首次报道，对亚胺键未见影响，该步收率达80％以上。
Apraclonidine (Iopidine)是一种拟交感神经要，用于治疗青光眼。它是α2-肾上腺素能受体激动剂。
Apraclonidine hydrochloride (ALO 2145) is more commonly used topically for glaucoma, as it penetrates the cornea and blood-brain barrier to a lesser extent and, thus, has fewer adverse systemic effects.
Apraclonidine hydrochloride (ALO 2145) is effective in animal models of elevated IOP as well as glaucoma in humans. The ocular hypotensive effects of Apraclonidine are usually attributed to reduced aqueous humor synthesis and vasoconstrictor actions at the anterior segment branches of the ophthalmic artery.
盐酸安普乐定
上下游产品信息
上游原料
下游产品
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
|---|
| 2024/04/30 | HY-12720A | Apraclonidine hydrochloride | | 1 mg | 360元 |
| 2024/04/30 | S6583 | 盐酸安普乐定
Apraclonidine HCl | 73218-79-8 | 5mg | 795.2元 |
盐酸安普乐定
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73218-79-8, 盐酸安普乐定 相关搜索:
- Pharmaceuticals
- Nucleotides
- Intermediates & Fine Chemicals
- Heterocycles
- Bases & Related Reagents
- Heterocyclic Compounds
- 药靶配体
- 有机化工原料
- 医药原料
- 原料
- C9H11Cl3N4C9H10Cl2N4HCl
- C9H10Cl2N4HCl
- C9H11Cl3N4
- C9H103N4HCl
- 73128-79-8
- 3218-79-8
- 盐酸阿普拉尼丁
- 盐酸安普乐定对照品
- 盐酸安普乐定标准品
- 安普乐定盐酸盐
- 盐酸安普乐啶
- 盐酸安普乐定/盐酸阿可乐定
- 2,6-二氯-N1-(4,5-二氢-1H-咪唑-2-基)苯-1,4-二胺盐酸盐
- 甲醇中盐酸安普乐定溶液,100ΜG/ML
- 盐酸阿可乐定 USP标准品
- 盐酸阿可乐定
- 盐酸阿可乐定(曾用名:盐酸安普乐定)
- 2-(4-氨基-2,6-二氯苯胺基)-2-咪唑啉盐酸盐
- 盐酸安普乐定
- 73218-79-8
- iopidine
- APRACLONIDINE HCL
- Apraclonidine Hydrochloride (1041609)
- 6-Dichloro-N1-(4,5-dihydro-1H-imidazol-2-yl)benzene-1,4-diamine hydrochloride
- Apraclonidine hydrochloride USP/EP/BP
- Apraclonidine hydrochloride Solution in Methanol, 100μg/mL
- Apracloniding Hydrochloride
- nc14hydrochloride
- iopidineophthalmicsolution
- alo-2145
- 4-benzenediamine,2,6-dichloro-n(sup1)-(4,5-dihydro-1h-imidazol-2-yl)-mono
- 3,5-dichloro-4-(2-imidazolidinylidenimino)anilinehydrochloride
- Apraclonidine Hydrochloride (100 mg)
- 2,6-dichloro-N1-(4,5-dihydro-1H-imidazol-2-yl)benzene-1,4-diamine hydrochloride
- 2,6-dichloro-1-N-(4,5-dihydro-1H-imidazol-2-yl)benzene-1,4-diamine hydrochloride
- (4-amino-2,6-dichloro-phenyl)-(4,5-dihydro-1H-imidazol-2-yl)amine hydrochloride
- Iopidine UD
- 2-(4-Amino-2,6-dichloroanilino)-2-imidazoline hydrochloride, Apraclonidine hydrochloride
- APRACLONIDINE HYDROCHLORIDE
- p-Aminoclonidine Monohydrochloride
- AL 02145
- 2,6-Dichloro-N1-(4,5-dihydro-1H-imidazol-2-yl)-1,4-benzenediamine Hydrochloride
- P-AMINOCLONIDINE HYDROCHLORIDE
- 2-[(4-AMINO-2,6-DICHLOROPHENYL)IMINO]IMIDAZOLIDINE MONOHYDROCHLORIDE
- 2-[4-AMINO-2,6-DICHLOROANILINO]-2-IMIDAZOLINE HYDROCHLORIDE
- 2,6-dichloro-n(sup1)-(4,5-dihydro-1h-imidazol-2-yl)-1,4-benzenediaminemonoh
- 2,6-dichloro-n(sup1)-(2-imidazolidinylidene)-1,4-benzenediaminehydrochlorid
- 2-(4-amino-2,6-dichlorophenylimino)imidazolidinehydrochloride