TMRM
|
|
- CAS号:
- 115532-49-5
- 英文名:
- TMRM
- 英文别名:
- TMRM.ClO4;6-(dimethylamino)-9-(2-methoxycarbonylphenyl)xanthen-3-ylidene]-dimethylazanium
- 中文名:
- TMRM
- 中文别名:
- 四甲基罗丹明甲酯(TMRM)
- CBNumber:
- CB54694918
- 分子式:
- C25H25N2O3
- 分子量:
- 401.49
- MOL File:
- 115532-49-5.mol
|
|
|
TMRM性质、用途与生产工艺
TMRM 是一种细胞渗透性阳离子亲脂性红色荧光染料 (λex=530 nm, λem=592 nm)。
TMRM is a fluorescent probe (excitation, 530±21 nm; emission, 592±22 nm). The fluorescence signal in the presence of safranin or TMRM shows a slight decrease after the addition of glutamate, indicative of increased polarization of the mitochondrial inner membrane. In the presence of TMRM (2 μM) the coupled respiration with Complex I substrates or upon the addition of Complex II substrate is decreased by 27%. Exposure of hippocampal cultures to low concentrations of TMRM (50 to 500 nM) for 1 to 3 hours results in selective staining of mitochondria in both neurons and the underlying glial cells. Exposure of hippocampal cultures to high concentrations of TMRM (1 to 25 µM) stains mitochondria selectively and quickly, reaching a plateau after 5 to 10 min. Low concentrations of TMRM (50 to 200 nM) do not induce apoptosis, whereas higher concentrations (0.5 and 2.5 µM) enhance apoptosis (K
D
= 500 nM).
TMRM
上下游产品信息
上游原料
下游产品
115532-49-5, TMRM 相关搜索:
- 药靶配体
- 荧光染料
- C25H25N2O3
- 四甲基罗丹明甲酯(TMRM)
- 115532-49-5
- 6-(dimethylamino)-9-(2-methoxycarbonylphenyl)xanthen-3-ylidene]-dimethylazanium
- TMRM.ClO4