MM 07
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- CAS号:
- 1876450-21-3
- 英文名:
- MM 07
- 英文别名:
- MM 07;MM 07 TFA;CRPRLCHKGPMPF(Modification: Disulfide bridge: 1-6)
- 中文名:
- MM 07
- 中文别名:
- MM 07 TFA;激动剂多肽MM 07;APELIN受体多肽;MM 07 三氟乙酸盐
- CBNumber:
- CB54797084
- 分子式:
- C67H106N22O14S3
- 分子量:
- 1539.91
- MOL File:
- 1876450-21-3.mol
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MM 07化学性质
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密度:
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1.52±0.1 g/cm3(Predicted)
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储存条件:
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Store at -20° C
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酸度系数(pKa):
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3.56±0.10(Predicted)
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形态:
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Solid
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颜色:
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White to off-white
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水溶解性:
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Souble in water
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MM 07性质、用途与生产工艺
MM 07 是一种有偏倚性的 apelin 受体 (apelin receptor) 激动剂，在 CHO-K 细胞中的 KD 值为 300 nM，在人心脏中的 KD 值为 172 nM。
KD: 300 nM (apelin receptor in CHO-K1 cells), 172 nM (apelin receptor in human heart).
MM 07 competes with nanomolar affinities for binding of [Glp
65
,Nle
75
,Tyr
77
] [
125
I]apelin-13 to human apelin receptors in CHO-K1 cells (K
D
, 300 nM) and human heart (K
D
, 172 nM, n=3).
MM 07 causes a dose-dependent increase in cardiac output, and although there is a decrease in vascular resistance, this is without corresponding effects on BP. Administration of SNAP produces a profound fall in BP in both [Pyr
1
]apelin-13 and MM 07-treated groups; however, although cardiac output is significantly increased in response to SNAP in the MM 07 group, it is significantly reduced in the [Pyr
1
]apelin-13 group. Neither peptide causes a significant change in heart rate, respiratory rate, or temperature. Both [Pyr
1
]apelin 13 and MM 07 increases peak velocity above basal levels.
MM 07
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| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
|---|
| 2024/04/30 | HY-108003 | 1876450-21-3
MM 07 | 1876450-21-3 | 1mg | 640元 |
| 2024/04/30 | HY-108003 | 1876450-21-3
MM 07 | 1876450-21-3 | 5mg | 1600元 |
1876450-21-3, MM 07 相关搜索:
- 药靶配体
- 目录肽
- MM 07 TFA
- MM 07 三氟乙酸盐
- 激动剂多肽MM 07
- APELIN受体多肽
- 1876450-21-3
- MM 07 TFA
- CRPRLCHKGPMPF(Modification: Disulfide bridge: 1-6)
- MM 07