U-63557A
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- CAS号:
- 85666-17-7
- 英文名:
- U-63557A
- 英文别名:
- U-63557A;furegralate sodium;SODIUM FUREGRELATE;FUREGRELATE SODIUM;FUREGRELATE SODIUM SALT;Furegrelate Sodium (U-63557A);Sodium 5-(3-pyridinylmethyl)-2-benzofurancarboxylate;5-(3'-Pyridinylmethyl)benzofuran-2-carboxylate sodium;sodium:5-(pyridin-3-ylmethyl)-1-benzofuran-2-carboxylate;5-(3-Pyridylmethyl)benzofuran-2-carboxylic acid sodium salt
- 中文名:
- U-63557A
- 中文别名:
- 化合物 T11339;化合物FUREGRELATE SODIUM
- CBNumber:
- CB5484371
- 分子式:
- C15H12NNaO3
- 分子量:
- 277.25
- MOL File:
- 85666-17-7.mol
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U-63557A化学性质
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储存条件:
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−20°C
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溶解度:
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DMF: >25 mg/ml; DMSO: >21 mg/ml; Ethanol: >14.5 mg/ml; PBS pH 7.2: >16.5 mg/ml
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形态:
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White to off-white crystalline solid.
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颜色:
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White to light yellow
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水溶解性:
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Soluble in water at approximately 15mg/ml
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U-63557A性质、用途与生产工艺
Furegrelate Sodium (U-63557A) 是一种有效的、口服的、选择性的血栓素合酶 (thromboxane synthase) 抑制剂。Furegrelate Sodium 抑制人血小板微粒体血栓素 A2 (TxA2) 合酶，其 IC50 为 15 nM。Furegrelate Sodium 正在开发作为抗血小板药物。
Furegrelate Sodium (U-63557A) (1-5 mg/kg; Oral) prevents blockage of the coronary artery.
Furegrelate Sodium (0.1-5 mg/kg; i.v.) prevents the blockage of stenosed coronary arteries caused platelet aggregation.
Furegrelate Sodium blunts the development of hypoxia-induced pulmonary arterial hypertension (PAH) in an established neonatal piglet model primarily by preserving the structural integrity of the pulmonary vasculature.
Furegrelate also is orally available, has a long half-life of 4.2–5.8 hours in adult humans (compared to several other therapies for PAH including nitric oxide and prostacyclin analogs), and reportedly is highly specific for its target enzyme.
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Animal Model:
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Mongrel dogs (19-30 kg)
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Dosage:
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1-5 mg/kg
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Administration:
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Oral (via a gastric tube)
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Result:
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Prevented blockage of the coronary artery.
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U-63557A
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下游产品
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
|---|
| 2024/04/30 | HY-106080A | U-63557A
Furegrelate sodium | 85666-17-7 | 5mg | 600元 |
| 2024/04/30 | HY-106080A | U-63557A
Furegrelate sodium | 85666-17-7 | 10 mM * 1 mLin DMSO | 660元 |
85666-17-7, U-63557A 相关搜索:
- C15H10NNaO3
- C15H10NO3Na
- 化合物FUREGRELATE SODIUM
- 化合物 T11339
- 85666-17-7
- arteries,hypertension,available,Furegrelate,inhibit,orally,antiplatelet,platelet,arterial,human,stenosed,Inhibitor,pulmonary,Furegrelate sodium,coronary
- sodium:5-(pyridin-3-ylmethyl)-1-benzofuran-2-carboxylate
- Furegrelate Sodium (U-63557A)
- Sodium 5-(3-pyridinylmethyl)-2-benzofurancarboxylate
- 5-(3'-Pyridinylmethyl)benzofuran-2-carboxylate sodium
- 2-Benzofurancarboxylic acid, 5-(3-pyridinylmethyl)-, sodium salt
- 5-(3-Pyridylmethyl)benzofuran-2-carboxylic acid sodium salt
- 5-(3-Pyridinylmethyl)benzofurancarboxylic acid sodium-potassium salt
- furegralate sodium
- 5-[3,PYRIDINYLMETHYL]BENZO-FURAN-CARBOXYLIC ACID SODIUM SALT
- 5-(3-PYRIDINYLMETHYL)-2-BENZOFURANCARBOXYLIC ACID, SODIUM SALT
- FUREGRELATE SODIUM SALT
- FUREGRELATE SODIUM
- U-63557A
- SODIUM FUREGRELATE