网站主页 >> CAS数据库列表 >> 1-(1-Methylethyl)-3-(2-phenylethynyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine
1-(1-Methylethyl)-3-(2-phenylethynyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine
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- CAS号:
- 1357349-91-7
- 英文名:
- 1-(1-Methylethyl)-3-(2-phenylethynyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine
- 英文别名:
- SPP 86;SPP86 >=98% (HPLC);Inhibitor,inhibit,SPP-86,SPP 86,SPP86,RET;1-Isopropyl-3-(phenylethynyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine;1-(1-Methylethyl)-3-(2-phenylethynyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine;1H-Pyrazolo[3,4-d]pyrimidin-4-amine, 1-(1-methylethyl)-3-(2-phenylethynyl)-
- 中文名:
- 1-(1-Methylethyl)-3-(2-phenylethynyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine
- 中文别名:
- 化合物SPP-86;SPP 86,RET抑制剂;1-异丙基-3-(苯基乙炔基)-1H-吡唑并[3,4-D]嘧啶-4-胺
- CBNumber:
- CB54902611
- 分子式:
- C16H15N5
- 分子量:
- 277.32
- MOL File:
- 1357349-91-7.mol
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1-(1-Methylethyl)-3-(2-phenylethynyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine化学性质
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沸点:
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495.3±40.0 °C(Predicted)
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密度:
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1.23±0.1 g/cm3(Predicted)
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储存条件:
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Store at -20°C
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溶解度:
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Soluble in DMSO
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酸度系数(pKa):
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3.95±0.30(Predicted)
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形态:
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Solid
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颜色:
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Off-white to light yellow
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1-(1-Methylethyl)-3-(2-phenylethynyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine性质、用途与生产工艺
SPP-86 是一种选择性的 RET 酪氨酸激酶的有效抑制剂,其 IC50 值为 8 nM。SPP-86 抑制 MCF7 细胞中 RET 诱导激活的 PI3K/Akt 和 MAPK 信号通路,也能抑制 RET 诱导的 ERα 磷酸化。
SPP86 (0-10 μM) inhibits MAPK signaling and proliferation in RET/PTC1 expressing TPC1 but not 8505C or C643 cells.
SPP86 (0-10 μM) inhibits RET- induced phosphatidylinositide 3-kinases (PI3K)/Akt and MAPK signaling and estrogen receptorα (ERα) phosphorylation in MCF7 cells.
Western Blot Analysis
Cell Line:
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Thyroid cancer derived cell lines expressing the RET/PTC1 rearrangement (TPC1), BRAF
V600E
(8505C) or RAS
G13R
(C643) mutations.
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Concentration:
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0-10 μM.
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Incubation Time:
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90 min.
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Result:
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Inhibited RET- induced ERK1/2 phosphorylation in thyroid cancer cell lines.
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Western Blot Analysis
Cell Line:
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MCF7 cells (human breast cancer).
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Concentration:
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0-10 μM.
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Incubation Time:
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30 min.
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Result:
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Inhibited RET- induced ERα phosphorylation and proliferation in MCF7 cells.
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1-(1-Methylethyl)-3-(2-phenylethynyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine
上下游产品信息
上游原料
下游产品
更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
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2024/04/30 | HY-110193 | 1-(1-Methylethyl)-3-(2-phenylethynyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine SPP-86 | 1357349-91-7 | 1mg | 480元 |
2024/04/30 | HY-110193 | 1-(1-Methylethyl)-3-(2-phenylethynyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine SPP-86 | 1357349-91-7 | 5mg | 1200元 |
1-(1-Methylethyl)-3-(2-phenylethynyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine
生产厂家
1357349-91-7, 1-(1-Methylethyl)-3-(2-phenylethynyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine 相关搜索:
- 酶
- 1-异丙基-3-(苯基乙炔基)-1H-吡唑并[3,4-D]嘧啶-4-胺
- SPP 86,RET抑制剂
- 化合物SPP-86
- 1357349-91-7
- 1-Isopropyl-3-(phenylethynyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine
- Inhibitor,inhibit,SPP-86,SPP 86,SPP86,RET
- SPP86 >=98% (HPLC)
- 1H-Pyrazolo[3,4-d]pyrimidin-4-amine, 1-(1-methylethyl)-3-(2-phenylethynyl)-
- SPP 86
- 1-(1-Methylethyl)-3-(2-phenylethynyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine