2-庚基-4-羟基喹啉-N-氧化物
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- CAS号:
- 341-88-8
- 英文名:
- 2-HEPTYL-4-HYDROXYQUINOLINE N-OXIDE
- 英文别名:
- hqno;kf8940;C04284;Pyo II;Antibiotic KF-8940;2-heptyl-4-quinolino1-oxide;NZPACTGCRWDXCJ-UHFFFAOYSA-N;2-Heptylquinolin-4-ol 1-oxide;2-Heptyl-4-quinolinol 1-oxide;4-Quinolinol, 2-heptyl-, 1-oxide
- 中文名:
- 2-庚基-4-羟基喹啉-N-氧化物
- 中文别名:
- 2-庚基-4-羟基喹啉1-氧化物;2-N-庚基-4-羟基喹啉N-氧化物
- CBNumber:
- CB5503571
- 分子式:
- C16H21NO2
- 分子量:
- 259.34
- MOL File:
- 341-88-8.mol
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2-庚基-4-羟基喹啉-N-氧化物化学性质
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熔点:
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156-157°
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沸点:
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445.8±37.0 °C(Predicted)
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密度:
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1.09±0.1 g/cm3(Predicted)
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储存条件:
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Sealed in dry,2-8°C
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溶解度:
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Soluble in DMSO (up to 8 mg/ml with warming), or in Ethanol (up to 13 mg/ml with warming).
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酸度系数(pKa):
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1.07±0.40(Predicted)
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形态:
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White to off-white crystalline solid.
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颜色:
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White
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稳定性:
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Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 1 month.
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2-庚基-4-羟基喹啉-N-氧化物性质、用途与生产工艺
HQNO (2-heptyl-4-hydroxyquinoline-N-oxide)是一种由 P. aeruginosa 分泌的天然喹诺酮。HQNO 也是一种 electron transport chain 的有效抑制剂,其对呼吸链的泛醇-亚铁色素c氧化还原酶区段(Complex III)的Kd值为64 nM。在50 μM menadione存在下,HQNO 还是细菌和线粒体的 Type II NADH : quinone oxidoreductase (NDH-2) 的抑制剂,在50 μM menadione存在的条件下,其IC50值为7.3 μM。
Target | Value |
Complex III
(Cell-free assay)
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64 nM(Kd)
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NDH-2
(Cell-free assay)
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7.3 μM
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HQNO is a potent inhibitor of mitochondrial type II NADH:quinone oxidoreductase (NDH-2) in many species, including
Yarrowia lipolytica
,
S. cerevisiae
,
Gluconobacter oxydans
,
T. gondii
,
P. falciparum
, and
S. aureus
. HQNO targets the Q-site of NDH-2.
HQNO concentrations are varied from 0 to 100 μM and 0 to 300 μM for wild-type (WT) and I379E
C. thermarum
NDH-2 variant, respectively to determine IC
50
values. WT NDH-2 has an IC
50
value of 10.5±1.3 μM HQNO in the presence of 400 μM Menadione (MD). In the presence of 50 μM MD, the IC
50
value for HQNO decreases slightly to 7.3±1.2 μM and near complete inhibition (~15% residual activity) is observed with >50 μM HQNO. At 50 μM MD, HQNO inhibition is observed with an IC
50
value of 54.3±1.2 μM.
2-庚基-4-羟基喹啉-N-氧化物
上下游产品信息
上游原料
下游产品
更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
---|
2024/04/30 | HY-130055 | HQNO | | 5 mg | 625元 |
2024/04/30 | S8970 | 2-庚基-4-羟基喹啉-N-氧化物 HQNO | 341-88-8 | 5mg | 972.52元 |
341-88-8, 2-庚基-4-羟基喹啉-N-氧化物 相关搜索:
- 2-N-庚基-4-羟基喹啉N-氧化物
- 2-庚基-4-羟基喹啉1-氧化物
- 341-88-8
- electron,transport,Mitochondrial Metabolism,complex III,NDH-2,Inhibitor,HQNO,mitochondrial,chain,inhibit
- hqno
- 2-heptyl-4-hydroxyquinolin-1-ium-1-olate
- 4-Quinolinol, 2-heptyl-, 1-oxide
- 2-Heptyl-4-quinolinol 1-oxide
- NZPACTGCRWDXCJ-UHFFFAOYSA-N
- C04284
- Pyo II
- Antibiotic KF-8940
- 2-Heptylquinolin-4-ol 1-oxide
- kf8940
- 2-heptyl-4-quinolino1-oxide
- 2-(n-heptyl)-4-hydroxyquinolinen-oxide