Mps1-IN-1 dihydrochloride
|
|
- CAS号:
- 1883548-93-3
- 英文名:
- Mps1-IN-1 dihydrochloride
- 英文别名:
- Mps1-IN-1 dihydrochloride
- 中文名:
- Mps1-IN-1 dihydrochloride
- 中文别名:
- CBNumber:
- CB55304045
- 分子式:
- C28H34ClN5O4S
- 分子量:
- 572.12
- MOL File:
- 1883548-93-3.mol
|
|
|
Mps1-IN-1 dihydrochloride化学性质
-
储存条件:
-
Store at -20°C
-
|
-
溶解度:
-
Soluble in DMSO
-
|
Mps1-IN-1 dihydrochloride性质、用途与生产工艺
Mps1-IN-1 dihydrochloride 是一种有效的,选择性的,ATP 竞争性的 Mps1 抑制剂,IC50 和 Kd 值分别为 367 nM 和 27 nM。
Mps1
27 nM (Kd)
|
ALK
21 nM (Kd)
|
LTK
29 nM (Kd)
|
PYK2
280 nM (Kd)
|
FAK
440 nM (IC30)
|
IGF1R
750 nM (Kd)
|
INSR
470 nM (Kd)
|
CLK1
1900 nM (Kd)
|
ERK2
2900 nM (Kd)
|
INSRR
1200 nM (Kd)
|
TNK1
2600 nM (Kd)
|
TNK2
3100 nM (Kd)
|
GAK
1100 nM (Kd)
|
Mps1
367 nM (IC
50
)
|
Mps1-IN-1 dihydrochloride is a potent, selective and ATP-competitive Mps1 kinase inhibitor, with an IC
50
and a K
d
of 367 nM and 27 nM. Mps1-IN-1 dihydrochloride also has high affinity for ALK, and LTK, with K
d
s of 21 and 39 nM, respectively, but shows little or no inhibition on other 352 member kinases. Mps1-IN-1 dihydrochloride (5, 10 μM) induces bypass of a checkpoint-mediated mitotic arrest in U2OS cells. Mps1-IN-1 disrupts recruitment of Mad2 to kinetochores, and reduces the phosphorylation status of Aurora B at threonine-232 (Thr232). Mps1-IN-1 dihydrochloride (10 µM) shows no effect on centrosome duplication. In addition, Mps1-IN-1 dihydrochloride (5-10 µM) suppresses the proliferative capacity of HCT116.
Mps1-IN-1 dihydrochloride
上下游产品信息
上游原料
下游产品
更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
---|
2024/08/19 | HY-110347 | Mps1-IN-1 dihydrochloride | | 5 mg | 5239元 |
2024/08/19 | HY-110347 | Mps1-IN-1 dihydrochloride | | 10 mg | 8381元 |
Mps1-IN-1 dihydrochloride
生产厂家
1883548-93-3, Mps1-IN-1 dihydrochloride 相关搜索:
- 1883548-93-3
- Mps1-IN-1 dihydrochloride