OXFBD04
|
|
- CAS号:
- 2231747-03-6
- 英文名:
- OXFBD04
- 英文别名:
- OXFBD04;OXFBD04,OXFBD-04;3-(3,5-Dimethyl-4-isoxazolyl)-5-[hydroxy(3-pyridyl)methyl]phenol;3-Pyridinemethanol, α-[3-(3,5-dimethyl-4-isoxazolyl)-5-hydroxyphenyl]-
- 中文名:
- OXFBD04
- 中文别名:
- 化合物OXFBD04;化合物 T12338;3-(3,5-二甲基-4-异噁唑基)-5-[羟基(3-吡啶基)甲基]苯酚
- CBNumber:
- CB55559119
- 分子式:
- C17H16N2O3
- 分子量:
- 296.33
- MOL File:
- 2231747-03-6.mol
|
|
|
OXFBD04化学性质
-
沸点:
-
550.4±50.0 °C(Predicted)
-
|
-
密度:
-
1.273±0.06 g/cm3(Predicted)
-
|
-
储存条件:
-
Store at -20°C
-
|
-
溶解度:
-
DMSO: ≥ 250 mg/mL (843.68 mM)
-
|
-
形态:
-
Solid
-
|
-
酸度系数(pKa):
-
9.09±0.10(Predicted)
-
|
-
颜色:
-
White to off-white
-
|
OXFBD04性质、用途与生产工艺
OXFBD04 是一种有效的选择性 BRD4 抑制剂,IC50 为 166 nM。OXFBD04 是一种有效的 BET 溴结构域配体,对 CREBBP 溴结构域具有额外的适度亲和力。OXFBD04 具有抗癌活性。
OXFBD04 (0.01-100 μM; 48 hours) inhibits cancer cell lines growth.
OXFBD04 (10 µM; for 10, 24, or 48 hours) induces MYC suppression in MCF7 breast cancer cells.
Cell Viability Assay
Cell Line:
|
A498 (renal), HT-29 (colon), and MCF7 (breast) cancer cell lines
|
Concentration:
|
0.01, 0.1, 1, 10, 100 μM
|
Incubation Time:
|
48 hours
|
Result:
|
Inhibited cancer cell lines growth.
|
OXFBD04 has optimised physicochemical properties (LE=0.43; LLE=5.74; SFI=5.96), and good metabolic stability (t
1/2
=388 min). OXFBD04 has CL
int
of 3.57 µL/min/mg.
OXFBD04
上下游产品信息
上游原料
下游产品
更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
---|
2024/08/19 | HY-135236 | OXFBD04 | | 1 mg | 1150元 |
2024/08/19 | HY-135236 | OXFBD04 OXFBD04 | 2231747-03-6 | 5mg | 2900元 |
2231747-03-6, OXFBD04 相关搜索:
- 对照品
- 3-(3,5-二甲基-4-异噁唑基)-5-[羟基(3-吡啶基)甲基]苯酚
- 化合物OXFBD04
- 化合物 T12338
- 2231747-03-6
- 3-(3,5-Dimethyl-4-isoxazolyl)-5-[hydroxy(3-pyridyl)methyl]phenol
- 3-Pyridinemethanol, α-[3-(3,5-dimethyl-4-isoxazolyl)-5-hydroxyphenyl]-
- OXFBD04,OXFBD-04
- OXFBD04