RAT ANTI C-MYC
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- CAS号:
- 英文名:
- RAT ANTI C-MYC
- 英文别名:
- RAT ANTI C-MYC
- 中文名:
- RAT ANTI C-MYC
- 中文别名:
- CBNumber:
- CB55688877
- 分子式:
- 分子量:
- 0
- MOL File:
- Mol file
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RAT ANTI C-MYC性质、用途与生产工艺
大鼠单克隆抗体[JAC6] to c-Myc
Rat
与反应: Human
Rat anti c-myc antibody, clone JAC6 (MCA 1929) used for the detection of c-myc tagged APP by immunofluorescence.
Image caption:
APP processing deficient mutants show stronger synaptogenic activity than APPwt. The synaptogenic activity of APP was analyzed in a co-culture assay. HEK293 cells were transiently transfected with APPwt and seeded 24 h later on primary cortical neurons (DIV7). The cells were fxed after 24 h (neurons DIV 8) and analyzed via immunocytochemistry. (A) Cells were stained with TAU1 as axonal marker, Synaptophysin as presynaptic marker and antibody c-myc for APP.
From: Stahl R, Schilling S, Soba P, et al.
Shedding of APP limis its synaptogenic activity and cell adhesion properties.
Front Cell Neurosci. 2014:8:410.
doi:10.3389/fncel.2014.00410
This image is from an open access article distributed under terms of a Creative Commons Attribution License.
Synthetic peptide corresponding to Human c-Myc aa 408-439.
Sequence: AEEQKLISEEDLLRKRREQLKHKLEQLRNSCA
C-myc基因是myc基因家族的重要成员之一，c-myc基因既是一种可易位基因，又是一种多种物质调节的可调节基因，也是一种可使细胞无限增殖，获永生化功能，促进细胞分裂的基因，myc基因参于细胞凋零，c-myc基因与多种肿瘤发生发展有关。
C-myc基因的产物为62KD的磷酸化蛋白P62c-mgc，是由C-myc基因的外显子2和3共同编码的由439个氨基酸组成的蛋白质，定位细胞核内，为核蛋白，依C-one编码产物，功能分类，C-myc癌基因属核蛋白基因，具有转化细胞的能力，并具有与染色体、DNA结合的特性，在调节细胞生长、分化及恶性转化中发挥作用。
RAT ANTI C-MYC用于基于c-Myc/CLIC4通路探究脂多糖致大鼠海马损伤的致病机制研究。
RAT ANTI C-MYC
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