GSK-3 β inhibitor 2
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- CAS号:
- 1702428-31-6
- 英文名:
- GSK-3 β inhibitor 2
- 英文别名:
- GSK-3β inhibitor 2;GSK-3 β inhibitor 2;2-(2-(Cyclopropanecarboxamido)pyridin-4-yl)-4-methoxythiazole-5-carboxamide;5-Thiazolecarboxamide,2-[2-[(cyclopropylcarbonyl)amino]-4-pyridinyl]-4-methoxy-
- 中文名:
- GSK-3 β inhibitor 2
- 中文别名:
- 化合物 T11471;GSK-3Β 抑制剂 2;2-(2-(环丙烷甲酰胺基)吡啶-4-基)-4-甲氧基噻唑-5-甲酰胺
- CBNumber:
- CB57247236
- 分子式:
- C14H14N4O3S
- 分子量:
- 318.35
- MOL File:
- 1702428-31-6.mol
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GSK-3 β inhibitor 2化学性质
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密度:
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1.475±0.06 g/cm3(Predicted)
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酸度系数(pKa):
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13.08±0.20(Predicted)
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形态:
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Solid
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颜色:
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Light yellow to yellow
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GSK-3 β inhibitor 2性质、用途与生产工艺
GSK-3β inhibitor 2 (Compound 3) 是一种有效,选择性和口服活性的 GSK-3β 抑制剂,IC50 为 1.1 nM。GSK-3β inhibitor 2 可以穿越血脑屏障。GSK-3β inhibitor 2 有用于阿尔茨海默氏病的潜力。
The pyridine carboxamide of GSK-3β inhibitor 2 (Compound 3) makes hydrogen bonds with the hinge V135 backbone amide, and the carbonyl oxygen of the thiazolyl primary amide formed a critical hydrogen bond with K85. The quality of the electron density for the methyl group of the methoxy moiety in GSK-3β inhibitor 2 does not allow its unambiguous placement in the model, but a small molecule crystal structure of GSK-3β inhibitor 2 determined by single crystal X-ray diffraction method confirmed the intramolecular hydrogen bonding between the methoxy -O- and the amide N-H in GSK-3β inhibitor 2.
The elevation of hyperphosphorylated Tau (pTau) is mimicked in LaFerla 3xTg-C57BL6 mice, and accordingly, these mice are used as an in vivo model of Alzheimer’s disease. GSK-3β inhibitor 2 (Compound 3) shows a significant reduction in pTau396 when administered orally at 30 mg/kg as a nanosuspension to LaFerla 3xTg-C57BL6 male mice. GSK-3β inhibitor 2 shows only modest brain exposure (B/P = 0.26) as determined as a single time point.
GSK-3 β inhibitor 2
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更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
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2024/04/30 | HY-130795 | GSK-3 β inhibitor 2 GSK-3β inhibitor 2 | 1702428-31-6 | 5mg | 1750元 |
2024/04/30 | HY-130795 | GSK-3 β inhibitor 2 GSK-3β inhibitor 2 | 1702428-31-6 | 10mg | 2800元 |
1702428-31-6, GSK-3 β inhibitor 2 相关搜索:
- 2-(2-(环丙烷甲酰胺基)吡啶-4-基)-4-甲氧基噻唑-5-甲酰胺
- GSK-3Β 抑制剂 2
- 化合物 T11471
- 1702428-31-6
- 2-(2-(Cyclopropanecarboxamido)pyridin-4-yl)-4-methoxythiazole-5-carboxamide
- 5-Thiazolecarboxamide,2-[2-[(cyclopropylcarbonyl)amino]-4-pyridinyl]-4-methoxy-
- GSK-3β inhibitor 2
- GSK-3 β inhibitor 2