2426685-25-6
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- CAS号:
- 2426685-25-6
- 英文名:
- L-Lysine, L-serylglycyl-L-glutaminyl-L-tyrosyl-L-alanyl-L-seryl-L-tyrosyl-L-histidyl-L-cysteinyl-L-tryptophyl-L-cysteinyl-L-tryptophyl-L-arginyl-L-α-aspartyl-L-prolylglycyl-L-arginyl-L-serylglycylglycyl-L-seryl-
- 英文别名:
- L-Lysine, L-serylglycyl-L-glutaminyl-L-tyrosyl-L-alanyl-L-seryl-L-tyrosyl-L-histidyl-L-cysteinyl-L-tryptophyl-L-cysteinyl-L-tryptophyl-L-arginyl-L-α-aspartyl-L-prolylglycyl-L-arginyl-L-serylglycylglycyl-L-seryl-
- 中文名:
- 2426685-25-6
- 中文别名:
- 有效抑制剂多肽TPP-1
- CBNumber:
- CB58378302
- 分子式:
- C107H150N34O32S2
- 分子量:
- 2488.7
- MOL File:
- 2426685-25-6.mol
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2426685-25-6化学性质
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密度:
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1.60±0.1 g/cm3(Predicted)
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储存条件:
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Store at -20°C
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形态:
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Solid
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颜色:
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White to off-white
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2426685-25-6性质、用途与生产工艺
TPP-1 是 PD-1/PD-L1 相互作用的有效抑制剂。TPP-1 与 PD-L1 特异性高亲和力结合 (KD=95 nM)。动物模型中，TPP-1 通过再激活 T 细胞功能抑制肿瘤生长。
TPP-1 binds to PD-L1 with high affinity and blocks PD-1/PD-L1 interaction. The K
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value of PD-L1 with TPP-1 peptide is about 95 nmol/L (around five times less than that with PD-1), The binding site of TPP-1 to PD-L1 is close to the interactive site of PD-1 and PD-L1.TPP-1 (4 μM) reactivates T-cell functions, it induces IFNγ release significantly higher than control and SPP-1, and the TPP-1 group shows similar outcomes for cell proliferation.
TPP-1 (subcutaneous injection; 4 mg/kg; every other day eight times; 32 days) inhibits tumor growth (compared with SPP-1 and control). The growth rate in TPP-1-treated mice is 56%. And when administered in the absence of T cells (control group), TPP-1 has no effect on the growth of the H460-luc tumors.
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Animal Model:
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5 to 6-week-old female Balb/c nude mice injected with H460 cells transfected with the plvx-puro/luciferase lentiviral vector
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Dosage:
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4 mg/kg
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Administration:
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Subcutaneous injection; 4 mg/kg; every other day eight times; 32days
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Result:
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Inhibited the tumor growth in a tumor xenograft model via reactivating T-cell function.
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2426685-25-6
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2426685-25-6, 2426685-25-6 相关搜索:
- 目录肽
- C107H150N34O32S2
- 有效抑制剂多肽TPP-1
- 2426685-25-6
- L-Lysine, L-serylglycyl-L-glutaminyl-L-tyrosyl-L-alanyl-L-seryl-L-tyrosyl-L-histidyl-L-cysteinyl-L-tryptophyl-L-cysteinyl-L-tryptophyl-L-arginyl-L-α-aspartyl-L-prolylglycyl-L-arginyl-L-serylglycylglycyl-L-seryl-