盐酸维那卡兰
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- CAS号:
- 748810-28-8
- 英文名:
- VERNAKALANT HYDROCHLORIDE
- 英文别名:
- D06665;Vernakalant HCl;RSD1235 hydrochloride;RSD 1235 hydrochloride;RSD-1235 hydrochloride;Mepivacaine Impurity 8;VERNAKALANT HYDROCHLORIDE;Vernakalant hydrochloride (usan);Vernakalant ((3R,1'R,2'R)-Isomer) HCl;Vernakalant ((3R,1'R,2'R)-Isomer) HCl
- 中文名:
- 盐酸维那卡兰
- 中文别名:
- 盐酸维纳卡兰;盐酸弗纳卡兰;盐酸维那卡兰;化合物 T17227;(R)-1-((1R,2R)-2-(3,4-二甲氧基苯乙氧基)环己基)吡咯烷-3-醇盐酸盐
- CBNumber:
- CB61011678
- 分子式:
- C20H32ClNO4
- 分子量:
- 385.93
- MOL File:
- 748810-28-8.mol
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盐酸维那卡兰化学性质
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熔点:
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151-153oC
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储存条件:
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Hygroscopic, Refrigerator, under inert atmosphere
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溶解度:
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DMSO (Slightly), Methanol (Slightly)
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形态:
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Solid
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颜色:
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White to Pale Yellow
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盐酸维那卡兰性质、用途与生产工艺
Vernakalant hydrochloride 是一种混合电压和频率依赖性的 Na+ 和 K+ 通道阻断剂。Vernakalant 抑制 Kv1.5 channelwt，Kv1.5 channelI508F，Kv1.5 channelT479A，IC50 分别为 13.35±0.93 μM。
IC50: 13.35±0.93 μM (Kv1.5 channel
wt
), 0.61±0.03 μM (
I508F
), 1.63±0.09 μM (Kv1.5 channel
T479A
)
Block of Kv1.5 by Vernakalant Hydrochloride is mediated after channel activation, because Vernakalant causes a relatively rapid onset of block of channel current upon depolarization but little evidence of resting or “tonic” block of the channel. In the presence of 10 μM Vernakalant, rapid block is apparent after channel opening, and a steady-state current level is rapidly reached. The most important effect is the reduction in potency for Vernakalant centered at I502A, which had an IC
50
of 329±19 μM (n=4-10), compared with a control IC
50
of 13.4±0.9 μM (n=5-23), which is a 25-fold decrease in potency. V505A, I508A, T480A, and C500A showed lesser reductions in potency on Kv1.5, of between 3- and 4-fold. I508Y in our experiments increased the IC
50
for Vernakalant on Kv1.5 to 24.7 μM, again similar to the reported value for hERG.
盐酸维那卡兰
上下游产品信息
上游原料
下游产品
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
|---|
| 2024/08/19 | HY-14183 | 盐酸维那卡兰
Vernakalant Hydrochloride | 748810-28-8 | 2mg | 950元 |
| 2024/08/19 | HY-14183 | 盐酸维那卡兰
Vernakalant Hydrochloride | 748810-28-8 | 5mg | 1800元 |
748810-28-8, 盐酸维那卡兰 相关搜索:
- 高端化学
- C20H32ClNO4
- C20H31NO4HCl
- (R)-1-((1R,2R)-2-(3,4-二甲氧基苯乙氧基)环己基)吡咯烷-3-醇盐酸盐
- 化合物 T17227
- 盐酸维纳卡兰
- 盐酸弗纳卡兰
- 盐酸维那卡兰
- 748810-28-8
- Vernakalant ((3R,1'R,2'R)-Isomer) HCl
- Mepivacaine Impurity 8
- (R)-1-((1R,2R)-2-(3,4-dimethoxyphenethoxy)cyclohexyl)pyrrolidin-3-ol hydrochloride
- (3R)-1-{(1R,2R)-2-[2-(3,4-Dimethoxyphenyl)ethoxy]cyclohexyl}-3-py rrolidinol hydrochloride (1:1)
- RSD1235 HYDROCHLORIDE;RSD 1235 HYDROCHLORIDE;RSD-1235 HYDROCHLORIDE
- (3R)-1-[(1R,2R)-2-[2-(3,4-Dimethoxyphenyl)ethoxy]cyclohexyl]-3-pyrrolidinol monohydrochloride
- Vernakalant hydrochloride (usan)
- D06665
- VERNAKALANT HYDROCHLORIDE
- Vernakalant HCl
- Vernakalant ((3R,1'R,2'R)-Isomer) HCl
- RSD-1235 hydrochloride
- RSD1235 hydrochloride
- RSD 1235 hydrochloride