化合物 T32535
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- CAS号:
- 209394-27-4
- 英文名:
- LADOSTIGIL
- 英文别名:
- LADOSTIGIL;Ladostigil (TV-3,326);LHXOCOHMBFOVJS-OAHLLOKOSA-N;TV-3326|||Ladostigil|||TV 3326|||TV3326|||Ladostigil free base;Carbamic acid, N-ethyl-N-methyl-, (3R)-2,3-dihydro-3-(2-propyn-1-ylamino)-1H-inden-5-yl ester
- 中文名:
- 化合物 T32535
- 中文别名:
- 化合物LADOSTIGIL
- CBNumber:
- CB61086801
- 分子式:
- C16H20N2O2
- 分子量:
- 272.34
- MOL File:
- 209394-27-4.mol
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化合物 T32535化学性质
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沸点:
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412.4±45.0 °C(Predicted)
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密度:
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1.14±0.1 g/cm3(Predicted)
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酸度系数(pKa):
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6.94±0.20(Predicted)
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化合物 T32535性质、用途与生产工艺
Ladostigil (TV-3326) 是胆碱酯酶 (cholinesterase) 和脑选择性单胺氧化酶 (MAO) 的双重抑制剂，抑制 MAO-B 和 AChE 的 IC50 值分别为 37.1 和 31.8 μM。Ladostigil 能够增加胆碱能的传递，防止 ROS 的形成或其作用，可用于抑郁症和阿尔茨海默氏病的研究。
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MAO-B
37.1 μM (IC
50
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AChE
31.8 μM (IC
50
)
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Ladostigil (1-10 µM) exerts neuroprotective activities, including a prevention of the fall of the mitochondrial membrane potential (ψ), attenuation of apoptotic cascades and an inhibition of ROS production induced by OS insults.
Ladostigil (1-10 µM) has a significant neuroprotective activity, including inhibition of caspase-3 activation, induction of Bcl-2 and reduction of Bad and Bax gene and protein expression in human neuroblastoma SK-N-SH cells.
Ladostigil (17 mg/kg; p.o. daily for 6 weeks) abolishes their hyperanxiety and depressive-like behaviour in the elevated plus maze (EPM) and forced swim tests (FST) tests in adulthood from puberty to prenatally-stressed rats.
Ladostigil (50 μmol/kg; single p.o.) restores the loss of episodic memory in the object recognition test in rats.
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Animal Model:
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Pathogen-free (SPF) Sprague-Dawley rats
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Dosage:
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17 mg/kg
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Administration:
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P.o. (added to the drinking water) daily for 6 weeks
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Result:
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Inhibited brain MAO-A and B by more than 60%.
Reduced hyperanxiety of male and female prenatally stressed (PS) rats in the EPM and depressive-like behaviour in the FST.
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化合物 T32535
上下游产品信息
上游原料
下游产品
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
|---|
| 2024/08/19 | HY-10399 | Ladostigil | | 1 mg | 2045元 |
| 2024/08/19 | HY-10399 | Ladostigil | 209394-27-4 | 5mg | 4500元 |
209394-27-4, 化合物 T32535 相关搜索:
- 209349-27-4
- 化合物LADOSTIGIL
- 209394-27-4
- TV-3326|||Ladostigil|||TV 3326|||TV3326|||Ladostigil free base
- Carbamic acid, N-ethyl-N-methyl-, (3R)-2,3-dihydro-3-(2-propyn-1-ylamino)-1H-inden-5-yl ester
- LHXOCOHMBFOVJS-OAHLLOKOSA-N
- Ladostigil (TV-3,326)
- LADOSTIGIL