网站主页 >> CAS数据库列表 >> N-[3-[4-[[4-(3,4-二氢-2-氧代-1(2H)-喹啉基)-1-哌啶基]羰基]苯氧基]丙基]乙酰胺
N-[3-[4-[[4-(3,4-二氢-2-氧代-1(2H)-喹啉基)-1-哌啶基]羰基]苯氧基]丙基]乙酰胺
|
|
- CAS号:
- 131631-89-5
- 英文名:
- OPC 21268
- 英文别名:
- CS-2724;Fuscoside;OPC 21268;OPC-21268 hydrate;OPC 21268;OPC-21268;OPC21268;Inhibitor,Vasopressin Receptor,OPC21268,Fuscoside,OPC-21268,inhibit;1-[1-[4-(3-Acetylaminopropoxy)benzoyl]-4-piperidyl]-3,4-dihydroquinolin-2(1H)-one;1-{1-[4(3-acetylaminopropoxy)benzoyl]-4-piperidyl}-3,4-dihydro-2(1H)-quinolinone hydrate;N-[3-[4-[4-(2-oxo-3,4-dihydroquinolin-1-yl)piperidine-1-carbonyl]phenoxy]propyl]acetamide;N-[3-[4-[[4-(3,4-Dihydro-2-oxo-1(2H)-quinolinyl)-1-piperidinyl]carbonyl]phenoxy]propyl]acetamide
- 中文名:
- N-[3-[4-[[4-(3,4-二氢-2-氧代-1(2H)-喹啉基)-1-哌啶基]羰基]苯氧基]丙基]乙酰胺
- 中文别名:
- 化合物OPC 21268;OPC 21268,加压素V1拮抗剂;N-[3-[4-[[4-(3,4-二氢-2-氧代-1(2H)-喹啉基)-1-哌啶基]羰基]苯氧基]丙基]乙酰胺
- CBNumber:
- CB61356814
- 分子式:
- C26H31N3O4
- 分子量:
- 449.54
- MOL File:
- 131631-89-5.mol
|
|
|
N-[3-[4-[[4-(3,4-二氢-2-氧代-1(2H)-喹啉基)-1-哌啶基]羰基]苯氧基]丙基]乙酰胺化学性质
-
沸点:
-
772.5±60.0 °C(Predicted)
-
|
-
密度:
-
1?+-.0.06 g/cm3(Predicted)
-
|
-
储存条件:
-
2-8°C
-
|
-
溶解度:
-
DMSO: ≥20mg/mL
-
|
-
酸度系数(pKa):
-
16.17±0.46(Predicted)
-
|
-
形态:
-
powder
-
|
-
颜色:
-
white to off-white
-
|
N-[3-[4-[[4-(3,4-二氢-2-氧代-1(2H)-喹啉基)-1-哌啶基]羰基]苯氧基]丙基]乙酰胺性质、用途与生产工艺
Fuscoside (OPC-21268) 是一种口服有效的非多肽类加压素受体 (vasopressin V1) 拮抗剂, IC50 值为0.4 μM。
IC50: 0.4 μM (vasopressin V1)
Ki: 0.14 μM (vasopressin V1)
The concentration of Fuscoside (OPC-21268) that displaces 50% of specific AVP binding (IC
50
) is 0.4 μM for VI receptors and 100 μM for V2 receptors. The inhibition constant (K
i
) of Fuscoside (OPC-21268) for V1 receptors (0.14 μM).
Fuscoside (OPC-21268) competitively and specifically antagonizes pressor responses to AVP
in vivo
. Oral administration of Fuscoside (OPC-21268) (10 mg/kg) inhibits the vasoconstriction induced by exogenous AVP in a dose- and time-dependent manner and the effect lasts for more than 8 hours at 30 mg/kg. Fuscoside (OPC-21268) predominantly exerts a protective effect in areas where the maximum amount of blood-brain barrier breakdown occurs, and it is effective in the treatment of cold-induced vasogenic brain edema. Fuscoside (OPC-21268) treatment at the dosages of 200 and 300 mg/kg significantly reduces brain water content in both hemispheres. Swelling of the traumatized hemispheres is also significantly reduced at 200 and 300 mg/kg dosages.
N-[3-[4-[[4-(3,4-二氢-2-氧代-1(2H)-喹啉基)-1-哌啶基]羰基]苯氧基]丙基]乙酰胺
上下游产品信息
上游原料
下游产品
更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
---|
2024/04/30 | HY-15009 | Fuscoside | | 1 mg | 377元 |
2024/04/30 | HY-15009 | N-[3-[4-[[4-(3,4-二氢-2-氧代-1(2H)-喹啉基)-1-哌啶基]羰基]苯氧基]丙基]乙酰胺 Fuscoside | 131631-89-5 | 5mg | 900元 |
N-[3-[4-[[4-(3,4-二氢-2-氧代-1(2H)-喹啉基)-1-哌啶基]羰基]苯氧基]丙基]乙酰胺
生产厂家
131631-89-5, N-[3-[4-[[4-(3,4-二氢-2-氧代-1(2H)-喹啉基)-1-哌啶基]羰基]苯氧基]丙基]乙酰胺 相关搜索:
- 合成有机化合物配体
- OPC 21268,加压素V1拮抗剂
- 化合物OPC 21268
- N-[3-[4-[[4-(3,4-二氢-2-氧代-1(2H)-喹啉基)-1-哌啶基]羰基]苯氧基]丙基]乙酰胺
- 131631-89-5
- Inhibitor,Vasopressin Receptor,OPC21268,Fuscoside,OPC-21268,inhibit
- Acetamide, N-[3-[4-[[4-(3,4-dihydro-2-oxo-1(2H)-quinolinyl)-1-piperidinyl]carbonyl]phenoxy]propyl]-
- Fuscoside
- CS-2724
- OPC 21268;OPC-21268;OPC21268
- N-[3-[4-[4-(2-oxo-3,4-dihydroquinolin-1-yl)piperidine-1-carbonyl]phenoxy]propyl]acetamide
- OPC 21268
- N-[3-[4-[[4-(3,4-Dihydro-2-oxo-1(2H)-quinolinyl)-1-piperidinyl]carbonyl]phenoxy]propyl]acetamide
- OPC-21268 hydrate
- N-[3-[4-[[4-(3,4-dihydro-2-oxo-1(2H)-quinolinyl)-1-piperidinyl]carbonyl]phenoxy]propyl]-acetamide hydrate
- 1-{1-[4(3-acetylaminopropoxy)benzoyl]-4-piperidyl}-3,4-dihydro-2(1H)-quinolinone hydrate
- 1-[1-[4-(3-Acetylaminopropoxy)benzoyl]-4-piperidyl]-3,4-dihydroquinolin-2(1H)-one