2-[[[4-(4-氟苯氧基)苯基]磺酰基]氨基] -N-羟基-2-甲基丙酰胺
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- CAS号:
- 210755-45-6
- 英文名:
- CP 471,474
- 英文别名:
- CP 471,474;PF-1626077;2-(4-(4-Fluorophenoxy)phenylsulfonamido)-N-hydroxy-2-methylpropanamide;2-[[[4-(4-Fluorophenoxy)phenyl]sulfonyl]amino]-N-hydroxy-2-methylpropanamide;Propanamide, 2-[[[4-(4-fluorophenoxy)phenyl]sulfonyl]amino]-N-hydroxy-2-methyl-
- 中文名:
- 2-[[[4-(4-氟苯氧基)苯基]磺酰基]氨基] -N-羟基-2-甲基丙酰胺
- 中文别名:
- 化合物 T22685;2-[[[4-(4-氟苯氧基)苯基]磺酰基]氨基] -N-羟基-2-甲基丙酰胺
- CBNumber:
- CB61389258
- 分子式:
- C16H17FN2O5S
- 分子量:
- 368.38
- MOL File:
- 210755-45-6.mol
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2-[[[4-(4-氟苯氧基)苯基]磺酰基]氨基] -N-羟基-2-甲基丙酰胺化学性质
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熔点:
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135-137°C (dec.)
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密度:
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1.375±0.06 g/cm3(Predicted)
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储存条件:
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room temp
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溶解度:
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DMSO: ≥20mg/mL
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酸度系数(pKa):
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9.33±0.50(Predicted)
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形态:
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powder
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颜色:
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white to off-white
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2-[[[4-(4-氟苯氧基)苯基]磺酰基]氨基] -N-羟基-2-甲基丙酰胺性质、用途与生产工艺
CP-471474 是一个口服有效的、广泛的 MMP 抑制剂，IC50 值分别为1170 nM (MMP-1)、0.7 nM (MMP-2)、16 nM (MMP-3)、13 nM (MMP-9) 和 0.9 nM (MMP-13)。
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MMP-2
0.7 nM (IC
50
)
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MMP-13
0.9 nM (IC
50
)
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MMP-9
13 nM (IC
50
)
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MMP-3
16 nM (IC
50
)
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MMP-1
1170 nM (IC
50
)
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CP-471474 plasma levels following subcutaneous injection are 2,020 ng/mL (1 h postdose) to 160 ng/mL (6 h postdose).
CP-471,474 significantly reduces both the extent and severity of inflammation at 2 months. At 4 months, a spontaneous reduction of the inflammatory response is observed in both treated and untreated animals, and consequently no difference is observed between both.
CP-471474 significantly decreases the destructive lesions mainly at 2 months and also at 4 months.
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Animal Model:
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Guinea pigs weighing 400 to 450 g (COPD).
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Dosage:
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20 mg/kg (also supplemented daily by the diet (200 mg/200 g powdered chow)).
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Administration:
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Subcutaneously (in 20% ethanol/80% polyethylene glycol), once a day during the entire course.
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Result:
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Lungs derived from smoking animals treated with the compound demonstrated a statistically significant reduction in the destructive lesions.
Showed an increase of both pro–MMP-9 and its active form (lanes 5 to 8) as compared with control animals.
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2-[[[4-(4-氟苯氧基)苯基]磺酰基]氨基] -N-羟基-2-甲基丙酰胺
上下游产品信息
上游原料
下游产品
2-[[[4-(4-氟苯氧基)苯基]磺酰基]氨基] -N-羟基-2-甲基丙酰胺
生产厂家
210755-45-6, 2-[[[4-(4-氟苯氧基)苯基]磺酰基]氨基] -N-羟基-2-甲基丙酰胺 相关搜索:
- Heterocycles
- Sulfur & Selenium Compounds
- Pharmaceuticals
- Pfizer Compounds
- Intermediates & Fine Chemicals
- Inhibitors
- Aromatics
- Amines
- 抑制剂
- C16H16FN2O5S
- 化合物 T22685
- 2-[[[4-(4-氟苯氧基)苯基]磺酰基]氨基] -N-羟基-2-甲基丙酰胺
- 210755-45-6
- Propanamide, 2-[[[4-(4-fluorophenoxy)phenyl]sulfonyl]amino]-N-hydroxy-2-methyl-
- 2-(4-(4-Fluorophenoxy)phenylsulfonamido)-N-hydroxy-2-methylpropanamide
- 2-[[[4-(4-Fluorophenoxy)phenyl]sulfonyl]amino]-N-hydroxy-2-methylpropanamide
- CP 471,474
- PF-1626077