(2S)-3-(4-hydroxyphenyl)-4-methyl-2-[4-[2-(1-piperidyl)ethoxy]phenyl]-2H-chromen-7-ol

生物活性靶点体外研究体内研究 (2S)-3-(4-hydroxyphenyl)-4-methyl-2-[4-[2-(1-piperidyl)ethoxy]phenyl]-2H-chromen-7-ol 试剂级价格

CAS号:: 252555-01-4

英文名:: (2S)-3-(4-hydroxyphenyl)-4-methyl-2-[4-[2-(1-piperidyl)ethoxy]phenyl]-2H-chromen-7-ol

英文别名:: ACOLBIFENE (hydrochloride);BYQDPIXWTVEVEA-JMAPEOGHSA-N;(2S)-3-(4-hydroxyphenyl)-4-methyl-2-[4-[2-(1-piperidyl)ethoxy]phenyl]-2H-chromen-7-ol;(2S)-3-(4-hydroxyphenyl)-4-methyl-2-[4-(2-piperidin-1-ylethoxy)phenyl]-2H-chromen-7-ol,hydrochloride

中文名:: (2S)-3-(4-hydroxyphenyl)-4-methyl-2-[4-[2-(1-piperidyl)ethoxy]phenyl]-2H-chromen-7-ol

中文别名:: 化合物 T23620

CBNumber:: CB61458796

分子式:: C29H31NO4

分子量:: 0

MOL File:: 252555-01-4.mol

化学性质安全信息用途价格供应商 11

(2S)-3-(4-hydroxyphenyl)-4-methyl-2-[4-[2-(1-piperidyl)ethoxy]phenyl]-2H-chromen-7-ol化学性质

溶解度:: DMSO: 180 mg/mL (364.36 mM)

形态:: Solid

颜色:: White to yellow

安全信息

(2S)-3-(4-hydroxyphenyl)-4-methyl-2-[4-[2-(1-piperidyl)ethoxy]phenyl]-2H-chromen-7-ol性质、用途与生产工艺

生物活性

Acolbifene (EM-652) hydrochloride 是 EM800 的活性代谢物，是具有口服活性的纯抗刺激素和选择性的雌激素受体 (ER) 的拮抗剂，其在 T-47D 细胞中的 IC50 值为 0.110 nM。Acolbifene (EM-652) hydrochloride 具有抗癌活性。

Acolbifene (ACOL) does not affect pathways of cholesterol synthesis, supporting the involvement of the clearance-related receptors in its hypocholesterolemic action.
Acolbifene (EM-652) shows no agonistic activity on ERα and ERβ transcriptional function and blocks the estradiol (E2)-mediated activation of both ERα and ERβ.
Acolbifene (EM-652) shows the most potent inhibition of estradiol-stimulated cell proliferation in human breast cancer cells (ZR-75-1, MCF-7, T-47D) and is devoid of any intrinsic estrogenic activity.

体内研究

Acolbifene (ACOL) reduces food intake and strongly decreases cholesterolemia in rats fed a cholesterol-free diet.
Acolbifene (ACOL) reduces food intake (16%) and weight gain (45%, mainly fat) similarly in both dietary cohorts.

Animal Model:	Female Sprague-Dawley rats (n = 42) initially weighing 175-200 g.
Dosage:	2.5 mg/kg.
Administration:	Oral gavage, once daily for 21 d.
Result:	Prevents tumor growth in rats.

(2S)-3-(4-hydroxyphenyl)-4-methyl-2-[4-[2-(1-piperidyl)ethoxy]phenyl]-2H-chromen-7-ol 上下游产品信息

上游原料

ACOLBIFENE;EM652

下游产品

(2S)-3-(4-hydroxyphenyl)-4-methyl-2-[4-[2-(1-piperidyl)ethoxy]phenyl]-2H-chromen-7-ol 试剂级价格

更新日期	产品编号	产品名称	CAS编号	包装	价格
2024/08/19	HY-16023	(2S)-3-(4-hydroxyphenyl)-4-methyl-2-[4-[2-(1-piperidyl)ethoxy]phenyl]-2H-chromen-7-ol Acolbifene hydrochloride	252555-01-4	5mg	1800元
2024/08/19	HY-16023	(2S)-3-(4-hydroxyphenyl)-4-methyl-2-[4-[2-(1-piperidyl)ethoxy]phenyl]-2H-chromen-7-ol Acolbifene hydrochloride	252555-01-4	10mM * 1mLin DMSO	1956元

(2S)-3-(4-hydroxyphenyl)-4-methyl-2-[4-[2-(1-piperidyl)ethoxy]phenyl]-2H-chromen-7-ol 生产厂家

全球有 11家供应商 (2S)-3-(4-hydroxyphenyl)-4-methyl-2-[4-[2-(1-piperidyl)ethoxy]phenyl]-2H-chromen-7-ol国内生产厂家

供应商	联系电话	电子邮件	国家	产品数	优势度
斯派螺（武汉）药物研发有限公司		eric_feng1954@126.com	中国	9254	55
德州博腾精细化工有限公司		13006575422@163.com	中国	6357	58
济南药研药物化学有限公司		jnyaoyan@163.com	中国	3069	58
南京美韬医药科技有限公司	meitaochem@126.com	meitaochem@126.com	中国	19105	58
TargetMol Chemicals Inc.	+1-781-999-5354 +1-00000000000	marketing@targetmol.com	美国	19892	58
Hubei Jusheng Technology Co.,Ltd.	18871490254	linda@hubeijusheng.com	中国	28180	58
天津普西唐生物医药科技有限公司	010-60605840 15801484223	psaitong@jm-bio.com	中国	29778	58
TargetMol中国（陶术生物）	4008200310	marketing@tsbiochem.com	中国	23963	58
Aladdin Scientific	+1-+1(833)-552-7181	sales@aladdinsci.com	美国	52927	58
杭州摩库生物医药科技有限公司	+86-057181025280; +8617767106207	sales@molcore.com	中国	49739	58

252555-01-4, (2S)-3-(4-hydroxyphenyl)-4-methyl-2-[4-[2-(1-piperidyl)ethoxy]phenyl]-2H-chromen-7-ol 相关搜索:

化合物 T23620
252555-01-4
(2S)-3-(4-hydroxyphenyl)-4-methyl-2-[4-(2-piperidin-1-ylethoxy)phenyl]-2H-chromen-7-ol,hydrochloride
BYQDPIXWTVEVEA-JMAPEOGHSA-N
(2S)-3-(4-hydroxyphenyl)-4-methyl-2-[4-[2-(1-piperidyl)ethoxy]phenyl]-2H-chromen-7-ol
ACOLBIFENE (hydrochloride)