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(2S)-3-(4-hydroxyphenyl)-4-methyl-2-[4-[2-(1-piperidyl)ethoxy]phenyl]-2H-chromen-7-ol

生物活性 靶点 体外研究 体内研究 (2S)-3-(4-hydroxyphenyl)-4-methyl-2-[4-[2-(1-piperidyl)ethoxy]phenyl]-2H-chromen-7-ol 试剂级价格
(2S)-3-(4-hydroxyphenyl)-4-methyl-2-[4-[2-(1-piperidyl)ethoxy]phenyl]-2H-chromen-7-ol, 252555-01-4, 结构式
(2S)-3-(4-hydroxyphenyl)-4-methyl-2-[4-[2-(1-piperidyl)ethoxy]phenyl]-2H-chromen-7-ol
CAS号:
252555-01-4
英文名:
(2S)-3-(4-hydroxyphenyl)-4-methyl-2-[4-[2-(1-piperidyl)ethoxy]phenyl]-2H-chromen-7-ol
英文别名:
ACOLBIFENE (hydrochloride);BYQDPIXWTVEVEA-JMAPEOGHSA-N;(2S)-3-(4-hydroxyphenyl)-4-methyl-2-[4-[2-(1-piperidyl)ethoxy]phenyl]-2H-chromen-7-ol;(2S)-3-(4-hydroxyphenyl)-4-methyl-2-[4-(2-piperidin-1-ylethoxy)phenyl]-2H-chromen-7-ol,hydrochloride
中文名:
(2S)-3-(4-hydroxyphenyl)-4-methyl-2-[4-[2-(1-piperidyl)ethoxy]phenyl]-2H-chromen-7-ol
中文别名:
化合物 T23620;化合物 ACOLBIFENE HYDROCHLORIDE
CBNumber:
CB61458796
分子式:
C29H31NO4
分子量:
0
MOL File:
252555-01-4.mol

(2S)-3-(4-hydroxyphenyl)-4-methyl-2-[4-[2-(1-piperidyl)ethoxy]phenyl]-2H-chromen-7-ol化学性质

溶解度:
DMSO: 180 mg/mL (364.36 mM)
形态:
Solid
颜色:
White to yellow
安全信息

(2S)-3-(4-hydroxyphenyl)-4-methyl-2-[4-[2-(1-piperidyl)ethoxy]phenyl]-2H-chromen-7-ol性质、用途与生产工艺

生物活性

Acolbifene (EM-652) hydrochloride 是 EM800 的活性代谢物，是具有口服活性的纯抗刺激素和选择性的雌激素受体 (ER) 的拮抗剂，其在 T-47D 细胞中的 IC50 值为 0.110 nM。Acolbifene (EM-652) hydrochloride 具有抗癌活性。

靶点

Estrogen receptor

0.110 nM (IC 50 )

体外研究

Acolbifene (ACOL) does not affect pathways of cholesterol synthesis, supporting the involvement of the clearance-related receptors in its hypocholesterolemic action.
Acolbifene (EM-652) shows no agonistic activity on ERα and ERβ transcriptional function and blocks the estradiol (E2)-mediated activation of both ERα and ERβ.
Acolbifene (EM-652) shows the most potent inhibition of estradiol-stimulated cell proliferation in human breast cancer cells (ZR-75-1, MCF-7, T-47D) and is devoid of any intrinsic estrogenic activity.

体内研究

Acolbifene (ACOL) reduces food intake and strongly decreases cholesterolemia in rats fed a cholesterol-free diet.
Acolbifene (ACOL) reduces food intake (16%) and weight gain (45%, mainly fat) similarly in both dietary cohorts.

Animal Model: Female Sprague-Dawley rats (n = 42) initially weighing 175-200 g.
Dosage: 2.5 mg/kg.
Administration: Oral gavage, once daily for 21 d.
Result: Prevents tumor growth in rats.

(2S)-3-(4-hydroxyphenyl)-4-methyl-2-[4-[2-(1-piperidyl)ethoxy]phenyl]-2H-chromen-7-ol 上下游产品信息

上游原料

ACOLBIFENE;EM652

下游产品

(2S)-3-(4-hydroxyphenyl)-4-methyl-2-[4-[2-(1-piperidyl)ethoxy]phenyl]-2H-chromen-7-ol 试剂级价格

更新日期产品编号产品名称CAS编号包装价格
2024/11/08HY-16023(2S)-3-(4-hydroxyphenyl)-4-methyl-2-[4-[2-(1-piperidyl)ethoxy]phenyl]-2H-chromen-7-ol
Acolbifene hydrochloride		252555-01-45mg1800元
2024/11/08HY-16023(2S)-3-(4-hydroxyphenyl)-4-methyl-2-[4-[2-(1-piperidyl)ethoxy]phenyl]-2H-chromen-7-ol
Acolbifene hydrochloride		252555-01-410mM * 1mLin DMSO1956元

(2S)-3-(4-hydroxyphenyl)-4-methyl-2-[4-[2-(1-piperidyl)ethoxy]phenyl]-2H-chromen-7-ol 生产厂家

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斯派螺（武汉）药物研发有限公司 eric_feng1954@126.com 中国 9248 55
德州博腾精细化工有限公司 13006575422@163.com 中国 6355 58
济南药研药物化学有限公司 jnyaoyan@163.com 中国 3069 58
南京美韬医药科技有限公司 meitaochem@126.com meitaochem@126.com 中国 19103 58
TargetMol Chemicals Inc. +1-781-999-5354 +1-00000000000 marketing@targetmol.com 美国 32161 58
Hubei Jusheng Technology Co.,Ltd. 18871490254 linda@hubeijusheng.com 中国 28172 58
天津普西唐生物医药科技有限公司 010-60605840 15801484223 psaitong@jm-bio.com 中国 29774 58
上海一飞生物科技有限公司 021-65675885 18964387627 customer_service@efebio.com 中国 11974 58
TargetMol中国（陶术生物） 15002134094 marketing@targetmol.cn 中国 19703 58
TargetMol Chemicals Inc. +8613564774135 zijue.cai@tsbiochem.com 美国 19884 58
Aladdin Scientific +1-+1(833)-552-7181 sales@aladdinsci.com 美国 52924 58
杭州摩库生物医药科技有限公司 +86-057181025280; +8617767106207 sales@molcore.com 中国 49734 58
 

252555-01-4, (2S)-3-(4-hydroxyphenyl)-4-methyl-2-[4-[2-(1-piperidyl)ethoxy]phenyl]-2H-chromen-7-ol 相关搜索:

  • 抑制剂
  • 化合物 ACOLBIFENE HYDROCHLORIDE
  • 化合物 T23620
  • 252555-01-4
  • (2S)-3-(4-hydroxyphenyl)-4-methyl-2-[4-(2-piperidin-1-ylethoxy)phenyl]-2H-chromen-7-ol,hydrochloride
  • BYQDPIXWTVEVEA-JMAPEOGHSA-N
  • (2S)-3-(4-hydroxyphenyl)-4-methyl-2-[4-[2-(1-piperidyl)ethoxy]phenyl]-2H-chromen-7-ol
  • ACOLBIFENE (hydrochloride)
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