17-碘雄甾-5,16-二烯-3BETA-醇乙酸酯
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- CAS号:
- 114611-53-9
- 英文名:
- 17-Iodoandrosta-5,16-dien-3beta-ol 3-acetate
- 英文别名:
- 17-Iodoandrosta-5,16-dien-3beta-acetate ester;Abiraterone Impurity 51;17-Iodoandrosta-5,16-dien-3β-ol;Abiraterone Acetate InterMediate;Iodoandrosta-5,16-dien-3beta-ol 3-acetate;17-Iodoandrosta-5,16-dien-3β-acetate ester;17-Iodoandrosta-5,16-dien-3β-acetate ester;"17-Iodoandrosta-5,16-dien-3β-ol 3-acetate";17-Iodoandrosta-5,16-dien-3beta-ol 3-acetate;17-lodoandrosta-5,16-dien-3beta-acetate ester
- 中文名:
- 17-碘雄甾-5,16-二烯-3BETA-醇乙酸酯
- 中文别名:
- 阿比特龙杂质51;阿比特龙杂质22;阿比特龙醋酸酯中间体;17-碘雄甾-5,16-二烯-3Β-乙酸酯;17-碘雄甾-5,16-二烯-3Β-醇乙酸酯;17-碘雄甾-5,16-二烯-3BETA-乙酸酯;17-碘雄甾-5,16-二烯-3BETA-醇乙酸酯
- CBNumber:
- CB62547028
- 分子式:
- C21H29IO2
- 分子量:
- 440.36
- MOL File:
- 114611-53-9.mol
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17-碘雄甾-5,16-二烯-3BETA-醇乙酸酯化学性质
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沸点:
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455.8±45.0 °C(Predicted)
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密度:
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1.41
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储存条件:
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2-8°C
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溶解度:
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Chloroform (Slightly), Ethyl Acetate (Slightly)
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形态:
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Solid
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颜色:
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White to Off-White
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17-碘雄甾-5,16-二烯-3BETA-醇乙酸酯性质、用途与生产工艺
17-碘雄甾-5,16-二烯-3BETA-醇乙酸酯为醋酸阿比特龙的制备中间体,2011年FDA批准醋酸阿比特龙口服片剂上市,商品名ZYTIGA。醋酸阿比特龙在体内转化成阿比特龙,阿比特龙是雄性激素合成抑制剂,能够抑制17α-羟化酶/C17,20-裂解酶(CYP17),该酶在睾丸、肾上腺和前列腺瘤组织中表达。临床上通过醋酸阿比特龙与泼尼松联用治疗之前使用过多西他赛化疗患者的转移性去势耐药前列腺癌。
17-碘雄甾-5,16-二烯-3BETA-醇乙酸酯
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17-碘雄甾-5,16-二烯-3BETA-醇乙酸酯
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114611-53-9, 17-碘雄甾-5,16-二烯-3BETA-醇乙酸酯 相关搜索:
- 醋酸阿比特龙中间体
- 阿比特龙中间体
- 中间体
- C21H29IO2
- 阿比特龙杂质51
- 17-碘雄甾-5,16-二烯-3Β-醇乙酸酯
- 17-碘雄甾-5,16-二烯-3Β-乙酸酯
- 阿比特龙杂质22
- 阿比特龙醋酸酯中间体
- 17-碘雄甾-5,16-二烯-3BETA-乙酸酯
- 17-碘雄甾-5,16-二烯-3BETA-醇乙酸酯
- 114611-53-9
- 17-Iodoandrosta-5,16-dien-3β-acetate ester
- (3beta)-17-Iodoandrosta-5,16-dien-3-ol Acetate
- Iodoandrosta-5,16-dien-3beta-ol 3-acetate
- Abiraterone Impurity 51
- 17-Iodoandrosta-5,16-dien-3beta-acetate ester
- "17-Iodoandrosta-5,16-dien-3β-ol 3-acetate"
- 17-Iodoandrosta-5,16-dien-3β-ol
- ABIRATERONE ACETATE INTERMEDIATE /17-IODOANDROSTA-5,16-DIEN-3BETA-OL 3-ACETATE CAS NO: 114611-53-9
- Androsta-5,16-dien-3-ol, 17-iodo-, 3-acetate, (3β)-
- (3S,8R,9S,10R,13S,14S)-17-Iodo-10,13-dimethyl-2,3,4,7,8,9,10,11, 12,13,14,15-dodecahydro-1H-cyclo
- 17-lodoandrosta-5,16-dien-3beta-acetate ester
- (3S,8R,9S,10R,13S,14S)-17-Iodo-10,13-dimethyl-2,3,4,7,8,9,10,11,12,13,14,15-dodecahydro-1H-cyc
- [(3S,8R,9S,10R,13S,14S)-17-iodo-10,13-dimethyl-2,3,4,7,8,9,11,12,14,15-decahydro-1H-cyclopenta[a]phenanthren-3-yl] acetate
- (3S,8R,9S,10R,13S,14S)-17-Iodo-10,13-diMethyl-2,3,4,7,8,9,10,11,12,13,14,15-dodecahydro-1H-cyclopenta[a]phenanthren-3-yl acetate
- (3beta)-17-iodo-Androsta-5,16-dien-3-ol 3-acetate
- 17-Iodoandrosta-5,16-dien-3β-acetate ester
- Abiraterone Acetate InterMediate
- 17-Iodoandrosta-5,16-dien-3beta-ol 3-acetate