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4-氨基-1-(4-C-叠氮基-BETA-D-呋喃阿拉伯糖基)-2(1H)-嘧啶酮
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- CAS号:
- 876708-03-1
- 英文名:
- RO 9187
- 英文别名:
- RO 9187;RO 9187;RO9187;2(1H)-Pyrimidinone, 4-amino-1-(4-C-azido-β-D-arabinofuranosyl)-;4-Amino-1-(4-C -azido-β-D-arabinofuranosyl)-2
(1H )-pyrimidinone;4-Amino-1-(4-C-azido-beta-D-arabinofuranosyl)-2(1H)-pyrimidinone
- 中文名:
- 4-氨基-1-(4-C-叠氮基-BETA-D-呋喃阿拉伯糖基)-2(1H)-嘧啶酮
- 中文别名:
- 化合物 T16774;化合物 RO-9187;4-氨基-1-(4-C-叠氮基-BETA-D-呋喃阿拉伯糖基)-2(1H)-嘧啶酮
- CBNumber:
- CB62628361
- 分子式:
- C9H12N6O5
- 分子量:
- 284.22878
- MOL File:
- 876708-03-1.mol
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4-氨基-1-(4-C-叠氮基-BETA-D-呋喃阿拉伯糖基)-2(1H)-嘧啶酮化学性质
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熔点:
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188.0-189.0℃
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储存条件:
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Store at -20°C
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溶解度:
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H2O : 7.14 mg/mL (25.12 mM; Need ultrasonic)
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形态:
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Powder
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颜色:
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Light yellow to yellow
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4-氨基-1-(4-C-叠氮基-BETA-D-呋喃阿拉伯糖基)-2(1H)-嘧啶酮性质、用途与生产工艺
RO-9187是高效的HCV病毒复制抑制剂，IC50值为171 nM。
RO-9187 is excellent substrates for deoxycytidine kinase and is phosphorylated with efficiencies up to 3-fold higher than deoxycytidine. RO-9187 inhibits RNA synthesis by HCV polymerases from either HCV genotypes 1a and 1b or containing S96T or S282T point mutations with similar potencies, suggesting no cross-resistance with either R1479 (4′-azidocytidine) or 2′-C-methyl nucleosides. The formation of RO-9187-TP increased in a time- and dose-dependent manner. The maximal triphosphate concentration at 24 h is 87 pmol/106 cells with half-maximal triphosphate formation achieved at 12 μM RO-9187.
Plasma exposures of RO-9187 in rats increase in a dose-dependent manner between 10 and 2000 mg/kg after oral dosing. Plasma concentrations of 1.4 and 26 μM (390 and 7454 ng/mL) are achieved in rats and dogs at the 10 mg/kg dose level, respectively. Plasma concentrations up to 57 μM are achieved in rats dosed with 2000 mg/kg/day.
4-氨基-1-(4-C-叠氮基-BETA-D-呋喃阿拉伯糖基)-2(1H)-嘧啶酮
上下游产品信息
上游原料
下游产品
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
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| 2024/11/08 | HY-10870 | 4-氨基-1-(4-C-叠氮基-BETA-D-呋喃阿拉伯糖基)-2(1H)-嘧啶酮
RO-9187 | 876708-03-1 | 5mg | 2000元 |
| 2024/11/08 | HY-10870 | 4-氨基-1-(4-C-叠氮基-BETA-D-呋喃阿拉伯糖基)-2(1H)-嘧啶酮
RO-9187 | 876708-03-1 | 10 mM * 1 mLin DMSO | 2200元 |
4-氨基-1-(4-C-叠氮基-BETA-D-呋喃阿拉伯糖基)-2(1H)-嘧啶酮
生产厂家
876708-03-1, 4-氨基-1-(4-C-叠氮基-BETA-D-呋喃阿拉伯糖基)-2(1H)-嘧啶酮 相关搜索:
- 抑制剂
- 代谢
- 化合物 RO-9187
- 化合物 T16774
- 4-氨基-1-(4-C-叠氮基-BETA-D-呋喃阿拉伯糖基)-2(1H)-嘧啶酮
- 876708-03-1
- 2(1H)-Pyrimidinone, 4-amino-1-(4-C-azido-β-D-arabinofuranosyl)-
- 4-Amino-1-(4-C -azido-β-D-arabinofuranosyl)-2
(1H )-pyrimidinone
- RO 9187;RO9187
- 4-Amino-1-(4-C-azido-beta-D-arabinofuranosyl)-2(1H)-pyrimidinone
- RO 9187