GSK1324726A (I-BET726)
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- CAS号:
- 1300031-52-0
- 英文名:
- GSK1324726A (I-BET726)
- 英文别名:
- GSK1324726A;CS-1736;I-BET726;I-BET726; I-BET 726;GSK1324726A (I-BET726);I-BET726 (GSK1324726A);GSK1324726A (I-BET726) USP/EP/BP;GSK-1324726A,Apoptosis,GSK1324726A,Inhibitor,Epigenetic Reader Domain,inhibit;4-(cis-1-Acetyl-4-((4-chlorophenyl)amino)-2-methyl-1,2,3,4-tetrahydroquinolin-6-yl)benzoic acid;4-((2S,4R)-1-acetyl-4-(4-chlorophenylamino)-2-methyl-1,2,3,4-tetrahydroquinolin-6-yl)benzoic acid
- 中文名:
- GSK1324726A (I-BET726)
- 中文别名:
- 化合物GSK1324726A;BET蛋白抑制剂(GSK1324726A);4-((2S,4R)-1-乙酰基-4-((4-氯苯基)氨基)-2-甲基-1,2,3,4-四氢喹啉-6-基)苯甲酸;4-[(2S,4R)-1-乙酰基-4-[(4-氯苯基)氨基]-2-甲基-1,2,3,4-四氢-6-喹啉基]苯甲酸
- CBNumber:
- CB62677051
- 分子式:
- C25H23ClN2O3
- 分子量:
- 434.91
- MOL File:
- 1300031-52-0.mol
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GSK1324726A (I-BET726)化学性质
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沸点:
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707.3±60.0 °C(Predicted)
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密度:
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1.304±0.06 g/cm3(Predicted)
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储存条件:
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Store at -20°C
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溶解度:
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insoluble in H2O; ≥1.87 mg/mL in EtOH with gentle warming and ultrasonic; ≥17.7 mg/mL in DMSO
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形态:
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Powder
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酸度系数(pKa):
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4.20±0.10(Predicted)
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颜色:
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White to light yellow
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InChIKey:
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FAWSUKOIROHXAP-NPMXOYFQSA-N
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SMILES:
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C(O)(=O)C1=CC=C(C2C=CC3=C(C=2)[C@H](NC2=CC=C(Cl)C=C2)C[C@H](C)N3C(C)=O)C=C1
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GSK1324726A (I-BET726)性质、用途与生产工艺
GSK1324726A（I-BET726）是BET家族蛋白的高选择性抑制剂，对BRD2, BRD3, 和BRD4的IC50分别为41 nM, 31 nM,和22 nM。
In neuroblastoma cell lines, GSK1324726A inhibits cell growth and induces cytotoxicity. GSK1324726A also modulates expression of genes involved in apoptosis, signaling, and MYC-family pathways, including the direct suppression of BCL2 and MYCN.
In the mouse SK–N-AS and CHP-212 models, GSK1324726A (15 mg/kg p.o.) results in tumor growth inhibition and down-regulation MYCN and BCL2 expression. In a mouse septic shock model, GSK1324726A (10 mg/kg i.v.) shows potent anti-inflammatory effects, and prevents death of diseased animals.
GSK1324726A (I-BET726)
上下游产品信息
上游原料
下游产品
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
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| 2024/04/30 | HY-13960 | GSK1324726A (I-BET726)
GSK1324726A | 1300031-52-0 | 5mg | 900元 |
| 2024/04/30 | HY-13960 | GSK1324726A (I-BET726)
GSK1324726A | 1300031-52-0 | 10mM * 1mLin DMSO | 990元 |
GSK1324726A (I-BET726)
生产厂家
1300031-52-0, GSK1324726A (I-BET726) 相关搜索:
- Inhibitors
- 药靶配体
- 细胞生物学试剂
- 小分子抑制剂，天然产物
- 抑制剂
- 化合物GSK1324726A
- 4-((2S,4R)-1-乙酰基-4-((4-氯苯基)氨基)-2-甲基-1,2,3,4-四氢喹啉-6-基)苯甲酸
- BET蛋白抑制剂(GSK1324726A)
- 4-[(2S,4R)-1-乙酰基-4-[(4-氯苯基)氨基]-2-甲基-1,2,3,4-四氢-6-喹啉基]苯甲酸
- 1300031-52-0
- I-BET726 (GSK1324726A)
- GSK-1324726A,Apoptosis,GSK1324726A,Inhibitor,Epigenetic Reader Domain,inhibit
- GSK1324726A
- GSK1324726A (I-BET726) USP/EP/BP
- Benzoic acid, 4-[(2S,4R)-1-acetyl-4-[(4-chlorophenyl)amino]-1,2,3,4-tetrahydro-2-methyl-6-quinolinyl]-
- I-BET726
- 4-[(2S,4R)-1-Acetyl-4-[(4-chlorophenyl)amino]-1,2,3,4-tetrahydro-2-methyl-6-quinolinyl]benzoic acid
- CS-1736
- I-BET726; I-BET 726
- 4-(cis-1-Acetyl-4-((4-chlorophenyl)amino)-2-methyl-1,2,3,4-tetrahydroquinolin-6-yl)benzoic acid
- GSK1324726A (I-BET726)
- 4-[(2S,4R)-1-Acetyl-4-[(4-chlorophenyl)amino]-2-methyl-1,2,3,4-tetrahydro-6-quinolinyl]benzoic acid
- 4-((2S,4R)-1-acetyl-4-(4-chlorophenylamino)-2-methyl-1,2,3,4-tetrahydroquinolin-6-yl)benzoic acid