Y320
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- CAS号:
- 288250-47-5
- 英文名:
- Y320
- 英文别名:
- Y320;Y320; Y 320;Y-320, >=98%;1-(4-Chlorophenyl)-N-(3-cyano-4-(4-morpholinopiperidin-1-yl)phenyl)-5-methyl-1H-pyrazole-4-car;1-(4-Chlorophenyl)-N-(3-cyano-4-(4-morpholinopiperidin-1-yl)phenyl)-5-methyl-1H-pyrazole-4-carboxami;1-(4-CHLOROPHENYL)-N-(3-CYANO-4-(4-MORPHOLINOPIPERIDIN-1-YL)PHENYL)-5-METHYL-1H-PYRAZOLE-4-CARBOXAMIDE;1-(4-chlorophenyl)-N-{3-cyano-4-[4-(morpholin-4-yl)piperidin-1-yl]phenyl}-5-methylpyrazole-4-carboxamide;1-(4-Chlorophenyl)-N-[3-cyano-4-[4-(4-morpholinyl)-1-piperidinyl]phenyl]-5-methyl-1H-pyrazole-4-carboxamide;1H-Pyrazole-4-carboxamide, 1-(4-chlorophenyl)-N-[3-cyano-4-[4-(4-morpholinyl)-1-piperidinyl]phenyl]-5-methyl-;1-(4-Chlorophenyl)-N-[3-cyano-4-[4-(4-morpholinyl)-1-piperidinyl]phenyl]-5-methyl-1H-pyrazole-4-carboxamide Y320
- 中文名:
- Y320
- 中文别名:
- 化合物Y320;1-(4-氯苯基)-N-(3-氰基-4-(4-吗啉哌啶-1-基)苯基)-5-甲基-1H-吡唑-4-甲酰胺;1-(4-氯苯基)-N-[3-氰基-4-[4-(4-吗啉基)-1-哌啶基]苯基]-5-甲基-1H-吡唑-4-甲酰胺
- CBNumber:
- CB62685328
- 分子式:
- C27H29ClN6O2
- 分子量:
- 505.01
- MOL File:
- 288250-47-5.mol
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Y320化学性质
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沸点:
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631.2±55.0 °C(Predicted)
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密度:
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1.34±0.1 g/cm3(Predicted)
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储存条件:
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2-8°C
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溶解度:
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≥24.8 mg/mL in DMSO with gentle warming; insoluble in H2O; insoluble in EtOH
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形态:
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solid
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酸度系数(pKa):
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11.82±0.70(Predicted)
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颜色:
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Off-white to pink
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Y320性质、用途与生产工艺
Y-320 是一种口服有效的 immunomodulator, 它通过 CD4 T 细胞刺激 IL-15 从而抑制IL-17的产生,其IC50为20到60 nM。
Y-320通过被IL-15, CXCL12, 和anti-CD3 mAb刺激的小鼠CD4 T细胞也会抑制IFN-γ和TNF-α的产生。
Y-320 (0.3-3毫克/千克,口服)改善小鼠体内胶原诱导性关节炎(CIA),减少关节炎性关节中的IL-17 mRNA,并且在猕猴体内表现出对CIA的治疗作用。此外,Y-320与抗-TNF-α mAb结合在小鼠体内表现出对慢性CIA的协同作用。
Y-320 是一种口服有效的 immunomodulator, 它通过 CD4 T 细胞刺激 IL-15 从而抑制IL-17的产生,其IC50为20到60 nM。
Y-320通过被IL-15, CXCL12, 和anti-CD3 mAb刺激的小鼠CD4 T细胞也会抑制IFN-γ和TNF-α的产生。
Y-320 (0.3-3毫克/千克,口服)改善小鼠体内胶原诱导性关节炎(CIA),减少关节炎性关节中的IL-17 mRNA,并且在猕猴体内表现出对CIA的治疗作用。此外,Y-320与抗-TNF-α mAb结合在小鼠体内表现出对慢性CIA的协同作用。
Y320
上下游产品信息
上游原料
下游产品
更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
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2024/08/19 | HY-15898 | Y-320 | | 1 mg | 477元 |
2024/08/19 | HY-15898 | Y320 Y-320 | 288250-47-5 | 5mg | 1050元 |
288250-47-5, Y320 相关搜索:
- Inhibitors
- 药靶配体
- 小分子抑制剂
- 小分子抑制剂,天然产物
- C27H29ClN6O2
- 化合物Y320
- 1-(4-氯苯基)-N-(3-氰基-4-(4-吗啉哌啶-1-基)苯基)-5-甲基-1H-吡唑-4-甲酰胺
- 1-(4-氯苯基)-N-[3-氰基-4-[4-(4-吗啉基)-1-哌啶基]苯基]-5-甲基-1H-吡唑-4-甲酰胺
- 288250-47-5
- 1-(4-chlorophenyl)-N-{3-cyano-4-[4-(morpholin-4-yl)piperidin-1-yl]phenyl}-5-methylpyrazole-4-carboxamide
- 1H-Pyrazole-4-carboxamide, 1-(4-chlorophenyl)-N-[3-cyano-4-[4-(4-morpholinyl)-1-piperidinyl]phenyl]-5-methyl-
- Y320; Y 320
- 1-(4-Chlorophenyl)-N-(3-cyano-4-(4-morpholinopiperidin-1-yl)phenyl)-5-methyl-1H-pyrazole-4-carboxami
- Y-320, >=98%
- Y320 1-(4-Chlorophenyl)-N-[3-cyano-4-[4-(4-morpholinyl)-1-piperidinyl]phenyl]-5-methyl-1H-pyrazole-4-carboxamide
- 1-(4-Chlorophenyl)-N-[3-cyano-4-[4-(4-morpholinyl)-1-piperidinyl]phenyl]-5-methyl-1H-pyrazole-4-carboxamide Y320
- 1-(4-Chlorophenyl)-N-(3-cyano-4-(4-morpholinopiperidin-1-yl)phenyl)-5-methyl-1H-pyrazole-4-car
- 1-(4-Chlorophenyl)-N-[3-cyano-4-[4-(4-morpholinyl)-1-piperidinyl]phenyl]-5-methyl-1H-pyrazole-4-carboxamide
- 1-(4-CHLOROPHENYL)-N-(3-CYANO-4-(4-MORPHOLINOPIPERIDIN-1-YL)PHENYL)-5-METHYL-1H-PYRAZOLE-4-CARBOXAMIDE
- Y320