CP 532623

生物活性靶点体外研究体内研究 CP 532623 试剂级价格

CP 532623

CAS号:: 261947-38-0

英文名:: (2R,4S)-4-[Acetyl[[3,5-bis(trifluoromethyl)phenyl]methyl]amino]-2-ethyl-3,4-dihydro-6-(trifluoromethyl)-1(2H)-quinolinecarboxylic acid 1-methylethyl ester

英文别名:: CP 532623;CP532623,CP 532623;CP 532623 >=98% (HPLC);(2R,4S)-4-[Acetyl[[3,5-bis(trifluoromethyl)phenyl]methyl]amino]-2-ethyl-3,4-dihydro-6-(trifluoromethyl)-1(2H)-quinolinecarboxylic acid 1-methylethyl ester;1(2H)-Quinolinecarboxylic acid, 4-[acetyl[[3,5-bis(trifluoromethyl)phenyl]methyl]amino]-2-ethyl-3,4-dihydro-6-(trifluoromethyl)-, 1-methylethyl ester, (2R,4S)-

中文名:: CP 532623

中文别名:: 化合物 T15004

CBNumber:: CB62750378

分子式:: C27H27F9N2O3

分子量:: 598.5

MOL File:: 261947-38-0.mol

化学性质安全信息用途价格供应商 11

CP 532623化学性质

熔点:: 101.8 °C

沸点:: 523.8±50.0 °C(Predicted)

密度:: 1.38±0.1 g/cm3(Predicted)

储存条件:: 2-8°C

溶解度:: DMSO: soluble20mg/mL, clear

形态:: powder

酸度系数(pKa):: -0.93±0.40(Predicted)

颜色:: white to beige

安全信息

WGK Germany:	3

CP 532623性质、用途与生产工艺

生物活性

CP-532623 是 CETP 抑制剂，可提高高密度脂蛋白胆固醇水平。CP-532623 与 Torcetrapib 的结构相似，并具有高度亲脂性。

CP-532623 is highly lymphatically transported (28% of dose), and lymphatic transport is closely correlated with drug affinity for ex-vivo lymph lipoproteins or triglyceride emulsions and poorly relates to solubility in mixtures of lipoprotein core and/or surface lipids. CP-532623 alters the kinetics of lymph lipid transport and decreases lymph lipid transport in chylomicrons.

体内研究

CP-532623 (50 mg; oral administration; adult male greyhound dogs) treatment substantially transports into the lymphatic system (>25% dose) in fed and fasted dogs. Food enhances oral bioavailability (from 44 to 58%, respectively) and the proportion of the absorbed dose transports via the lymph (from 61 to 86% and from 68 to 83%, respectively). Lymphatic triglyceride transport is significantly lower in fed dogs administered CP-532623.

Animal Model:	Adult male greyhound dogs (27-39 kg)
Dosage:	50 mg
Administration:	Oral administration with a long-chain lipid formulation to fed lymphcannulated
Result:	Substantially transported into the lymphatic system (>25% dose) in fed and fasted dogs. Food enhanced oral bioavailability and the proportion of the absorbed dose transported via the lymph.

CP 532623 上下游产品信息

上游原料

下游产品

CP 532623 试剂级价格

更新日期	产品编号	产品名称	CAS编号	包装	价格
2024/04/30	HY-123039	CP 532623 CP-532623	261947-38-0	5mg	2160元
2024/01/25	HY-123039	CP-532623		1 mg	2090元

CP 532623 生产厂家

全球有 11家供应商 CP 532623国内生产厂家

供应商	联系电话	电子邮件	国家	产品数	优势度
广州爱纯医药科技有限公司	020-39119399 18927568969	isunpharm@qq.com	中国	4428	55
Sigma-Aldrich西格玛奥德里奇(上海)贸易有限公司	021-61415566 800-8193336	orderCN@merckgroup.com	中国	51471	80
TargetMol Chemicals Inc.	+1-781-999-5354 +1-00000000000	marketing@targetmol.com	美国	19892	58
上海源溪生物科技有限公司	021-58447131 13564518121	sales@dcchemicals.com	中国	9412	58
安耐吉化学&3A（安徽泽升科技有限公司）	021-58432009 400-005-6266	marketing1@energy-chemical.com	中国	44843	58
天津普西唐生物医药科技有限公司	010-60605840 15801484223	psaitong@jm-bio.com	中国	29778	58
TargetMol中国（陶术生物）	4008200310	marketing@tsbiochem.com	中国	24017	58
銳迪國際科技有限公司	18024082417	market@ubiochem.com	中国	9282	58

261947-38-0, CP 532623 相关搜索:

C27H27F9N2O3
化合物 T15004
261947-38-0
CP532623,CP 532623
CP 532623 >=98% (HPLC)
1(2H)-Quinolinecarboxylic acid, 4-[acetyl[[3,5-bis(trifluoromethyl)phenyl]methyl]amino]-2-ethyl-3,4-dihydro-6-(trifluoromethyl)-, 1-methylethyl ester, (2R,4S)-
CP 532623
(2R,4S)-4-[Acetyl[[3,5-bis(trifluoromethyl)phenyl]methyl]amino]-2-ethyl-3,4-dihydro-6-(trifluoromethyl)-1(2H)-quinolinecarboxylic acid 1-methylethyl ester